Abstract: The invention relates to the field of biomedicine, in particular to an enhanced synthetic T-cell receptor and antigen receptor (STAR) targeting CD19 and CD20, a T cell comprising the synthetic T-cell receptor antigen receptor and the use thereof.

Abstract: The present invention relates to the field of biomedicine, to an improved T cell receptor-costimulatory molecule chimera, in particular to a T cell receptor (TCR) or TCR complex comprising a costimulatory molecule, a T cell comprising the TCR or TCR complex, and the use thereof.

Abstract: The invention relates to the field of biomedicine, in particular to a T cell co-expressing CXCR2 and a Synthetic T-Cell Receptor and Antigen Receptor (STAR) against GPC3, and uses thereof.

Abstract: A computing system may be configured to store a master session context of a HyperText Transfer Protocol (HTTP) session, and a queue of HTTP transactions. A middleware module of the computing system may be executable by the processor to: (i) select a first HTTP transaction from the queue, (ii) execute an exclusive phase of the first HTTP transaction, including copying the master session context into a first local session context, (iii) cause a web server to execute a non-exclusive phase of the first HTTP transaction using a first thread and the first local session context, (iv) select a second HTTP transaction from the queue, and (v) execute an exclusive phase of the second HTTP transaction, including copying the master session context into a second local session context. Execution of the exclusive phase of the second HTTP transaction and the execution of the non-exclusive phase of the first HTTP transaction occur concurrently.

Abstract: A client instance provides search suggestions based on a partial search query. The search suggestions include user search suggestions based on previous search queries performed by the user and instance search suggestions based on previous search queries performed on the instance. The client instance filters the instance search suggestions based on filter criteria associated with the user, such as an interface used by the user, a search context, user group that the user belongs to, domain used by the user, and so on. The client instance may remove the search suggestions that include blacklisted terms. The client instance may rank the search suggestions (e.g., based on frequency and/or recency) and enable the user to select those ranked search suggestions that meet or exceed a threshold.

Abstract: A computing system may be configured to store a master session context of a HyperText Transfer Protocol (HTTP) session, and a queue of HTTP transactions. A middleware module of the computing system may be executable by the processor to: (i) select a first HTTP transaction from the queue, (ii) execute an exclusive phase of the first HTTP transaction, including copying the master session context into a first local session context, (iii) cause a web server to execute a non-exclusive phase of the first HTTP transaction using a first thread and the first local session context, (iv) select a second HTTP transaction from the queue, and (v) execute an exclusive phase of the second HTTP transaction, including copying the master session context into a second local session context. Execution of the exclusive phase of the second HTTP transaction and the execution of the non-exclusive phase of the first HTTP transaction occur concurrently.