Abstract: The present invention relates to multi-ribozymes and their use to target RNA in a tissue-specific, target RNA-specific, or pathogen-specific manner for the treatment of cancers, proliferative disease, and bacterial, parasitic and viral infections. More specifically, the present invention relates to the use of virions and viral vectors to package and deliver DNA encoding the multi-ribozymes to a host. The present invention relates to the use of liposomes and lipid-DNA complexes to deliver DNA encoding ribozymes to a host. Most specifically, the invention relates to the use of target specific virions to package and deliver DNA comprising a target specific promoter and encoding a ribozyme(s) directed to the target organism nucleic acids. The present invention further relates to a novel vectors encoding a multi-ribozyme structure with enhanced 5? and/or 3? autocatalytically cleaving ribozymes.

Abstract: The invention provides methods and materials related to treating HPV infections (e.g., HPV infections of cutaneous and mucosal epithelial cells) and HPV-associated conditions (e.g., cervical dysplasia, HPV-associated cervical carcinomas, oral mucosal papilloma cancers, laryngeal papilloma cancers).

Abstract: The invention provides isolated nucleic acids. For example, the invention provides isolated nucleic acids having at least one strand with both sense and antisense sequences that are complementary to each other. The invention also provides isolated nucleic acids having at least one strand that is a template for both sense and antisense sequences that are complementary to each other. In addition, the invention provides cells, viruses, and transgenic animals (e.g., transgenic non-human animals) containing one or more of the isolated nucleic acids provided herein as well as methods for using one or more of the isolated nucleic acids provided herein to reduce the level of an RNA (e.g., an mRNA) within a cell.

Abstract: An electrical connector includes a main board (5) with a first card edge connector (1) mounted thereon, a sub-board (6) with a second card edge connector (2) mounted thereon, and a pair of complementary board to board connectors (3, 4) mounted on the main board (5) and the sub-board (6) respectively. The first and second card edge connectors (1, 2) are aligned with each other in a vertical direction and the second card edge connector (2) is on top of the first card edge connector (1).

Abstract: The present invention relates to the discovery, identification and characterization of toxic agents which are lethal to pathogens and methods for targeting such toxic agents to a pathogen or pathogen infected cells in order to treat and/or eradicate the infection. In particular, the present invention relates to toxic agents which target bacteria at different stages of the bacterial life cycle, which are delivered alone or in combination to bacteria or bacteria-infected cells. The invention relates to toxic agents which are lethal to diseased cells and methods for targeting such toxic agents to a diseased cell in order to treat and/or eradicate the disease. The present invention relates to promoter elements which are pathogen-specific or tissue-specific and the use of such promoter elements to achieve pathogen-specific or tissue-specific expression of the toxic agent(s) and/or ribozyme(s) of the present invention.

Abstract: An electrical connector includes a main board (5) with a first card edge connector (1) mounted thereon, a sub-board (6) with a second card edge connector (2) mounted thereon, and a pair of complementary board to board connectors (3, 4) mounted on the main board (5) and the sub-board (6) respectively. The first and second card edge connectors (1, 2) are aligned with each other in a vertical direction and the second card edge connector (2) is on top of the first card edge connector (1).

Abstract: The invention provides isolated nucleic acids. For example, the invention provides isolated nucleic acids having at least one strand with both sense and antisense sequences that are complementary to each other. The invention also provides isolated nucleic acids having at least one strand that is a template for both sense and antisense sequences that are complementary to each other. In addition, the invention provides cells, viruses, and transgenic animals (e.g., transgenic non-human animals) containing one or more of the isolated nucleic acids provided herein as well as methods for using one or more of the isolated nucleic acids provided herein to reduce the level of an RNA (e.g., an mRNA) within a cell.

Abstract: An electrical connector comprises an insulative housing, front and rear channels in the insulative housing and a hollow space defined between the front and corresponding rear channel, a plurality of front and rear contacts received respectively in said front and rear channels, said hollow space defines at least one block for separating the front and the rear contacts from each other, and avoid the front and rear contacts contacting each other for assuring the stable transmission of the signal.

Abstract: The present invention relates to the discovery, identification and characterization of toxic agents which are lethal to pathogens and methods for targeting such toxic agents to a pathogen or pathogen infected cells in order to treat and/or eradicate the infection. In particular, the present invention relates to toxic agents which target bacteria at different stages of the bacterial life cycle, which are delivered alone or in combination to bacteria or bacteria-infected cells. The invention relates to toxic agents which are lethal to diseased cells and methods for targeting such toxic agents to a diseased cell in order to treat and/or eradicate the disease. The present invention relates to promoter elements which are pathogen-specific or tissue-specific and the use of such promoter elements to achieve pathogen-specific or tissue-specific expression of the toxic agent(s) and/or ribozyme(s) of the present invention.

Abstract: An electrical connector adapted for mounting on a Printed Circuit Board (PCB), comprises an insulative housing, a plurality of terminals loaded in the insulative housing and a board lock device assembled in the insulative housing. The insulative housing comprises a base portion having a PCB mounting face and a mating portion extending from the base portion. The base portion defines a boardlock-receiving cavity and is formed with a block adjacent to the cavity. The board lock device comprises a retaining plate retained in the cavity and substantially parallel to the PCB mounting face of the base portion and a lock plate perpendicularly extending from the retaining plate beyond the PCB mounting face of the base portion for locking with the PCB. The retaining plate is supported by the block for preventing the board lock device from moving along a direction perpendicular to the PCB mounting face of the base portion.

Abstract: The invention provides methods and materials related to treating HPV infections (e.g., HPV infections of cutaneous and mucosal epithelial cells) and HPV-associated conditions (e.g., cervical dysplasia, HPV-associated cervical carcinomas, oral mucosal papilloma cancers, laryngeal papilloma cancers).

Abstract: An electrical connector adapted for mounting on a Printed Circuit Board (PCB), comprises an insulative housing, a plurality of terminals loaded in the insulative housing and a board lock device assembled in the insulative housing. The insulative housing comprises a base portion having a PCB mounting face and a mating portion extending from the base portion. The base portion defines a boardlock-receiving cavity and is formed with a block adjacent to the cavity. The board lock device comprises a retaining plate retained in the cavity and substantially parallel to the PCB mounting face of the base portion and a lock plate perpendicularly extending from the retaining plate beyond the PCB mounting face of the base portion for locking with the PCB. The retaining plate is supported by the block for preventing the board lock device from moving along a direction perpendicular to the PCB mounting face of the base portion.

Abstract: An electrical connector (1) includes a dielectric housing (10), a number of terminals (20) received in the dielectric housing and a pair of shielding plates attached to outer faces of the side walls. The dielectric housing includes a mating face, a pair of side walls extending from the mating face and a mating space in the mating face between the side walls. Each side wall includes a pair of protrusions and a recess in the outer face thereof. Each terminal includes a contact portion exposed to the mating space. Each shielding plate is formed with a retention blade engaging with the pair of protrusions and a spring tang received in the recess for preventing the shielding plate from moving away from the mating face.

Abstract: An electrical connector (1) includes an elongate insulative housing (10), a number of contacts (20), and a shell (30). The insulative housing has a bottom wall (11) and two side walls (12) extending upwardly from the bottom wall. The contacts include signal contacts (21) and grounding contacts (22). Each contact has an engaging portion received in the insulative housing and a soldering portion extending outwardly and horizontally from the bottom wall. The shell is assembled to exterior surfaces of the side walls and comprises a plurality of grounding fingers (31) and a pair of cut portions (33). A distant is existed between a bottom surface of the bottom wall and each cut portion.

Abstract: An electrical connector includes a dielectric housing defining a mating space with a pair of two opposite side wall by two sides thereof, a plurality of passageways formed in an inner face of each of the side walls, a number of signal and grounding terminals received in corresponding passageways, respectively, a shielding member attached to the side walls and a grounding member. Each grounding member includes an intermediate portion and three spaced beams extending from a side of the intermediate portion along a same direction. A middle one of the three beams is snugly retained in corresponding channel. The other two beams electrically and mechanically press the grounding terminal and the shield plate against the side wall, respectively.

Abstract: The present invention relates to the discovery, identification and characterization of toxic agents which are lethal to pathogens and methods for targeting such toxic agents to a pathogen or pathogen infected cells in order to treat and/or eradicate the infection. In particular, the present invention relates to toxic agents which target bacteria at different stages of the bacterial life cycle, which are delivered alone or in combination to bacteria or bacteria-infected cells. The invention relates to toxic agents which are lethal to diseased cells and methods for targeting such toxic agents to a diseased cell in order to treat and/or eradicate the disease. The present invention relates to promoter elements which are pathogen-specific or tissue-specific and the use of such promoter elements to achieve pathogen-specific or tissue-specific expression of the toxic agent(s) and/or ribozyme(s) of the present invention.

Abstract: An electrical connector (1) includes a dielectric housing (10), a number of terminals (20) received in the dielectric housing and a pair of shielding plates attached to outer faces of the side walls. The dielectric housing includes a mating face, a pair of side walls extending from the mating face and a mating space in the mating face between the side walls. Each side wall includes a pair of protrusions and a recess in the outer face thereof. Each terminal includes a contact portion exposed to the mating space. Each shielding plate is formed with a retention blade engaging with the pair of protrusions and a spring tang received in the recess for preventing the shielding plate from moving away from the mating face.

Abstract: An electrical connector includes a dielectric housing defining a mating space with a pair of two opposite side wall by two sides thereof, a plurality of passageways formed in an inner face of each of the side walls, a number of signal and grounding terminals received in corresponding passageways, respectively, a shielding member attached to the side walls and a grounding member. Each grounding member includes an intermediate portion and three spaced beams extending from a side of the intermediate portion along a same direction. A middle one of the three beams is snugly retained in corresponding channel. The other two beams electrically and mechanically press the grounding terminal and the shield plate against the side wall, respectively.