Abstract: A composition containing recombinant collagen with repairing and soothing effects, eye cream containing the composition and preparation method thereof are provided. The composition contains the following raw materials in parts by weight: 1 to 10 parts of recombinant collagen, 1 to 10 parts of sodium hyaluronate, 1 to 5 parts of bifida ferment lysate, 1 to 15 parts of glucosylglycerol, 1 to 10 parts of bisabolol, 1 to 15 parts eight-treasure essence stock solution, and 1 to 15 parts of pink red plum rechecking essence. The composition features with good skin permeability, contributing to its significant effects on repairing skin barriers and relieving skin inflammation, as well as its advantages of low irritation and high safety. Thus, the composition is suitable for people with damaged eye skin and has good market application prospects.

Abstract: Provided is an oral Pt(IV) anticancer prodrug containing a 3-bromopyruvate as an axial ligand, with a molecular formula of cis,trans,cis-[Pt(1R,2R-diaminocyclohexane)(OH)(3-bromopyruvate)(C2O4)]. It is a prodrug of oxaliplatin and 3-bromopyruvic acid is a small molecular glycolysis inhibitor. The prodrug is able to simultaneously act on DNA replication and glycolytic pathways of cancer cells, giving full play to the advantage of double-acting targets. The oral Pt(IV) anticancer prodrug is synthesized by using oxaliplatin as a starting material, performing axial oxidation with H2O2 and neutralizing the oxidized product with 3-bromopyruvic acid.

Abstract: Provided are a water-soluble Pd(II) complex, a synthesis method thereof and use thereof as a catalytic precursor. The complex has a chemical name, ammonium dinitrooxalato palladium (II), and a molecular formula of (NH4)2[Pd(NO2)2(C2O4)]·nH2O (n is the number of crystal water). The Pd(II) complex is synthesized by using PdCl2 or [Pd(NH3)2Cl2] as a starting material which is firstly converted into [Pd(NH3)4]Cl2 in ammonium hydroxide, followed by a chemical reaction between [Pd(NH3)4]Cl2 and excessive NaNO2 to produce trans-[Pd(NH3)2(NO2)2] via ligand substitution mechanism, and finally dissolving trans-[Pd(NH3)2(NO2)2] in an aqueous solution of oxalic acid leads to the formation of the target product (NH4)2[Pd(NO2)2(C2O4)]·2H2O. The complex does not contain chlorine and other elements that are harmful to a catalyst, is readily soluble in water and has a low thermal decomposition temperature.

Abstract: The present invention discloses a group of polycyclic carbamoylpyridone derivatives, pharmaceutical compositions, and a use thereof. The structure of the polycyclic carbamoylpyridone derivatives of the present invention is represented by formula (VII). The polycyclic carbamoylpyridone derivative of the present invention functions as an inhibitor of influenza 5?cap-like structure (CAP)-dependent endonuclease activity and can be used to treat a cold caused by the influenza virus. The present invention also discloses a pharmaceutical composition to inhibit proliferation of the influenza virus.

Abstract: The present invention relates to the sector of building materials, and more specifically, to a floor connector and a floor with the floor connector. The floor connector includes a first connecting part and a second connecting part used to connect floors, and a supporting part arranged between the bottom surface of the first connecting part and the upper surface of the second connecting part for the purpose of supporting the first connecting part and the second connecting part. The floor includes a main body, a floor pedestal arranged under the main body, and a floor connector used to connect the main body and the floor pedestal. In this solution, the floor can be arranged without a keel, thereby significantly reducing the labor intensity during floor installation. Consisting of three parts, the floor features lightweight and simplification of installation procedure.

Abstract: The present invention relates to the sector of building materials, and more specifically, to a floor connector and a floor with the floor connector. The floor connector includes a first connecting part and a second connecting part used to connect floors, and a supporting part arranged between the bottom surface of the first connecting part and the upper surface of the second connecting part for the purpose of supporting the first connecting part and the second connecting part. The floor includes a main body, a floor pedestal arranged under the main body, and a floor connector used to connect the main body and the floor pedestal. In this solution, the floor can be arranged without a keel, thereby significantly reducing the labor intensity during floor installation. Consisting of three parts, the floor features lightweight and simplification of installation procedure.

Abstract: Purine derivatives of formula I, substituted at the 9-position, are prepared from a chloro substituted purine starting material, first making an alkyl substitution at the 9-position, then forming the desired esterified side chain, reducing this and hydrogenating the resultant diol prior to addition of alkyl carbonyl groups.

Abstract: Purine derivatives, substituted at the 9-position, are prepared from a chloro substituted purine starting material, first making an alkyl substitution at the 9-position, then forming the desired esterified side chain, reducing this and hydrogenating the resultant diol prior to addition of alkyl carbonyl groups.