Patents by Inventor Wei-Xing Zong

Wei-Xing Zong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immortalized mouse fibroblast cell lines deficient in Bax and/or Bak
    Patent number: 8389276
    Abstract: The present invention relates to a composition comprising an immortalized cell line which is deficient in the expression of one or more gene(s) of the intrinsic apoptotic pathway, selected from the group consisting of Bax, Bak, and mixtures thereof. The present invention further relates to the product of a process for producing an immortalized mouse fibroblast cell line which is deficient in the expression of Bax, Bak, and mixtures thereof. Finally, the present invention relates to a method and a kit for identifying a compound or composition which induces or blocks the extrinsic apoptotic pathway.
    Type: Grant
    Filed: November 12, 2002
    Date of Patent: March 5, 2013
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Wei-Xing Zong, Craig B. Thompson, Tullia Lindsten
  • Methods of identifying anti-cancer agents and uses thereof
    Patent number: 8304182
    Abstract: The present invention provides methods of identifying and/or detecting anti-cancer agents. The present invention provides methods of identifying and/or detecting compounds that can activate PARP and/or induce necrosis. The present invention also provides for methods of treating cancer in an individual. The present invention also provides kits for identifying and/or detecting anti-cancer agents.
    Type: Grant
    Filed: December 6, 2010
    Date of Patent: November 6, 2012
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Craig B Thompson, Wei-Xing Zong
  • METHODS OF IDENTIFYING ANTI-CANCER AGENTS AND USES THEREOF
    Publication number: 20110130340
    Abstract: The present invention provides methods of identifying and/or detecting anti-cancer agents. The present invention provides methods of identifying and/or detecting compounds that can activate PARP and/or induce necrosis. The present invention also provides for methods of treating cancer in an individual. The present invention also provides kits for identifying and/or detecting anti-cancer agents.
    Type: Application
    Filed: December 6, 2010
    Publication date: June 2, 2011
    Inventors: Craig B. Thompson, Wei-Xing Zong
  • Methods of identifying anti-cancer agents and uses thereof
    Patent number: 7846723
    Abstract: The present invention provides methods of identifying and/or detecting anti-cancer agents. The present invention provides methods of identifying and/or detecting compounds that can activate PARP and/or induce necrosis. The present invention also provides for methods of treating cancer in an individual. The present invention also provides kits for identifying and/or detecting anti-cancer agents.
    Type: Grant
    Filed: September 15, 2008
    Date of Patent: December 7, 2010
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Craig B Thompson, Wei-Xing Zong
  • METHODS OF IDENTIFYING ANTI-CANCER AGENTS AND USES THEREOF
    Publication number: 20090093458
    Abstract: The present invention provides methods of identifying and/or detecting anti-cancer agents. The present invention provides methods of identifying and/or detecting compounds that can activate PARP and/or induce necrosis. The present invention also provides for methods of treating cancer in an individual. The present invention also provides kits for identifying and/or detecting anti-cancer agents.
    Type: Application
    Filed: September 15, 2008
    Publication date: April 9, 2009
    Inventors: Craig B. Thompson, Wei-Xing Zong
  • Method of identifying compounds that induce cell death by necrosis
    Patent number: 7439031
    Abstract: The present invention provides methods of identifying and/or detecting anti-cancer agents. The present invention provides methods of identifying and/or detecting compounds that can activate PARP and/or induce necrosis. The present invention also provides for methods of treating cancer in an individual. The present invention also provides kits for identifying and/or detecting anti-cancer agents.
    Type: Grant
    Filed: December 15, 2004
    Date of Patent: October 21, 2008
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Craig B. Thompson, Wei-Xing Zong
  • Methods of identifying anti-cancer agents and uses thereof
    Publication number: 20050142621
    Abstract: The present invention provides methods of identifying and/or detecting anti-cancer agents. The present invention provides methods of identifying and/or detecting compounds that can activate PARP and/or induce necrosis. The present invention also provides for methods of treating cancer in an individual. The present invention also provides kits for identifying and/or detecting anti-cancer agents.
    Type: Application
    Filed: December 15, 2004
    Publication date: June 30, 2005
    Inventors: Craig Thompson, Wei-Xing Zong
  • Immortalized mouse fibroblast cell lines deficient in bax and /or bak
    Publication number: 20030091982
    Abstract: The present invention relates to a composition comprising an immortalized cell line which is deficient in the expression of one or more gene(s) of the intrinsic apoptotic pathway, selected from the group consisting of Bax, Bak, and mixtures thereof. The present invention further relates to the product of a process for producing an immortalized mouse fibroblast cell line which is deficient in the expression of Bax, Bak, and mixtures thereof. Finally, the present invention relates to a method and a kit for identifying a compound or composition which induces or blocks the extrinsic apoptotic pathway.
    Type: Application
    Filed: November 12, 2002
    Publication date: May 15, 2003
    Inventors: Wei-Xing Zong, Craig B. Thompson, Tullia Lindsten