Patents by Inventor Wei Shuo Lo

Wei Shuo Lo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9834561
    Abstract: The present invention provides efficient, economical, and improved methods for synthesizing ibrutinib and intermediates thereof. The invention involves a unique biphasic acylation reaction system which advantageously allows for easy separation of ibrutinib from the reaction mixture without additional extraction and wash steps. The isolated ibrutinib formed using the methods described herein can be useful in the preparation of an amorphous form of ibrutinib. In some embodiments, the isolated ibrutinib produced by the processes described herein is a homogenous solution of ibrutinib and DMSO which may be directly used in the formation of the amorphous polymorph. In some embodiments, the isolated ibrutinib is solid ibrutinib. The solid ibrutinib may also be used in the formation of amorphous ibrutinib.
    Type: Grant
    Filed: October 27, 2016
    Date of Patent: December 5, 2017
    Assignee: SCINOPHARM TAIWAN, LTD.
    Inventors: Tsung-Yu Hsiao, MengFen Ho, HsinChang Tseng, WenShing Tsao, YuanChang Huang, Wei-Shuo Lo
  • Patent number: 9765079
    Abstract: Crystalline forms of pemetrexed diacid are provided (Forms 1 and 2) which are readily produced for either laboratory-scale or industrial scale. Processes for the preparation of Forms 1 and 2 are also provided.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: September 19, 2017
    Assignee: SCINTOPHARM TAIWAN, LTD.
    Inventors: Ying-Tzu Lin, Kuan-Hsun Wang, Wei-Shuo Lo, Wen-Wei Lin, Wan-Yin Cheng
  • Patent number: 9765026
    Abstract: The present invention provides novel crystalline forms of apremilast hemitoluene solvate, apremilast hydrate, and apremilast anhydrate and an amorphous form of apremilast, and processes for the preparation of these forms.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: September 19, 2017
    Assignee: SCINOPHARM TAIWAN, LTD.
    Inventors: Hsiao-ping Fang, Wei-Shuo Lo, Kuan Hsun Wang, Yu-Sheng Lin, Tsung-Cheng Hu, YuanChang Huang
  • Publication number: 20170260186
    Abstract: A process for preparing an amorphous form of idelalisib comprises: (a) forming a first solution of idelalisib in a solvent; (b) adding the first solution obtained in step (a) into water to form a second solution; (c) optionally cooling the second solution obtained in step (b) and; (d) isolating the optionally cooled second solution from step (c) to provide the amorphous form of idelalisib. Mild reaction conditions are used in this process. The amorphous form of idelalisib prepared by this process is stable and does not transfer to other crystalline forms easily. This process is suitable for large scale manufacture of idelalisib at a high yield.
    Type: Application
    Filed: March 1, 2017
    Publication date: September 14, 2017
    Inventors: Tsung-Cheng Hu, Wei-Shuo Lo, Kuan-Hsun Wang, Wan-Yin Cheng
  • Publication number: 20170253597
    Abstract: Crystalline forms of pemetrexed diacid are provided (Forms 1 and 2) which are readily produced for either laboratory-scale or industrial scale. Processes for the preparation of Forms 1 and 2 are also provided.
    Type: Application
    Filed: May 10, 2016
    Publication date: September 7, 2017
    Inventors: Ying-Tzu Lin, Kuan-Hsun Wang, Wei-Shuo Lo, Wen-Wei Lin, Wan-Yin Cheng
  • Publication number: 20170145017
    Abstract: The present invention provides efficient, economical, and improved methods for synthesizing ibrutinib and intermediates thereof. The invention involves a unique biphasic acylation reaction system which advantageously allows for easy separation of ibrutinib from the reaction mixture without additional extraction and wash steps. The isolated ibrutinib formed using the methods described herein can be useful in the preparation of an amorphous form of ibrutinib. In some embodiments, the isolated ibrutinib produced by the processes described herein is a homogenous solution of ibrutinib and DMSO which may be directly used in the formation of the amorphous polymorph. In some embodiments, the isolated ibrutinib is solid ibrutinib. The solid ibrutinib may also be used in the formation of amorphous ibrutinib.
    Type: Application
    Filed: October 27, 2016
    Publication date: May 25, 2017
    Inventors: Tsung-Yu HSIAO, MengFen HO, HsinChang TSENG, WenShing TSAO, YuanChang HUANG, Wei-Shuo LO
  • Publication number: 20170121334
    Abstract: Crystalline forms of pemetrexed diacid are provided (Forms 1 and 2) which are readily produced for either laboratory-scale or industrial scale. Processes for the preparation of Forms 1 and 2 are also provided.
    Type: Application
    Filed: May 10, 2016
    Publication date: May 4, 2017
    Inventors: Ying-Tzu Lin, Kuan-Hsun Wang, Wei-Shuo Lo, Wen-Wei Lin, Wan-Yin Cheng
  • Patent number: 9604990
    Abstract: Crystalline forms of pemetrexed diacid are provided (Forms 1 and 2) which are readily produced for either laboratory-scale or industrial scale. Processes for the preparation of Forms 1 and 2 are also provided.
    Type: Grant
    Filed: October 28, 2015
    Date of Patent: March 28, 2017
    Assignee: SCINOPHARM TAIWAN, LTD.
    Inventors: Ying-Tzu Lin, Kuan-Hsun Wang, Wei-Shuo Lo, Wen-Wei Lin, Wan-Yin Cheng
  • Publication number: 20170057916
    Abstract: The present invention provides novel crystalline forms of apremilast hemitoluene solvate, apremilast hydrate, and apremilast anhydrate and an amorphous form of apremilast, and processes for the preparation of these forms.
    Type: Application
    Filed: August 24, 2016
    Publication date: March 2, 2017
    Inventors: Hsiao-ping FANG, Wei-Shuo LO, Kuan Hsun WANG, Yu-Sheng LIN, Tsung-Cheng HU, YuanChang HUANG
  • Publication number: 20160122355
    Abstract: Crystalline forms of pemetrexed diacid are provided (Forms 1 and 2) which are readily produced for either laboratory-scale or industrial scale. Processes for the preparation of Forms 1 and 2 are also provided.
    Type: Application
    Filed: October 28, 2015
    Publication date: May 5, 2016
    Inventors: Ying-Tzu Lin, Kuan-Hsun Wang, Wei-Shuo Lo, Wen-Wei Lin, Wan-Yin Cheng
  • Patent number: 7479260
    Abstract: A recycling facility includes a receptacle for receiving the ammunition to be cleaned, a gas tank for receiving a pressurized gas and coupled to the receptacle, for supplying the pressurized gas to the receptacle, and a heater coupled between the gas tank and the receptacle, for preheating the pressurized gas before the pressurized gas flowing into the receptacle, and for melting and removing the TNT material from the ammunition. The receptacle includes a control valve coupled between the heater and the receptacle, and a control valve coupled between the heater and the gas tank. A collecting casing may be coupled to the receptacle, and coupled to the gas tank via a filter.
    Type: Grant
    Filed: October 25, 2005
    Date of Patent: January 20, 2009
    Assignee: Taiwan Supercritical Technology Co., Ltd.
    Inventors: Zui Yeh Lin, Tzu Lung Ho, Wei Shuo Lo, Wan Kuei Yao, Yung Ho Chiu, Ching Hsien Liu, Yu Jen Lin