Abstract: A package structure is provided. The package structure includes a substrate, a first electronic component, a first electrical connector, and a protective layer. The first electronic component is over the substrate. The first electrical connector is between the substrate and the first electronic component. The protective layer encapsulates the first electrical connector. The protective layer has a first curved lateral surface concave toward the first electrical connector and recessed with respect to a lateral surface of the first electronic component.

Abstract: Provided are K-Ras mutant protein inhibitors of formula (I), a composition containing the same and the use thereof.

Abstract: Disclosed is a full-length vibration excitable component device for measuring the strength of a rock and a cementitious material. The device comprises a steel rod member (1), a vehicle body (2), a vibration motor (3), a frequency measurement element (4), and an integrated lead harness (5); wherein, the steel rod member (1) has a through slot (6) in its interior, the vehicle body (2) is placed in the through slot (6), and the top of the vehicle body (2) is provided with a first mounting slot and a second mounting slot.

Abstract: A Compound of formula (I) or (II), a stereoisomer thereof, an atropisomer, a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable salt of the stereoisomer, a pharmaceutically acceptable salt of the atropisomer, a prodrug thereof, a deuterated molecule thereof or a conjugated form thereof is disclosed:

Abstract: An exhaust discharging device with a temperature control and heat retention mechanism for preventing photoresist from crystallization that causes duct adhesion and its exhaust discharging method involve a flow guiding portion, a flow control portion and an out-flowing gas guiding portion. Photoresist-containing exhaust is guided into the flow guiding portion, and undergoes flow division twice. After the temperature of the flow guiding portion, flow control portion and out-flowing gas guiding portion are directly or indirectly increased, the environmental temperature in their ductway is in a first temperature range, second temperature range and third temperature range, respectively. The heat retention material layer of the out-flowing gas guiding portion blocks thermal conduction with the outside.

Abstract: Provided are compounds of formula (I) which can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. Also provided are pharmaceutical compositions comprising the compounds, methods of preparing the compounds and the use in the manufacture of medicaments for preventing or treating a disease or condition related to p53 mutants.

Abstract: Provided herein are salts of the compound 1 and new poly morph forms thereof, pharmaceutical composition including the compound 1 and new polymorph forms thereof, and methods of preparing them and using them.

Abstract: Provided herein is a compound of Formula (IB), a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable salt of the stereoisomer thereof, a prodrug thereof, a deuterated molecule thereof or a conjugated form thereof; composition containing the same and the use thereof.

Abstract: A light emitting device controls its mixed CCT by the configuration of at least one light emitter, at least one diode and at least two power distribution components. The present disclosure is mainly based on the hardware design of diode and jumper, which effectively replaces the resistors and manual switches of the conventional light emitting device with diodes, wherein the resistors and the manual switches of the conventional light emitting device cause voltage instability and other problems. The present disclosure can achieve the demand for miniaturization of the light emitting device by plugging the jumper into pins, and further can achieve the main advantages of stabilizing the voltage of the overall light emitting device, thereby stabilizing the luminous performance of the overall light emitting device, and emitting the mixed light with the required CCT. The present disclosure also illustrates a lamp assembly using the aforementioned light emitting device.

Abstract: The present disclosure, in some embodiments, relates to an image sensor integrated chip. The image sensor integrated chip includes a plurality of gate structures arranged along a first side of a substrate within a plurality of pixel regions. An etch block structure is arranged on the first side of the substrate between neighboring ones of the plurality of gate structures. A contact etch stop layer (CESL) is arranged on the etch block structure between the neighboring ones of the plurality of gate structures. An isolation structure is disposed between one or more sidewalls of the substrate and extends from a second side of the substrate to the first side of the substrate. The etch block structure is vertically between the isolation structure and the CESL.

Abstract: A health care device illustrated has a low-frequency wave emitter, a low-frequency waveguide and a plant essential oil carrier disposed between the low-frequency wave emitter and the low-frequency waveguide. The low-frequency wave emitter emits a low-frequency wave with a predetermined frequency, and the low-frequency wave firstly passes through the plant essential oil carrier, and then propagates to the low-frequency waveguide. Next, energy of the low-frequency wave is focused in the low-frequency waveguide, and then the low-frequency wave is emitted out from the low-frequency waveguide. A health care method illustrated emits the low-frequency wave with the predetermined frequency to a belly button of a user by using the health care device. The health care device and method increase contents of NAD+ in blood of the user, and achieve effects of convenient operation, accurate use position identification, and non-invasive and non-contact health care.

Abstract: Provided are a compound of formula (I) that inhibit the activity of PARP7, a stereoisomer thereof, a deuterated derivative thereof, or a pharmaceutically acceptable salt thereof, an intermediate to prepare the compound, a process to prepare the compound, a composition comprising the same, and the methods of using the same.

Abstract: A burner of a gas stove includes a burner body, a partition member, and at least one flame cover. The burner body includes a gas conduit and a base. The gas conduit has at least one gas input passage for injecting gas and air, and the base has at least one mixture passage for mixing the gas and the air. The at least one mixture passage communicates with the at least one gas input passage. The partition member has a plurality of through holes and covers the at least one mixture passage. The at least one flame cover provided with a plurality of flame holes covers the partition member. Whereby, the size of the burner of the gas stove is reduced significantly, and the gas can mix with the air effectively and uniformly.

Abstract: A navigation system includes: a control circuit configured to: a control circuit configured to: capture a semantic frame from a sensor data stream for a region of interest, calculate a score (EQ1) for semantic points in the semantic frame, align the semantic points includes a pose error corrected, generate a semantic grid map of the semantic points including a high-level grid and a low-level grid, calculate grid map statistics by counting the semantic points in the low-level grid within the high-level grid, filter the semantic points in the low-level grid based on the grid map statistics of the high-level grid, and generate a semantic map from the low-level grid filtered and the high-level grid; and a communication circuit, coupled to the control circuit, configured to: process the semantic frame through a network, and process the semantic map through the network for displaying on a device.

Abstract: A navigation system includes: a control circuit configured to: a control circuit configured to: capture a semantic frame from a sensor data stream for a region of interest, crop an outer peripheral edge of the semantic frame by removing semantic points beyond the outer peripheral edge, calculate a world coordinate point cloud by calculating a global positioning system (GPS) location of the semantic points includes a pose error corrected, establish a probability value for a base-level grid, generate a semantic grid map by identifying a dominant percentage of the probability value of the base-level grid and an upper-level grid, and generate a semantic map from the semantic grid map to represent the region of interest; and; and a communication circuit, coupled to the control circuit, configured to transmit the semantic map for displaying on a device.

Abstract: Disclosed is a full-length vibration excitable component device for measuring the strength of a rock and a cementitious material. The device comprises a steel rod member (1), a vehicle body (2), a vibration motor (3), a frequency measurement element (4), and an integrated lead harness (5); wherein, the steel rod member (1) has a through slot (6) in its interior, the vehicle body (2) is placed in the through slot (6), and the top of the vehicle body (2) is provided with a first mounting slot and a second mounting slot.

Abstract: The present disclosure is drawn to bio-ink printer components, methods of printing bio-inks, and multi-fluid live cell printing systems. In one example, a bio-ink printer component can include a bio-ink and a bio-ink ejector fluidly connected or connectable to the bio-ink. The bio-ink can include a buffer solution that is suitable for live cells, and a polymer that includes polyvinylpyrrolidone, polyvinyl alcohol, polyvinyl sulfate, polyethylene glycol, polyester, poly(dimethylsiloxane), cellulose, polysaccharide, or a combination thereof. The bio-ink ejector can include an ejection nozzle and a thermal resistor positioned to heat the bio-ink to form a vapor bubble to eject a droplet of bio-ink from the ejection nozzle.

Abstract: The invention relates to a KRAS G12D inhibitors of formula (I) or formula (IV), a composition containing the inhibitor and the use thereof

Abstract: Compounds of general Formula S-1, S-2, S-3 and their pharmaceutically acceptable salts, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are synthesis, compositions, and uses of such compounds.