Patents by Inventor Wei-hsien Liu
Wei-hsien Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240091283Abstract: The present disclosure provides the use of Lactobacillus paracasei ET-22 in enhancing resistance of the intestinal tract to bacterial infection and improving intestinal immunity. Particularly, the present disclosure provides the use of a Lactobacillus paracasei in the preparation of a composition for improving intestinal immunity, wherein the Lactobacillus paracasei has a deposit number of CGMCC 15077. The present inventors have discovered that this bacteria strain alone can significantly improve the resistance of the intestinal tract to bacterial infection, combat invasion by pathogenic bacteria in the intestinal system, maintain the intestinal barrier function, and/or prevent diarrhea caused by pathogenic bacteria.Type: ApplicationFiled: May 28, 2021Publication date: March 21, 2024Inventors: Wei-Hsien Liu, Gisela Adrienne Weiss, Carolien Annika Van Loo-Bouwman, Gerrit Smit, Wen Zhao, Wei-Lian Hung
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Publication number: 20240072021Abstract: A package structure and the manufacturing method thereof are provided. The package structure includes a first package including at least one first semiconductor die encapsulated in an insulating encapsulation and through insulator vias electrically connected to the at least one first semiconductor die, a second package including at least one second semiconductor die and conductive pads electrically connected to the at least one second semiconductor die, and solder joints located between the first package and the second package. The through insulator vias are encapsulated in the insulating encapsulation. The first package and the second package are electrically connected through the solder joints. A maximum size of the solder joints is greater than a maximum size of the through insulator vias measuring along a horizontal direction, and is greater than or substantially equal to a maximum size of the conductive pads measuring along the horizontal direction.Type: ApplicationFiled: October 26, 2023Publication date: February 29, 2024Applicant: Taiwan Semiconductor Manufacturing Company, Ltd.Inventors: Wei-Yu Chen, An-Jhih Su, Chi-Hsi Wu, Der-Chyang Yeh, Li-Hsien Huang, Po-Hao Tsai, Ming-Shih Yeh, Ta-Wei Liu
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Patent number: 11911422Abstract: A Bifidobacterium lactis BL-99 strain capable of enhancing immunity and the use thereof, which belongs to the technical field of microorganisms, is described. The Bifidobacterium lactis BL-99 provided by the present invention is deposited in China General Microbiological Culture Collection Center CGMCC on Apr. 26, 2018 with the deposit number CGMCC No. 15650. The bacteria have gastric acid resistance and intestinal fluid resistance, can significantly promote the growth of Bifidobacterium and Lactobacillus, significantly increase antibody-producing cells and half hemolysis value HC50, activate NK cell activity, and can be used to prepare foods for immunity enhancement. It also has the effects in preventing osteoporosis, increasing blood calcium and/or phosphorus ions, which has a wide range of application prospects.Type: GrantFiled: March 3, 2022Date of Patent: February 27, 2024Assignee: Inner Mongolia Yili Industrial Group Co., Ltd.Inventors: Wei-Hsien Liu, Wei-Lian Hung, Ting Sun, Wen Zhao, Ignatius Man-Yau Szeto
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Patent number: 11911423Abstract: A Bifidobacterium lactis BL-99 strain capable of enhancing immunity and the use thereof, which belongs to the technical field of microorganisms, is described. The Bifidobacterium lactis BL-99 provided by the present invention is deposited in China General Microbiological Culture Collection Center CGMCC on Apr. 26, 2018 with the deposit number CGMCC No. 15650. The bacteria have gastric acid resistance and intestinal fluid resistance, can significantly promote the growth of Bifidobacterium and Lactobacillus, significantly increase antibody-producing cells and half hemolysis value HC50, activate NK cell activity, and can be used to prepare foods for immunity enhancement. It also has the effects in preventing osteoporosis, increasing blood calcium and/or phosphorus ions, which has a wide range of application prospects.Type: GrantFiled: March 3, 2022Date of Patent: February 27, 2024Assignee: Inner Mongolia Yili Industrial Group Co., Ltd.Inventors: Wei-Hsien Liu, Wei-Lian Hung, Ting Sun, Wen Zhao, Ignatius Man-Yau Szeto
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Publication number: 20230414680Abstract: The present disclosure provides novel uses of Bifidobacterium lactis BL-99 in anti-aging and improving innate immunity. The Bifidobacterium lactis strain according to the present disclosure has a deposit number of CGMCC 15650. It is discovered in the present disclosure that this strain alone has an anti-aging effect, is capable of improving innate immunity of an organism, and is capable of enhancing resistance of an organism to Staphylococcus aureus infection, thereby providing use of the Bifidobacterium lactis strain of deposit number CGMCC 15650 in preparation of a composition having an anti-aging effect, capable of improving innate immunity of an organism, and/or capable of enhancing resistance of an organism to Staphylococcus aureus infection.Type: ApplicationFiled: July 13, 2021Publication date: December 28, 2023Inventors: Wei-Hsien Liu, Wen Zhao, Wei-Lian Hung, Gisela Adrienne Weiss, Carolien Annika Van Loo-Bouwman
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Patent number: 11666613Abstract: A new use of Lactobacillus paracasei subsp. paracasei K56 capable of regulating the gastrointestinal flora balance is described. The deposit number of the Lactobacillus paracasei subsp. paracasei is DSM27447. This strain alone has the ability to significantly promote the growth of intestinal Bifidobacterium and Lactobacillus, suppress Desulfovibrio and/or Enterobacteria in the intestine, suppress Helicobacter and/or Escherichia-Shigella, and can endure a simulated in vitro gastrointestinal fluid stress environment. Experiments in mice show that this strain has no acute oral toxicity, no antibiotic resistance, and may be safely used in food processing.Type: GrantFiled: December 28, 2020Date of Patent: June 6, 2023Assignee: Inner Mongolia Yili Industrial Group Co., Ltd.Inventors: Wei-Hsien Liu, Wei-Lian Hung, Ting Sun, Wen Zhao, Ignatius Man-Yau Szeto
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Publication number: 20230000932Abstract: The present invention provides novel use of Lactobacillus paracasei subsp. paracasei K56 in alleviation of intestinal inflammation. Lactobacillus paracasei subsp. paracasei K56 of the present invention has the deposit number CGMCC 15139 or DSM 27447. It was discovered in the present invention that the strain alone was highly efficacious at alleviating intestinal inflammation, reducing inflammatory factors IL-6 and/or TNF-?, promoting the anti-inflammatory factor IL-10, and reducing the tissue damage of colitis.Type: ApplicationFiled: November 19, 2020Publication date: January 5, 2023Inventors: Wei-Hsien Liu, Wen Zhao, Ting Sun, Wei-Lian Hung, Chao Wu, Guowen Ma, Haibin Zhang
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Publication number: 20220401499Abstract: The present invention provides novel use of Bifidobacterium lactis BL-99 in suppression of intestinal inflammation. Bifidobacterium lactis BL-99 of the present invention has the deposit number CGMCC 15650. It was discovered in the present invention that the strain alone was highly efficacious at suppressing intestinal inflammation, reducing inflammatory factors IL-6 and/or TNF-?, promoting anti-inflammatory factor IL-10, and reducing the tissue damage of colitis.Type: ApplicationFiled: November 19, 2020Publication date: December 22, 2022Inventors: Wei-Lian Hung, Wen Zhao, Wei-Hsien Liu, Haibin Zhang, Xiaojing Yin
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Publication number: 20220313755Abstract: A Bifidobacterium lactis BL-99 strain capable of enhancing immunity and the use thereof, which belongs to the technical field of microorganisms, is described. The Bifidobacterium lactis BL-99 provided by the present invention is deposited in China General Microbiological Culture Collection Center CGMCC on Apr. 26, 2018 with the deposit number CGMCC No. 15650. The bacteria have gastric acid resistance and intestinal fluid resistance, can significantly promote the growth of Bifidobacterium and Lactobacillus, significantly increase antibody-producing cells and half hemolysis value HC50, activate NK cell activity, and can be used to prepare foods for immunity enhancement. It also has the effects in preventing osteoporosis, increasing blood calcium and/or phosphorus ions, which has a wide range of application prospects.Type: ApplicationFiled: March 3, 2022Publication date: October 6, 2022Inventors: Wei-Hsien Liu, Wei-Lian Hung, Ting Sun, Wen Zhao, Ignatius Man-Yau Szeto
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Publication number: 20220313754Abstract: A Bifidobacterium lactis BL-99 strain capable of enhancing immunity and the use thereof, which belongs to the technical field of microorganisms, is described. The Bifidobacterium lactis BL-99 provided by the present invention is deposited in China General Microbiological Culture Collection Center CGMCC on Apr. 26, 2018 with the deposit number CGMCC No. 15650. The bacteria have gastric acid resistance and intestinal fluid resistance, can significantly promote the growth of Bifidobacterium and Lactobacillus, significantly increase antibody-producing cells and half hemolysis value HC50, activate NK cell activity, and can be used to prepare foods for immunity enhancement. It also has the effects in preventing osteoporosis, increasing blood calcium and/or phosphorus ions, which has a wide range of application prospects.Type: ApplicationFiled: March 3, 2022Publication date: October 6, 2022Inventors: Wei-Hsien Liu, Wei-Lian Hung, Ting Sun, Wen Zhao, Ignatius Man-Yau Szeto
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Patent number: 11298382Abstract: A Bifidobacterium lactis BL-99 strain capable of enhancing immunity and the use thereof, which belongs to the technical field of microorganisms, is described. The Bifidobacterium lactis BL-99 provided by the present invention is deposited in China General Microbiological Culture Collection Center CGMCC on Apr. 26, 2018 with the deposit number CGMCC No. 15650. The bacteria have gastric acid resistance and intestinal fluid resistance, can significantly promote the growth of Bifidobacterium and Lactobacillus, significantly increase antibody-producing cells and half hemolysis value HC50, activate NK cell activity, and can be used to prepare foods for immunity enhancement. It also has the effects in preventing osteoporosis, increasing blood calcium and/or phosphorus ions, which has a wide range of application prospects.Type: GrantFiled: March 30, 2021Date of Patent: April 12, 2022Assignee: Inner Mongolia Yili Industrial Group Co., Ltd.Inventors: Wei-Hsien Liu, Wen Zhao, Wei-Lian Hung, Ting Sun, Ignatius Man-Yau Szeto, Haotian Feng, Philip Andrew Wescombe, Haoqiu Li
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Patent number: 11274275Abstract: The present application relates to a Lactobacillus paracasei ET-22 strain and use thereof. The present application provides a Lactobacillus paracasei ET-22 strain with a deposit number of CGMCC No. 15077, a composition containing the strain and a method of treating a subject using the strain. The present application also relates to a method for treating a subject, including administering an effective amount of the Lactobacillus paracasei ET-22 strain to a subject in need thereof for 1) whitening teeth and/or inhibiting oral pathogens; 2) adjusting balance of flora in the subject; 3) promoting growth of bifidobacteria and/or lactic acid bacteria; and/or 4) enhancing immunity of the subject.Type: GrantFiled: September 23, 2019Date of Patent: March 15, 2022Assignee: Inner Mongolia Yili Industrial Group Co., Ltd.Inventors: Wei-Hsien Liu, Wei-Lian Hung, Ting Sun, Ignatius Man-Yau Szeto, Wen Zhao
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Publication number: 20210253995Abstract: The present application relates to a Lactobacillus paracasei ET-22 strain and use thereof. The present application provides a Lactobacillus paracasei ET-22 strain with a deposit number of CGMCC No. 15077, a composition containing the strain and a method of treating a subject using the strain. The present application also relates to a method for treating a subject, including administering an effective amount of the Lactobacillus paracasei ET-22 strain to a subject in need thereof for 1) whitening teeth and/or inhibiting oral pathogens; 2) adjusting balance of flora in the subject; 3) promoting growth of bifidobacteria and/or lactic acid bacteria; and/or 4) enhancing immunity of the subject.Type: ApplicationFiled: September 23, 2019Publication date: August 19, 2021Inventors: Wei-Hsien LIU, Wei-Lian HUNG, Ting SUN, Ignatius Man-Yau SZETO, Wen ZHAO
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Publication number: 20210228656Abstract: A Bifidobacterium lactis BL-99 strain capable of enhancing immunity and the use thereof, which belongs to the technical field of microorganisms, is described. The Bifidobacterium lactis BL-99 provided by the present invention is deposited in China General Microbiological Culture Collection Center CGMCC on Apr. 26, 2018 with the deposit number CGMCC No. 15650. The bacteria have gastric acid resistance and intestinal fluid resistance, can significantly promote the growth of Bifidobacterium and Lactobacillus, significantly increase antibody-producing cells and half hemolysis value HC50, activate NK cell activity, and can be used to prepare foods for immunity enhancement. It also has the effects in preventing osteoporosis, increasing blood calcium and/or phosphorus ions, which has a wide range of application prospects.Type: ApplicationFiled: March 30, 2021Publication date: July 29, 2021Inventors: Wei-Hsien Liu, Wen Zhao, Wei-Lian Hung, Ting Sun, Ignatius Man-Yau Szeto, Haotian Feng, Philip Andrew Wescombe, Haoqiu Li
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Publication number: 20210113632Abstract: A new use of Lactobacillus paracasei subsp. paracasei K56 capable of regulating the gastrointestinal flora balance is described. The deposit number of the Lactobacillus paracasei subsp. paracasei is DSM27447. This strain alone has the ability to significantly promote the growth of intestinal Bifidobacterium and Lactobacillus, suppress Desulfovibrio and/or Enterobacteria in the intestine, suppress Helicobacter and/or Escherichia-Shigella, and can endure a simulated in vitro gastrointestinal fluid stress environment. Experiments in mice show that this strain has no acute oral toxicity, no antibiotic resistance, and may be safely used in food processing.Type: ApplicationFiled: December 28, 2020Publication date: April 22, 2021Inventors: Wei-Hsien Liu, Wei-Lian Hung, Ting Sun, Wen Zhao, Ignatius Man-Yau Szeto
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Patent number: 10967013Abstract: The present invention provides an isolated lactic acid bacterium, Lactobacillus plantarum subsp. plantarum PS128 deposited under DSMZ Accession No. DSM 28632, for prophylaxis or treatment of a stress-induced disorder. The present invention further provides a composition for prophylaxis or treatment of a stress-induced disorder that comprises Lactobacillus plantarum subsp. plantarum PS128. Moreover, the present invention provides a method for prophylaxis or treatment of a stress-induced disorder in a subject that comprises a step of administering an effective amount of Lactobacillus plantarum subsp. plantarum PS128 to the subject.Type: GrantFiled: April 23, 2014Date of Patent: April 6, 2021Assignee: National Yang-Ming UniversityInventors: Ying-Chieh Tsai, Wei-Hsien Liu, Yi-Chen Juan, Chien-Chen Wu
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Publication number: 20150306157Abstract: The present invention provides an isolated lactic acid bacterium, Lactobacillus plantarum subsp. plantarum PS128 deposited under DSMZ Accession No. DSM 28632, for prophylaxis or treatment of a stress-induced disorder. The present invention further provides a composition for prophylaxis or treatment of a stress-induced disorder that comprises Lactobacillus plantarum subsp. plantarum PS128. Moreover, the present invention provides a method for prophylaxis or treatment of a stress-induced disorder in a subject that comprises a step of administering an effective amount of Lactobacillus plantarum subsp. plantarum PS128 to the subject.Type: ApplicationFiled: April 23, 2014Publication date: October 29, 2015Applicant: NATIONAL YANG-MING UNIVERSITYInventors: Ying-Chieh Tsai, Wei-Hsien Liu, Yi-Chen Juan, Chien-Chen Wu
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Patent number: 7945703Abstract: A matrix architecture for KVM extenders connecting a plurality of console terminals and a plurality of computers. The matrix architecture for KVM extenders includes a plurality of first extenders and a plurality of second extenders. The first extenders transform keyboard, mouse analog signals into keyboard, mouse data packets and transform video data packets into video signals for console terminals. The second extenders transform video signals into video data packets and transform keyboard, mouse data packets into keyboard, mouse analog signals. The broadcasters broadcast keyboard, video, mouse data packets, each having a source address and a target address to couple computers to console terminals by broadcasting video data packets from second extenders to first extenders and to couple console terminals to computers by broadcasting keyboard, mouse data packets from first extenders to second extenders.Type: GrantFiled: May 21, 2010Date of Patent: May 17, 2011Assignee: Aten International Co., Ltd.Inventors: Kheng-chuan Sim, Wei-hsien Liu, Chih-tao Hsieh
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Publication number: 20100228884Abstract: A matrix architecture for KVM extenders connecting a plurality of console terminals and a plurality of computers. The matrix architecture for KVM extenders includes a plurality of first extenders and a plurality of second extenders. The first extenders transform keyboard, mouse analog signals into keyboard, mouse data packets and transform video data packets into video signals for console terminals. The second extenders transform video signals into video data packets and transform keyboard, mouse data packets into keyboard, mouse analog signals. The broadcasters broadcast keyboard, video, mouse data packets, each having a source address and a target address to couple computers to console terminals by broadcasting video data packets from second extenders to first extenders and to couple console terminals to computers by broadcasting keyboard, mouse data packets from first extenders to second extenders.Type: ApplicationFiled: May 21, 2010Publication date: September 9, 2010Applicant: ATEN INTERNATIONAL CO., LTD.Inventors: Kheng-chuan Sim, Wei-hsien Liu, Chih-tao Hsieh
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Patent number: 7752339Abstract: A matrix architecture for KVM extenders connecting a plurality of console terminals and a plurality of computers. The matrix architecture for KVM extenders includes a plurality of first extenders and a plurality of second extenders. The first extenders transform keyboard, mouse analog signals into keyboard, mouse data packets and transform video data packets into video signals for console terminals. The second extenders transform video signals into video data packets and transform keyboard, mouse data packets into keyboard, mouse analog signals. The broadcasters broadcast keyboard, video, mouse data packets, each having a source address and a target address to couple computers to console terminals by broadcasting video data packets from second extenders to first extenders and to couple console terminals to computers by broadcasting keyboard, mouse data packets from first extenders to second extenders.Type: GrantFiled: October 11, 2005Date of Patent: July 6, 2010Assignee: Aten International Co., Ltd.Inventors: Kheng-chuan Sim, Wei-hsien Liu, Chih-tao Hsieh