Abstract: Systems and methods for facilitating video compression in screen-sharing applications are provided. In one embodiment, a method includes: determining properties of a screen, and determining properties of display regions configured for display via the screen. The method also includes generating reference buffers corresponding to the respective display regions. The reference buffers can be associated with: identifiers of the display region, and encoded bitstreams for the display regions. The encoded bitstreams can be indicative of the properties of the display regions and/or screen. The method can also include determining whether the display regions are configured to be visible or invisible on the screen, and generating the encoded bitstream for each of the display regions configured to be visible on the screen. Finally, the method can include performing video compression on contents of the display regions.