Patents by Inventor Wei-Lien Chuang

Wei-Lien Chuang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TWO-DIMENSIONAL LC-MS/MS SYSTEMS
    Publication number: 20220252559
    Abstract: The present invention relates to a novel analytical method for detecting one or more analytes in a source sample by continuous flow 2D LC-MS/MS using a single LC system.
    Type: Application
    Filed: May 29, 2020
    Publication date: August 11, 2022
    Applicant: Genzyme Corporation
    Inventors: Wei-Lien Chuang, Felipe Gazos Lopes, Joshua Pacheco, Gerard Sanderink
  • MARKER FOR ACID SPHINGOMYELINASE DISORDERS AND USES THEREOF
    Publication number: 20210162021
    Abstract: The present disclosure provides methods of screening, diagnosing, monitoring and/or treating acid sphingomyelinase (ASM) disorders such as Niemann-Pick disease. In particular, the methods encompass techniques for improved diagnosis and/or treatment of an ASM disorder, for example using enzyme replacement therapy.
    Type: Application
    Filed: December 11, 2020
    Publication date: June 3, 2021
    Applicant: Genzyme Corporation
    Inventors: Wei-Lien Chuang, Gerald F. Cox, X. Kate Zhang
  • Marker for acid sphingomyelinase disorders and uses thereof
    Patent number: 10888607
    Abstract: The present disclosure provides methods of screening, diagnosing, monitoring and/or treating acid sphingomyelinase (ASM) disorders such as Niemann-Pick disease. In particular, the methods encompass techniques for improved diagnosis and/or treatment of an ASM disorder, for example using enzyme replacement therapy.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: January 12, 2021
    Assignee: Genzyme Corporation
    Inventors: Wei-Lien Chuang, Gerald F. Cox, X. Kate Zhang
  • Marker for Acid Sphingomyelinase Disorders and Uses Thereof
    Publication number: 20180289778
    Abstract: The present disclosure provides methods of screening, diagnosing, monitoring and/or treating acid sphingomyelinase (ASM) disorders such as Niemann-Pick disease. In particular, the methods encompass techniques for improved diagnosis and/or treatment of an ASM disorder, for example using enzyme replacement therapy.
    Type: Application
    Filed: June 8, 2018
    Publication date: October 11, 2018
    Applicant: Genzyme Corporation
    Inventors: Wei-Lien CHUANG, Gerald F. COX, X. Kate ZHANG
  • Marker for acid sphingomyelinase disorders and uses thereof
    Patent number: 10022428
    Abstract: The present disclosure provides methods of screening, diagnosing, monitoring and/or treating acid sphingomyelinase (ASM) disorders such as Niemann-Pick disease. In particular, the methods encompass techniques for improved diagnosis and/or treatment of an ASM disorder, for example using enzyme replacement therapy.
    Type: Grant
    Filed: June 6, 2014
    Date of Patent: July 17, 2018
    Assignee: GENZYME CORPORATION
    Inventors: Wei-Lien Chuang, Gerald F. Cox, X. Kate Zhang
  • MARKER FOR ACID SPHINGOMYELINASE DISORDERS AND USES THEREOF
    Publication number: 20160120958
    Abstract: The present disclosure provides methods of screening, diagnosing, monitoring and/or treating acid sphingomyelinase (ASM) disorders such as Niemann-Pick disease. In particular, the methods encompass techniques for improved diagnosis and/or treatment of an ASM disorder, for example using enzyme replacement therapy.
    Type: Application
    Filed: June 6, 2014
    Publication date: May 5, 2016
    Applicant: Genzyme Corporation
    Inventors: Wei-Lien CHUANG, Gerald F. COX, Kate X. ZHANG
  • Compositions and methods for detection of lysosomal storage disease
    Patent number: 8431335
    Abstract: The present invention provides compositions for performing assays of enzyme activity associated with lysosomal storage diseases. The invention further provides methods for determining enzyme activity, and methods for the screening for lysosomal storage disease in an individual.
    Type: Grant
    Filed: September 12, 2007
    Date of Patent: April 30, 2013
    Assignee: Genzyme Corporation
    Inventors: Xiaokui K. Zhang, Wei-Lien Chuang, Joan Keutzer
  • Methods for detection of lysosomal storage disease
    Publication number: 20080248513
    Abstract: The present invention provides compositions for performing assays of enzyme activity associated with lysosomal storage diseases. The invention further provides methods for determining enzyme activity, and methods for the screening for lysosomal storage disease in an individual.
    Type: Application
    Filed: September 12, 2007
    Publication date: October 9, 2008
    Inventors: Xiaokui K. Zhang, Wei-Lien Chuang, Carole S. Elbin, Daniel Scheidegger, Christa Beauregard, Sharon Pickering, Joshua Pacheco, Joan Keutzer
  • Methods for detection of lysosomal storage disease
    Publication number: 20080248512
    Abstract: The present invention provides compositions for performing assays of enzyme activity associated with lysosomal storage diseases. The invention further provides methods for determining enzyme activity, and methods for the screening for lysosomal storage disease in an individual.
    Type: Application
    Filed: September 12, 2007
    Publication date: October 9, 2008
    Applicant: Genzyme Corporation
    Inventors: Xiaokui K. Zhang, Wei-Lien Chuang, Carole S. Elbin, Daniel Scheidegger, Christa Beauregard, Sharon Pikering, Joshua Pacheco, Joan Keutzer
  • Compositions and methods for detection of lysosomal storage disease
    Publication number: 20080145836
    Abstract: The present invention provides compositions for performing assays of enzyme activity associated with lysosomal storage diseases. The invention further provides methods for determining enzyme activity, and methods for the screening for lysosomal storage disease in an individual.
    Type: Application
    Filed: September 12, 2007
    Publication date: June 19, 2008
    Applicant: Genzyme Corporation
    Inventors: Xiaokui K. Zhang, Wei-Lien Chuang, Carole S. Elbin, Daniel Scheidegger, Christa Beauregard, Sharon Pickering, Joshua Pacheco, Joan Keutzer