Patents by Inventor Wei-Tai Young

Wei-Tai Young has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190282608
    Abstract: The present invention concerns methods of administering a therapeutically effective dose of a sorbent for an inflammatory mediator to a patient where the inflammatory mediator is one or more of enzymes, cytokines, prostaglandins, eicosanoids, leukotrienes, kinins, complement, coagulation factors, endotoxins, enterotoxins, lipopolysaccharide, cell fragments, bile salts, fatty acids, phospholipids, interferon and immunomodulatory antibodies, biologics or drugs.
    Type: Application
    Filed: May 29, 2019
    Publication date: September 19, 2019
    Inventors: Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
  • Publication number: 20190201867
    Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising either polyol or zwitterionic groups designed to adsorb endotoxins and other inflammatory mediator molecules. The inventions are in the field of porous polymeric sorbents, also in the field of broadly reducing endotoxins in blood and blood products that can cause endotoxemia, additionally, in the field of broadly removing endotoxins by perfusion or hemoperfusion.
    Type: Application
    Filed: May 18, 2017
    Publication date: July 4, 2019
    Inventors: Tamaz GULIASHVILI, Thomas GOLOBISH, Maryann GRUDA, Pamela O'SULLIVAN, Andrew SCHEIRER, Vincent CAPPONI, Phillip CHAN, Wei-Tai YOUNG
  • Patent number: 10314859
    Abstract: Disclosed herein are compositions and methods for preventing or treating acute or chronic oral mucositis, esophagitis, enteritis, colitis, or gastrointestinal acute radiation syndrome (GI-ARS) caused by radiation exposure, using one or more enteron sorbent polymers administered gastrointestinally (e.g. orally, via feeding or gastric tube, via ostomy, or rectally).
    Type: Grant
    Filed: February 2, 2018
    Date of Patent: June 11, 2019
    Assignee: Cytosorbents Corporation
    Inventors: Humayra Begum Ali, Thomas D. Golobish, Vincent J. Capponi, Phillip P. Chan, Wei Tai Young, Andrew Robert Scheirer
  • Publication number: 20180311273
    Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
    Type: Application
    Filed: June 26, 2018
    Publication date: November 1, 2018
    Inventors: Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
  • Publication number: 20180303870
    Abstract: The invention concerns biocompatible polymer systems comprising at least one polymer with a plurality of pores, said polymer comprising a sulfonic acid salt functionality designed to adsorb a broad range of protein based toxins from less than 0.5 kDa to 1,000 kDa and positively charged ions including but not limited to potassium.
    Type: Application
    Filed: October 21, 2016
    Publication date: October 25, 2018
    Inventors: Thomas GOLOBISH, Maryann GRUDA, Tamaz GULIASHVILI, Pamela O'SULLIVAN, Andrew SCHEIRER, Vi DAN, Wei-Tai YOUNG, Vincent CAPPONI, Phillip CHAN
  • Publication number: 20180280602
    Abstract: A size-selective hemocompatible porous polymeric adsorbent system is provided, the polymer system comprises at least one crosslinking agent and at least one dispersing agent, and the polymer has a plurality of pores with diameters in the range from about 17 to about 40,000 Angstroms.
    Type: Application
    Filed: March 28, 2017
    Publication date: October 4, 2018
    Inventors: Wei-Tai Young, Robert Albright, Thomas Golobish, Vincent Capponi
  • Patent number: 10034894
    Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: July 31, 2018
    Assignee: CYTOSORBENTS CORPORATION
    Inventors: Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
  • Publication number: 20180169138
    Abstract: Disclosed herein are compositions and methods for preventing or treating acute or chronic oral mucositis, esophagitis, enteritis, colitis, or gastrointestinal acute radiation syndrome (GI-ARS) caused by radiation exposure, using one or more enteron sorbent polymers administered gastrointestinally (e.g. orally, via feeding or gastric tube, via ostomy, or rectally).
    Type: Application
    Filed: February 2, 2018
    Publication date: June 21, 2018
    Inventors: Humayra Begum Ali, Thomas D. Golobish, Vincent J. Capponi, Phillip P. Chan, Wei Tai Young, Andrew Robert Scheirer
  • Patent number: 9931357
    Abstract: Disclosed herein are compositions and methods for preventing or treating acute or chronic oral mucositis, esophagitis, enteritis, colitis, or gastrointestinal acute radiation syndrome (GI-ARS) caused by radiation exposure, using one or more enteron sorbent polymers administered gastrointestinally (e.g. orally, via feeding or gastric tube, via ostomy, or rectally).
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: April 3, 2018
    Assignee: CytoSorbents Corporation
    Inventors: Humayra Begum Ali, Thomas D. Golobish, Vincent J. Capponi, Phillip P. Chan, Wei-Tai Young, Andrew Robert Scheirer
  • Publication number: 20170296574
    Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
    Type: Application
    Filed: June 28, 2017
    Publication date: October 19, 2017
    Inventors: Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
  • Publication number: 20170216345
    Abstract: Disclosed herein are compositions and methods for preventing or treating acute or chronic oral mucositis, esophagitis, enteritis, colitis, or gastrointestinal acute radiation syndrome (GI-ARS) caused by radiation exposure, using one or more enteron sorbent polymers administered gastrointestinally (e.g. orally, via feeding or gastric tube, via ostomy, or rectally).
    Type: Application
    Filed: October 2, 2015
    Publication date: August 3, 2017
    Applicant: Cytosorbents Corporation
    Inventors: Humayra Begum ALI, Thomas D. GOLOBISH, Vincent J. CAPPONI, Phillip P. CHAN, Wei-Tai YOUNG, Andrew Robert SCHEIRER
  • Patent number: 9717755
    Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
    Type: Grant
    Filed: April 1, 2011
    Date of Patent: August 1, 2017
    Assignee: Cytosorbents Corporation
    Inventors: Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Robert H. Bartlett, Humayra Begum Ali
  • Patent number: 9604196
    Abstract: A size-selective hemocompatible porous polymeric adsorbent system is provided, the polymer system comprises at least one crosslinking agent and at least one dispersing agent, and the polymer has a plurality of pores with diameters in the range from about 17 to about 40,000 Angstroms.
    Type: Grant
    Filed: May 22, 2012
    Date of Patent: March 28, 2017
    Assignee: Cytosorbent, Inc.
    Inventors: Wei-Tai Young, Robert L. Albright, Thomas D. Golobish, Vincent Capponi, Philip Chan
  • Publication number: 20160279163
    Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
    Type: Application
    Filed: June 3, 2016
    Publication date: September 29, 2016
    Inventors: Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Robert H. Bartlett, Humayra Begum Ali
  • Publication number: 20130195792
    Abstract: The present invention concerns methods of treating systemic, regional, or local inflammation from a patient suffering or at risk of inflammation comprising administration of a therapeutically effective dose of a sorbent that sorbs an inflammatory mediator in said patient. In some preferred embodiments, the sorbent is a biocompatible organic polymer.
    Type: Application
    Filed: April 1, 2011
    Publication date: August 1, 2013
    Applicant: CYTOSORBENTS CORPORATION
    Inventors: Phillip P. Chan, Wei-Tai Young, Vincent J. Capponi, Thomas D. Golobish, Robert H. Bartlett
  • Publication number: 20120238441
    Abstract: A size-selective hemocompatible porous polymeric adsorbent system is provided, the polymer system comprises at least one crosslinking agent and at least one dispersing agent, and the polymer has a plurality of pores with diameters in the range from about 17 to about 40,000 Angstroms
    Type: Application
    Filed: May 22, 2012
    Publication date: September 20, 2012
    Inventors: Wei-Tai Young, Robert L. Albright, Thomas D. Golobish, Vincent Capponi, Philip Chan
  • Patent number: 8211310
    Abstract: A size-selective hemocompatible porous polymeric adsorbent system is provided, the polymer system comprises at least one polymer with a plurality of pores, and the polymer has at least one transport pore with a diameter from about 250 Angstroms to about 2000 Angstroms, and the polymer has a transport pore volume greater than about 1.8% to about 78% of a capacity pore of volume of the polymer.
    Type: Grant
    Filed: September 9, 2010
    Date of Patent: July 3, 2012
    Assignee: Cytosorbents, Inc.
    Inventors: Wei-Tai Young, Robert L. Albright, Thomas D. Golobish, Vincent Capponi, Philip Chan
  • Publication number: 20110210074
    Abstract: A polymer sorbent clears myoglobin from blood and/or other physiological fluids and solutions. Normal saline or human serum in which myoglobin was dissolved is perfused by a peristaltic pump through a column packed with the polymer sorbent. After a four-hour perfusion, the myoglobin level in normal saline fell from initial levels to virtually undetectable levels. Perfusion through the polymer sorbent was then found to lower concentrations of dissolved myoglobin to a significant degree in samples of human serum after four hours, indicating that the polymer sorbent is an effective sorbent for myoglobin.
    Type: Application
    Filed: June 26, 2009
    Publication date: September 1, 2011
    Inventors: James F. Winchester, Wei-Tai Young, Vincent J. Capponi
  • Publication number: 20110070424
    Abstract: A size-selective hemocompatible porous polymeric adsorbent system is provided, the polymer system comprises at least one polymer with a plurality of pores, and the polymer has at least one transport pore with a diameter from about 250 Angstroms to about 2000 Angstroms, and the polymer has a transport pore volume greater than about 1.8% to about 78% of a capacity pore of volume of the polymer.
    Type: Application
    Filed: September 9, 2010
    Publication date: March 24, 2011
    Inventors: Wei-Tai Young, Robert L. Albright, Thomas D. Golobish, Vincent Capponi, Phillip Chan
  • Patent number: 7875182
    Abstract: Size-selective hemocompatible porous polymeric adsorbents are provided with a pore structure capable of excluding molecules larger than 50,000 Daltons, but with a pore system that allows good ingress and egress of molecules smaller than 35,000 Daltons. The pore system in these porous polymeric adsorbents is controlled by the method of synthesis so that 98% of the total pore volume is located in pores smaller than 300 Angstroms (?) in diameter with a working pore size range within 100 to 300 ? in diameter. The porous polymeric adsorbents of this invention are very selective for extracting midsize proteins, such as cytokines and ?2-microglobulin, from blood and other physiologic fluids while keeping the components required for good health such as cells, platelets, albumin, hemoglobin, fibrinogen, and other serum proteins intact.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: January 25, 2011
    Assignee: Cytosorbents, Inc.
    Inventors: Wei-Tai Young, Robert L. Albright, Thomas D. Golobish