Abstract: The present invention belongs to the technical field of chemical drugs. Provided are a salt of an endothelin A (ETA) receptor antagonist compound, and a preparation method therefor and the use thereof.

Abstract: This application relates to a roller device. The device comprises: a roller; and a roller axle, the roller axle comprises: an axle portion configured to mount the roller such that the roller is rotatable about the axle portion; and a riveting portion at a mounting end of the roller axle with respect to an axial direction of the roller axle, and extending from the mounting end in a direction away from the axle portion, wherein, when the roller device is pressed against a carrier under force, the riveting portion can pierce the carrier such that the roller axle is riveted with the carrier through the riveting portion.

Abstract: Use of CD83+ mesenchymal stem cells/CD83+ overexpressed mesenchymal stem cells in the preparation of drugs for preventing/treating at least one of autoimmune disease or inflammatory-related disease is provided. The CD83+ mesenchymal stem cells/CD83+ overexpressed mesenchymal stem cells are capable of increasing the secretion of at least one of anti-inflammatory factor or immunosuppressive factor. Immunosuppressive or anti-inflammatory function-prone CD83+ mesenchymal stem cells/CD83+ overexpressed mesenchymal stem cells and a preparation method for immunosuppressive or anti-inflammatory function enhanced CD83+ PD-L1+ mesenchymal stem cells are also provided. The immunosuppressive or anti-inflammatory function enhanced CD83+PD-L1+-MSCs can significantly reduce the mortality rate and inflammatory response of the sepsis in the treatment of sepsis and can also significantly improve the clinical symptom of the arthritis in mice in the treatment of collagen induced arthritis.

Abstract: An emission reduction device for cooking fumes produced from smoking, frying and roasting is provided, which includes a purifying-tank shell. One end of the purifying-tank shell is provided with an air inlet and other end of the purifying-tank shell is provided with an air outlet. The device further includes a nebulizer, an ultrasonic coagulating unit, and an electrostatic deposition unit, which are sequentially arranged in the purifying-tank shell from the air inlet to the air outlet. A box body is connected to the air outlet of the purifying-tank shell, the box body is provided with a photocatalytic oxidation unit, a plasma catalytic oxidation assembly and an end filter unit therein. An exhaust port is installed on a rear side of the box body. Two sides of the ultrasonic coagulating unit are each provided with a flow rectifier which is longitudinally and slidably arranged in the purifying-tank shell.

Abstract: A gas infusion tank for a beverage machine includes a tank body defining a holding space for accommodating beverages. A mixing element includes a mixing chamber, an ascending pipe, and a descending pipe. A top of the ascending pipe is fluidly connected to the mixing chamber and a bottom of the ascending pipe has a liquid inlet. The liquid inlet is fluidly connected to the holding space. A top of the descending pipe is fluidly connected to the mixing chamber and a bottom of the descending pipe includes a liquid outlet in fluid communication with the nozzle. A gas intake hole connects the holding space with the mixing chamber.

Abstract: The present disclosure relates to electrical machines, such as liquid-cooled motors. The liquid-cooled motors can include a stator with cooling tube channels (e.g., corrugated channels) having tubes inserted and expanded. Lamination holes for each lamination in the lamination stack of the stator can have varying diameter along the axial direction to achieve a corrugated internal feature. The tubes for cooling liquid can be fitted in the lamination holes of the stator. In some embodiments, hydraulic expansion expands and plastically deforms the tubes to the contour of the corrugated internal feature of the corrugated channel. In some embodiments, the tube can also be inserted in the corrugated channel and a stator head plate, thereby helping create a compact stator by removing the need for tube connections to connect the corrugated channels.

Abstract: A cable includes: a core wire; a sheath covering the core wire; a shielding layer covering the sheath; and an outer insulating layer covering the shielding layer; wherein the core wire includes a pair of inner core wires and an insulating layer covering the pair of inner core wires by extrusion molding, each of the pair of inner core wires includes an inner conductor and an inner insulating layer covering the inner conductor, and the sheath wraps the insulating layer in a spiral winding way.

Abstract: Disclosed are a compound of formula (I), a preparation method therefor, and a medical application thereof. In particular, provided are the compound of formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof. These compounds are agonists of a glucagon-like peptide-1 receptor (GLP-1R). The present invention also relates to a pharmaceutical composition containing these compounds and use of the compound in a drug for treating diseases such as diabetes.

Abstract: A stator assembly for a rotating electrical machine is operatively associated with an internal cooling circuit including a plurality of cooling channels disposed through a stator core. To directed a liquid coolant medium through the stator core without leakage, the internal cooling circuit is formed from a plurality of cooling tubes including linear tubes and elbow tubes. Linear tubes are disposed in the cooling channels and can be expanded with a hydraulic expansion tool to frictionally fit the linear tube therein. The elbow tubes can fluidly couple two or more linear tubes and are disposed proximately beyond the first and second axial end faces of the stator core. To encapsulate the elbow tubes, first and second stator end castings of thermally conductive, electrically isolating material can be cast adjacent the first and second axial end faces.

Abstract: A gas infusion tank for a beverage machine includes a tank body defining a holding space for accommodating beverages. A mixing element includes a mixing chamber, an ascending pipe, and a descending pipe. A top of the ascending pipe is fluidly connected to the mixing chamber and a bottom of the ascending pipe has a liquid inlet. The liquid inlet is fluidly connected to the holding space. A top of the descending pipe is fluidly connected to the mixing chamber and a bottom of the descending pipe includes a liquid outlet in fluid communication with the nozzle. A gas intake hole connects the holding space with the mixing chamber.

Abstract: This application relates to a roller device. The device comprises: a roller; and a roller axle, the roller axle comprises: an axle portion configured to mount the roller such that the roller is rotatable about the axle portion; and a riveting portion at a mounting end of the roller axle with respect to an axial direction of the roller axle, and extending from the mounting end in a direction away from the axle portion, wherein, when the roller device is pressed against a carrier under force, the riveting portion can pierce the carrier such that the roller axle is riveted with the carrier through the riveting portion.

Abstract: A cable includes: core wires comprising a pair of inner conductors and an inner insulating layer separately covered around each of the pair of inner conductors; a wrapping layer covering the core wires; a shielding layer covering the wrapping layer; and an outer coating layer covering the shielding layer; wherein the wrapping layer comprises a first wrapping layer covering the core wires and a second wrapping layer covering the first wrapping layer.

Abstract: The present disclosure relates to electrical machines, such as liquid-cooled motors. The liquid-cooled motors can include a stator with cooling tube channels (e.g., corrugated channels) having tubes inserted and expanded. Lamination holes for each lamination in the lamination stack of the stator can have varying diameter along the axial direction to achieve a corrugated internal feature. The tubes for cooling liquid can be fitted in the lamination holes of the stator. In some embodiments, hydraulic expansion expands and plastically deforms the tubes to the contour of the corrugated internal feature of the corrugated channel. In some embodiments, the tube can also be inserted in the corrugated channel and a stator head plate, thereby helping create a compact stator by removing the need for tube connections to connect the corrugated channels.

Abstract: A beverage mixing assembly for mixing a gas into a liquid to thereby form a solution includes a mixer body having a first upstream inlet configured to receive the gas, a second upstream inlet configured to receive the liquid, and a downstream outlet configured to dispense the solution from the mixer body. The first upstream inlet defines a first orifice configured to spray the gas into the mixer body and the second upstream inlet defines a second orifice configured to spray the liquid into the mixer body such that the gas collides into the liquid as the liquid conveys from the second upstream inlet to the downstream outlet to thereby mix into the liquid and form the solution.

Abstract: Provided in the present invention is a series of selective Factor XIa (FXIa) inhibitors, relating to the technical field of chemical drugs. The present invention also relates to pharmaceutical compositions containing said compounds and a use of said compounds in drugs for the treatment of diseases such as thromboembolism.

Abstract: An emission reduction device for cooking fumes produced from smoking, frying and roasting is provided, which includes a purifying-tank shell. One end of the purifying-tank shell is provided with an air inlet and other end of the purifying-tank shell is provided with an air outlet. The device further includes a nebulizer, an ultrasonic coagulating unit, and an electrostatic deposition unit, which are sequentially arranged in the purifying-tank shell from the air inlet to the air outlet. A box body is connected to the air outlet of the purifying-tank shell, the box body is provided with a photocatalytic oxidation unit, a plasma catalytic oxidation assembly and an end filter unit therein. An exhaust port is installed on a rear side of the box body. Two sides of the ultrasonic coagulating unit are each provided with a flow rectifier which is longitudinally and slidably arranged in the purifying-tank shell.

Abstract: A sensor system for monitoring a device, the sensor system including a housing, a base configured to attach the sensor system to the device to be monitored, a sensor configured to obtain data related to at least one operating parameter of the device, and an integral energy harvesting device configured to provide at least a portion of the energy required to operate the sensor system.

Abstract: A stator assembly for a rotating electrical machine is operatively associated with an internal cooling circuit including a plurality of cooling channels disposed through a stator core. To directed a liquid coolant medium through the stator core without leakage, the internal cooling circuit is formed from a plurality of cooling tubes including linear tubes and elbow tubes. Linear tubes are disposed in the cooling channels and can be expanded with a hydraulic expansion tool to frictionally fit the linear tube therein. The elbow tubes can fluidly couple two or more linear tubes and are disposed proximately beyond the first and second axial end faces of the stator core. To encapsulate the elbow tubes, first and second stator end castings of thermally conductive, electrically isolating material can be cast adjacent the first and second axial end faces.

Abstract: A beverage mixing assembly for mixing a gas into a liquid to thereby form a solution includes a mixer body having a first upstream inlet configured to receive the gas, a second upstream inlet configured to receive the liquid, and a downstream outlet configured to dispense the solution from the mixer body. The first upstream inlet defines a first orifice configured to spray the gas into the mixer body and the second upstream inlet defines a second orifice configured to spray the liquid into the mixer body such that the gas collides into the liquid as the liquid conveys from the second upstream inlet to the downstream outlet to thereby mix into the liquid and form the solution.

Abstract: The present invention provides a parallel current-sharing device and control method without a current-sharing bus, for implementing parallel current sharing of direct-current outputs of a plurality of power conversion submodules. The parallel current-sharing device comprises a voltage control module and a plurality of power conversion submodules. The voltage control module and the plurality of power conversion submodules having parallel outputs form an outer voltage loop. The power conversion submodules comprise respective inner current loops and sample respective current feedback signals to generate inner current loop control signals, and the inner current loop control signals are superposed with an outer voltage loop control signal to control output of the power conversion submodules. An independent current bus is not required, and only one unidirectional outer control voltage loop is required.