Patents by Inventor Wei-Shu Lu

Wei-Shu Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and pharmaceutical compositions for preventing or treating immunoinflammatory dermal disorders
    Patent number: 10675260
    Abstract: A method for preventing or treating immunoinflammatory dermal disorders is provided. Also provided is a pharmaceutical composition for preventing or treating immunoinflammatory dermal disorders.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: June 9, 2020
    Assignee: TWi Biotechnology, Inc.
    Inventors: Po-Yuan Tseng, Wei-Shu Lu, Carl Oscar Brown, III, I-Yin Lin, III, Chen-En Tsai, Chih-Kuang Chen
  • Diacerein or rhein topical formulations and uses thereof
    Patent number: 10512625
    Abstract: A topical pharmaceutical composition containing diacerein and/or its analogs is provided. Also provided is a method for treating various diseases using this topical pharmaceutical composition.
    Type: Grant
    Filed: December 6, 2018
    Date of Patent: December 24, 2019
    Assignee: TWI BIOTECHNOLOGY, INC.
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • DIACEREIN OR RHEIN TOPICAL FORMULATIONS AND USES THEREOF
    Publication number: 20190105296
    Abstract: A topical pharmaceutical composition containing diacerein and/or its analogs is provided. Also provided is a method for treating various diseases using this topical pharmaceutical composition.
    Type: Application
    Filed: December 6, 2018
    Publication date: April 11, 2019
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • Methods for inhibiting expression of ASC, expression of NLRP3, and/or formation of NLRP3 inflammasome complex using diacerein or its analogs
    Patent number: 10195170
    Abstract: Methods and compositions for inhibiting expression of ASC, expression of NLRP3, and/or formation of NLRP3 inflammasome complex by using diacerein or its analogs are provided. Also provided are methods and compositions for the treatment and/or prevention of a disorder mediated by ASC and/or NLRP3, and/or by formation of NLRP3 inflammasome complex by using diacerein or its analogs.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: February 5, 2019
    Assignee: TWI Biotechnology, Inc.
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • Diacerein or Rhein topical formulations and uses thereof
    Patent number: 10154984
    Abstract: A topical pharmaceutical composition containing diacerein and/or its analogs is provided. Also provided is a method for treating various diseases using this topical pharmaceutical composition.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: December 18, 2018
    Assignee: TWi Biotechnology, Inc.
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • METHODS AND PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING IMMUNOINFLAMMATORY DERMAL DISORDERS
    Publication number: 20180200235
    Abstract: A method for preventing or treating immunoinflammatory dermal disorders is provided.
    Type: Application
    Filed: January 19, 2018
    Publication date: July 19, 2018
    Inventors: Po-Yuan Tseng, Wei-Shu Lu, Carl Oscar Brown, III, I-Yin Lin, III, Chen-En Tsai, Chih-Kuang Chen
  • DIACEREIN OR RHEIN TOPICAL FORMULATIONS AND USES THEREOF
    Publication number: 20180021290
    Abstract: A topical pharmaceutical composition containing diacerein and/or its analogs is provided. Also provided is a method for treating various diseases using this topical pharmaceutical composition.
    Type: Application
    Filed: July 25, 2017
    Publication date: January 25, 2018
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • METHODS AND FORMULATIONS FOR TREATMENT AND/OR PREVENTION OF BLOOD-ASSOCIATED DISORDERS
    Publication number: 20170319532
    Abstract: A method of treating and/or preventing blood-associated disorders is provided. Also provided is a method of treating and/or preventing hemophilic arthropathy and/or hemochromatosis arthropathy in a subject.
    Type: Application
    Filed: May 5, 2017
    Publication date: November 9, 2017
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • Diacerein or rhein topical formulations and uses thereof
    Patent number: 9744131
    Abstract: A topical pharmaceutical composition containing diacerein and/or its analogs is provided. Also provided is a method for treating various diseases using this topical pharmaceutical composition.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: August 29, 2017
    Assignee: TWi Biotechnology, Inc.
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • METHODS FOR INHIBITING EXPRESSION OF ASC, EXPRESSION OF NLRP3, AND/OR FORMATION OF NLRP3 INFLAMMASOME COMPLEX USING DIACEREIN OR ITS ANALOGS
    Publication number: 20170049733
    Abstract: Methods and compositions for inhibiting expression of ASC, expression of NLRP3, and/or formation of NLRP3 inflammasome complex by using diacerein or its analogs are provided. Also provided are methods and compositions for the treatment and/or prevention of a disorder mediated by ASC and/or NLRP3, and/or by formation of NLRP3 inflammasome complex by using diacerein or its analogs.
    Type: Application
    Filed: August 17, 2016
    Publication date: February 23, 2017
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • DIACEREIN OR RHEIN TOPICAL FORMULATIONS AND USES THEREOF
    Publication number: 20170000732
    Abstract: A topical pharmaceutical composition containing diacerein and/or its analogs is provided. Also provided is a method for treating various diseases using this topical pharmaceutical composition.
    Type: Application
    Filed: June 30, 2016
    Publication date: January 5, 2017
    Inventors: Chih-Kuang Chen, Jing-Yi Lee, Wei-Shu Lu, Carl Oscar Brown, III
  • FORMULATIONS CONTAINING DIACEREIN AND METHODS OF LOWERING BLOOD LEVELS OF URIC ACID USING THE SAME
    Publication number: 20160303050
    Abstract: A controlled-release formulation containing diacerein or its analogs is provided. Also provided is a method of lowering blood levels of uric acid using this formulation.
    Type: Application
    Filed: April 20, 2015
    Publication date: October 20, 2016
    Inventors: Hanpin Lim, Carl Oscar Brown, III, Wei-Shu Lu, Tien-Kuen Chung, Chih-Kuang Chen
  • Methods and compositions for treating hyperuricemia and metabolic disorders associated with hyperuricemia
    Patent number: 8865689
    Abstract: Methods and compositions for treating and/or preventing hyperuricemia or metabolic disorders associated with hyperuricemia comprising administering to a patient in need a therapeutically effective amount of diacerein, rhein, or a pharmaceutically acceptable salt, an analog, a prodrug, or an active metabolite thereof.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: October 21, 2014
    Assignee: TWi Biotechnology, Inc.
    Inventors: Mannching Sherry Ku, Chih-Kuang Chen, Wei-Shu Lu, I-Yin Lin
  • Methods of decreasing glycosylated hemoglobin in patients with dyslipidemia
    Patent number: 8846758
    Abstract: Methods for treating abnormal glycosylated hemoglobin (HbA1c) levels in a patient in need thereof, wherein the provided methods comprise administering to a patient in need a therapeutically effective amount of an Interleukin-1? modulator. Also, the invention provides compositions comprising at least one lipid modifying agent and an IL-1? modulator.
    Type: Grant
    Filed: July 19, 2012
    Date of Patent: September 30, 2014
    Assignee: TWi Biotechnology, Inc.
    Inventors: Mannching Sherry Ku, Chih-Kuang Chen, Wei-Shu Lu, Chih-Ming Chen, I-Yin Lin
  • Methods of using diacerein as an adjunctive therapy for diabetes
    Patent number: 8536152
    Abstract: The present invention provides methods of treating type II diabetes using combinations of diacerein or its derivatives with other antidiabetic agents. The methods may also allow improving glycemic control of type II diabetes patients and/or reducing side effects and/or cardiovascular risks of antidiabetic agents.
    Type: Grant
    Filed: April 7, 2011
    Date of Patent: September 17, 2013
    Assignee: TWi Biotechnology, Inc.
    Inventors: Mannching Sherry Ku, Danchen Gao, Wei-Shu Lu, Chih-Ming Chen, I-Yin Lin
  • METHODS OF DECREASING GLYCOSYLATED HEMOGLOBIN IN PATIENTS WITH DYSLIPIDEMIA
    Publication number: 20130022610
    Abstract: Methods for treating abnormal glycosylated hemoglobin (HbA1c) levels in a patient in need thereof, wherein the provided methods comprise administering to a patient in need a therapeutically effective amount of an Interleukin-1? modulator. Also, the invention provides compositions comprising at least one lipid modifying agent and an IL-1? modulator.
    Type: Application
    Filed: July 19, 2012
    Publication date: January 24, 2013
    Inventors: Mannching Sherry Ku, Chih-Kuang Chen, Wei-Shu Lu, Chih-Ming Chen, I-Yin Lin
  • METHODS AND COMPOSITIONS FOR TREATING HYPERURICEMIA AND METABOLIC DISORDERS ASSOCIATED WITH HYPERURICEMIA
    Publication number: 20120232044
    Abstract: Methods and compositions for treating and/or preventing hyperuricemia or metabolic disorders associated with hyperuricemia comprising administering to a patient in need a therapeutically effective amount of diacerein, rhein, or a pharmaceutically acceptable salt, an analog, a prodrug, or an active metabolite thereof.
    Type: Application
    Filed: March 7, 2012
    Publication date: September 13, 2012
    Applicant: TWi Biotechnology, Inc.
    Inventors: Mannching Sherry Ku, Chih-Kuang Chen, Wei-Shu Lu, I-Yin Lin
  • Methods of Using Diacerein as an Adjunctive Therapy for Diabetes
    Publication number: 20110251155
    Abstract: The present invention provides methods of treating type II diabetes using combinations of diacerein or its derivatives with other antidiabetic agents. The methods may also allow improving glycemic control of type II diabetes patients and/or reducing side effects and/or cardiovascular risks of antidiabetic agents.
    Type: Application
    Filed: April 7, 2011
    Publication date: October 13, 2011
    Inventors: Mannching Sherry Ku, Danchen Gao, Wei-Shu Lu, Chih-Ming Chen, I-Yin Lin
  • METHODS FOR DIAGNOSING DIABETES AND DETERMINING EFFECTIVENESS OF TREATMENTS
    Publication number: 20110045522
    Abstract: The invention generally relates to novel methods of measuring the effectiveness of a drug for the treatment of diabetes and methods of diagnosing diabetes. In some embodiments of the invention, IL-1Ra is used as a biomarker to measure the effectiveness of a drug for the treatment of diabetes.
    Type: Application
    Filed: August 20, 2010
    Publication date: February 24, 2011
    Inventors: Danchen Gao, Yen-Lun Huang, Feng-Min Lin, Wei-Shu Lu
  • Pharmaceutical Compositions Containing Diacerein
    Publication number: 20100104651
    Abstract: A once-daily controlled-release formulation of diacerein for treating inflammatory or autoimmune diseases or their complications, with reduced adverse side effects and methods of treating such diseases are disclosed.
    Type: Application
    Filed: October 28, 2009
    Publication date: April 29, 2010
    Inventors: Danchen Gao, Jen-Sen Wu, Wei-Shu Lu, Shouchiung Chen, Pei-Chun Kuo, Chih-Ming Chen