Abstract: The present invention relates to oral compositions comprising cabozantinib salts and at least one pharmaceutically acceptable excipient and methods of using the oral compositions to increase the oral bioavailability of the cabozantinib and reduce the adverse events associate with the oral administration of cabozantinib. The invention also relates to methods for preparing cabozantinib lauryl sulfate salts.

Abstract: The present invention relates to oral compositions comprising cabozantinib salts and at least one pharmaceutically acceptable excipient and methods of using the oral compositions to increase the oral bioavailability of the cabozantinib and reduce the adverse events associate with the oral administration of cabozantinib. The invention also relates to methods for preparing cabozantinib lauryl sulfate salts.

Abstract: A system includes a heater configured to heat a fluid of a lubricant system, a controller coupled to the heater, the controller including at least one processor coupled to at least one memory device storing instructions that, when executed by the at least one processor, cause the controller to perform operations including: receiving information regarding an engine operating parameter of an engine, receiving information regarding an operating parameter of the lubricant system, and activating the heater responsive to determining that at least one of the engine operating parameter or the operating parameter of the lubricant system is at or below a predefined threshold.

Abstract: Implementations of the present specification provide a computing task processing method and apparatus. In the computing task processing method, a first computing task can be obtained, and the first computing task includes a first operator execution logic graph used for task computing; operator reconstruction is performed on the first operator execution logic graph based on an operator dependency in the first operator execution logic graph and a data cache capacity for operator computing, to obtain a second operator execution logic graph; and a second computing task including the second operator execution logic graph is provided to a task execution apparatus for execution by the task execution apparatus.

Abstract: An engineered DNA molecule capable of being replicated in a cell, comprising a poly (A) tail coding sequence that makes the engineered DNA molecule more conservative when replicated in cells, particularly in prokaryotic cells, while adjusting the expression level of RNA in eukaryotic cells. Also provided are an RNA comprising the poly (A) tail and a use thereof.

Abstract: A computer cluster is configured to perform distributed computing on graph data, the computer cluster includes a first computer and a second computer, the first computer is configured to process a vertex in a first vertex set in the graph data, the second computer is configured to process a vertex in a second vertex set in the graph data, the first vertex set includes a first source vertex, the second vertex set includes a first destination vertex corresponding to the first source vertex. A communication method includes: generating information of the first source vertex; determining the second computer based on pre-recorded mapping relationship information, where the second computer is configured to process information of the first destination vertex; and sending a first communication message to the second computer, where the first communication message includes the information of the first source vertex.

Abstract: A display substrate and a display device. The display substrate includes a pixel circuit in which the driving circuit controls a driving current driving the light emitter element to emit light; the first light emission control circuit applies a first voltage to a first terminal of the driving circuit in response to a first light emission control signal; the second light emission control circuit applies the driving current to the light emitter element in response to a second light emission control signal; the first reset circuit applies a first reset voltage to the control terminal of the driving circuit in response to a first reset signal; the first reset signal and the first light emission control signal are simultaneously turn-on signals during a period; the first light emission control line and the second light emission control line extend along a first direction and are arranged in a second direction.

Abstract: A display panel includes a base substrate and a plurality of sub-pixel groups. The plurality of sub-pixel groups includes a first sub-pixel group and a second sub-pixel group. The first sub-pixel group includes two adjacent sub-pixels with a first interval therebetween, and the second sub-pixel group includes two adjacent sub-pixels with a second interval therebetween. The first interval is different from the second interval.

Abstract: A method for in-situ swath positioning includes generating an in-situ swath positioning database by selecting a plurality of high contrast alignment targets from a set of pixel-to-design alignment images within a pixel-to-design alignment database. The method includes performing a first runtime swath of a plurality of runtime dies, where each runtime frame associated with the first runtime swath includes a high contrast alignment target from the in-situ swath positioning database. The method may include determining one or more offset values for each runtime die based on the plurality of high contrast alignment targets and one or more runtime frames associated with the first runtime swath. The one or more offset values may include an x-offset value and a y-offset value for each die. The method may include adjusting an initial stage position based on the determined one or more offset values prior to performing a second runtime swath.

Abstract: Provided is a method for producing tetrafluoromethane through plasma pyrolysis of waste polytetrafluoroethylene (PTFE), relating to the technical field of waste recycling. The method of the disclosure includes: subjecting the waste PTFE to a plasma pyrolysis reaction to obtain a pyrolysis product, and subjecting the pyrolysis product to quenching and gas-solid separation in sequence to obtain a pyrolysis gas including the tetrafluoromethane, wherein the plasma pyrolysis reaction is performed at a temperature of 1,800 K to 5,000 K. The method provided by the disclosure has advantages such as a high conversion rate, a short reaction time, a large treatment capacity, high reaction safety, easy product purification, and suitable for continuous industrial scale-up, and can realize the recycling of waste PTFE with a low energy consumption and a low cost. In addition, the method of the disclosure avoids the fluorine waste caused by incineration and leads to a high value-added tetrafluoromethane product.

Abstract: A wire bonding system is provided. The wire bonding system includes (i) a bond head assembly configured to carry a wire bonding tool; and (il) a wire bonding tool replacement system for replacement of the wire bonding tool with another wire bonding tool.

Abstract: The present disclosure relates to a hysteretance component, which is designed based on its definition, calculation formulas, and port characteristics. By increasing or decreasing hysteretance components in a magnetic circuit, the intensity and effect magnitude of magnetic hysteresis in a vector magnetic circuit can be estimated and controlled from the perspective of magnetic circuit, allowing the vector state of a magnetic flux to be consistent with the desired state. Based on this, an application method is proposed, involving that a target magnetic circuit is formed by connecting reluctance, magductance, and hysteretance components in series, and magnetic circuit parameters of the three components are utilized to quantitatively express magnetization, eddy current, and magnetic hysteresis phenomena, enabling technicians to selectively alter the operating characteristics of the magnetic circuit, vector magnetic quantities, and power of the magnetic circuit by adjusting the parameters.

Abstract: A wireless communication method includes after a master device establishes a wireless connection to a slave device, performing negotiation on sound effect processing The master device determines, based on indication information fed back by the slave device, whether joint sound effect processing can be performed between the master device and the slave device. If joint sound effect processing can be performed, the method includes performing adaptive sound effect processing on both master device and slave device sides.

Abstract: A display substrate and a display device. The display substrate includes a pixel circuit in which the driving circuit controls a driving current driving the light emitter element to emit light; the first light emission control circuit applies a first voltage to a first terminal of the driving circuit in response to a first light emission control signal; the second light emission control circuit applies the driving current to the light emitter element in response to a second light emission control signal; the first reset circuit applies a first reset voltage to the control terminal of the driving circuit in response to a first reset signal; the first reset signal and the first light emission control signal are simultaneously turn-on signals during a period; the first light emission control line and the second light emission control line extend along a first direction and are arranged in a second direction.

Abstract: A display substrate and a display device are disclosed. The display substrate includes a light-transmitting region, wherein the light-transmitting region includes a plurality of rows of effective sub-pixel sets and a plurality of main spacers, each row of the plurality of rows of effective sub-pixel sets includes a plurality of effective sub-pixel sets, each of the plurality of effective sub-pixel sets includes a plurality of effective sub-pixels, any two adjacent effective sub-pixel sets in a same row are spaced apart from each other by one main spacer, the main spacer includes at least two sub-spacers arranged along a column direction. At least two sub-spacers arranged along a row direction have different widths; and/or at least two sub-spacers of a same main sub-spacer have different widths.

Abstract: A method of determining a sequence for creating a plurality of wire loops is provided. The method includes (a) providing workpiece data for a workpiece. The workpiece data includes (i) position data for bonding locations of the workpiece, and (ii) wire loop data for a plurality of wire loops providing interconnection between ones of the bonding locations. The method also includes (b) analyzing the workpiece data. The step of analyzing includes considering overlap conditions between ones of the plurality of wire loops, considering wire loop heights of ones of the plurality of wire loops, considering lateral bend conditions between ones of the plurality of wire loops, and considering wire loop positions for ones of the plurality of wire loops. The method also includes (c) providing a sequence of creating the plurality of wire loops in connection with the workpiece at least partially based on the results of step (b).

Abstract: The present invention relates to oral compositions comprising cabozantinib salts and at least one pharmaceutically acceptable excipient and methods of using the oral compositions to increase the oral bioavailability of the cabozantinib and reduce the adverse events associate with the oral administration of cabozantinib. The invention also relates to methods for preparing cabozantinib lauryl sulfate salts.