Abstract: Anti-BCMA antibodies and chimeric antigen receptors (CARs) are provided. Immune cells expressing the anti-BCMA CAR can be used to treat cancer. The anti-BCMA antibodies and CARs can recognize the extracellular domains of human BCMA. The anti-BCMA CAR T cells show specific cytotoxicity towards BCMA-positive target cells.

Abstract: An electrode (100), an electrophysiology catheter (200) and an ablation system are disclosed. The electrode (100) is configured to be disposed at a distal end of a catheter (200) and includes a proximal electrode portion (110), a main electrode portion (120) and a distal electrode portion (130), which are sequentially joined together from a proximal end to a distal end of the electrode. The main electrode portion (120) includes a first section (121) and a second section (122), which are joined to each other along an axis of the catheter (200). At least one of the proximal electrode portion (110) and the distal electrode portion (130) is configured to be movably connected to the catheter (200). The main electrode portion (120) is configured to switch between a contracted configuration and a folded configuration along with relative movement of the proximal electrode portion (110) and the distal electrode portion (130) along the catheter (200).

Abstract: A device for reducing preparation defects of three-dimensional (3D) printing technology by following micro-rolling includes a laser. The laser is connected to an electric telescopic rod through a fastener, a pressing tool is arranged at a right side position of an end of the electric telescopic rod, and a main roller is arranged at the pressing tool; and a liquid pipe bracket is arranged at a left side position of an end of the electric telescopic rod, a cooling liquid pipe distributed obliquely is arranged at the liquid pipe bracket, a liquid outlet of the cooling liquid pipe is located behind the main roller, and a pipe joint of the cooling liquid pipe is connected to an external freezing liquid pipe. According to the present disclosure, the microstructure of a deposited layer can be refined, surface defects can be reduced, and the forming quality and performance can be improved.

Abstract: A lanthanum oxycarbonate catalyst, and a preparation method therefor and an application thereof are provided. The lanthanum oxycarbonate catalyst contains a rod-shaped lanthanum oxycarbonate catalyst and a substantially parallelepiped lanthanum oxycarbonate catalyst. The lanthanum oxycarbonate catalyst can be used for efficiently performing a methane oxidative coupling reaction at a relatively low temperature.

Abstract: A lanthanum dioxide carbonate catalyst, a preparation method and a use thereof are provided. The lanthanum dioxide carbonate catalyst comprises hexagonal crystalline lanthanum dioxide carbonate and hexagonal crystalline lanthanum dioxide carbonate containing a doping element R. The method includes the steps of (1) adding an alkali solution to a solution of lanthanum source, and then performing a solid-liquid separation and a drying to obtain lanthanum hydroxide; (2) contacting a solution of a compound containing the doping element R with lanthanum hydroxide, and then performing a drying; (3) calcining the dried product of step (2) under a carbon-containing atmosphere to obtain a lanthanum dioxide carbonate catalyst.

Abstract: Provided are a speech recognition method, a speech recognition apparatus, a computer readable storage medium, and an electronic device. The method comprises: obtaining a sample speech signal, decoding the sample speech signal, obtaining a decoding result, and extracting a first feature from the decoding result; extracting a target speech segment from the sample speech signal, obtaining a log magnitude spectrum of the target speech segment, and determining a second feature according to the log magnitude spectrum; combining the first feature and the second feature to obtain a third feature; training an untrained classifier by using the third feature so as to obtain a trained classifier; and obtaining a third feature to be recognized of a speech signal to be recognized, so as to determine whether the third feature to be recognized comprises a prepositive word.

Abstract: This application discloses a communication system including a target network, and the target network includes at least a first subnetwork domain. The first subnetwork domain includes a first network node that belongs to a first path and a second network node that belongs to a second path. The first path includes a first channel and a second channel that are connected to the first network node, and the second path includes a third channel and a fourth channel that are connected to the second network node. The first channel and the third channel are protection switching channels for each other, and the second channel and the fourth channel are protection switching channels for each other. The first network node and/or the second network node may determine a transmission path of a service based on a state of a channel.

Abstract: The present invention relates to epitopes containing homocitrulline (Heit) that can be used as targets for cancer immunotherapy. The homocitrullinated T cell epitope has (i) a predicted binding score to MIC class II or class I of <30 using the online IEDB prediction program (http://www.iedb.org/) and (ii) at least 5 consecutive amino acids that form a spiral conformational structure. These modified peptides can be used as vaccines or as targets for T cell receptor (TCR) and adoptive T cell transfer therapies.

Abstract: The present application disclose memory devices, power supply methods, charge pump circuits, and systems. An example memory device includes: a memory cell array including rows of memory cells and a word line coupled to each row of memory cells, and a peripheral circuit coupled with a corresponding row of memory cells via the word line and including a first power supply circuit and a second power supply circuit. The first power supply circuit is configured to start outputting a first voltage to a substrate of a first transistor included in a first word line drive circuit coupled to a first unselected word line at a first time instant. The second power supply circuit is configured to start outputting a second voltage to a terminal of the first transistor at a second time instant. The first time instant is earlier than the second time instant.

Abstract: This application provides modified batch systems and methods using perfusion (e.g., intensified perfusion) for increasing productivity and/or cell density in viral particle production to achieve high viral particle, e.g., AAV yield.

Abstract: A nerve stimulation device for delivering pain management electrical pulses to nerves includes a flexible substrate that is skin-mountable or implantable. An implantable lead includes microelectrodes provided with a coating for improving charge delivery via a porous electrode structure, and/or to reduce infection risk. In one embodiment, a flexible-substrate wearable energy transmitter patch transmits a power signal wirelessly (e.g., via induction coils) through the skin to an implanted flexible-substrate stimulator component that receives the power signal, generates a tonic signal for pain mitigation, and delivers the tonic signal to nerve stimulation points adjacent the electrodes of an implanted lead. In another embodiment, a flexible-substrate stimulator includes a power source and pulse generator, and the tonic signal is transmitted wirelessly through the skin to an implanted lead having electrodes for delivering the pulses to the stimulation points.

Abstract: An array substrate includes a first substrate, a switch layer group, an insulation layer group and a reflective layer. The switch layer group includes switch units and first shading layers, the first shading layers being spaced apart, the first shading layer being disposed on a same layer and of a same material as one layer in the switch unit. The insulating layer group is provided with a plurality of first protrusions on a surface away from the first substrate. The reflective layer is provided with a plurality of second protrusions on a surface away from the first substrate. An orthographic projection of the first protrusion on the first substrate is within an orthographic projection of the second protrusion on the first substrate, and an orthographic projection of the first shading layer on the first substrate is within an orthographic projection of the reflective layer on the first substrate.

Abstract: A display panel includes a driving circuit and a signal line. The signal line includes at least two main signal sub-lines each including a first end and a second end, the first ends of the at least two main signal sub-lines are electrically coupled to each other, and the second ends thereof are electrically coupled to each other. N main signal sub-lines in the at least two main signal sub-lines are directly electrically coupled to the driving circuit. Each of the N main signal sub-lines is a direct-coupled main signal sub-line, and a main signal sub-line in the at least two main signal sub-lines other than the direct-coupled main signal sub-lines is an indirect-coupled main signal sub-line, where N is a positive integer.

Abstract: The present invention relates to the technical field of power generation of power systems, and in particular to a power supply and energy storage system using carbon as a medium. The power supply and energy storage system generates energy by reacting carbon dioxide and air, collects carbon monoxide by providing a pressurizing apparatus and a gas storage apparatus, and sends the collected carbon monoxide back to an energy supply apparatus during power consumption peaks, thereby balancing power deficits of loads and renewable energy power generation, considering the stability, reliability, and economic efficiency of the power supply and energy storage system, and improving energy utilization efficiency.

Abstract: An array substrate includes a first substrate, a switch layer group, an insulation layer group and a reflective layer. The switch layer group includes switch units and first shading layers, the first shading layers being spaced apart, the first shading layer being disposed on a same layer and of a same material as one layer in the switch unit. The insulating layer group is provided with a plurality of first protrusions on a surface away from the first substrate. The reflective layer is provided with a plurality of second protrusions on a surface away from the first substrate. An orthographic projection of the first protrusion on the first substrate is within an orthographic projection of the second protrusion on the first substrate, and an orthographic projection of the first shading layer on the first substrate is within an orthographic projection of the reflective layer on the first substrate.

Abstract: A display panel includes a driving circuit and a signal line. The signal line includes at least two main signal sub-lines each including a first end and a second end, the first ends of the at least two main signal sub-lines are electrically coupled to each other, and the second ends thereof are electrically coupled to each other. N main signal sub-lines in the at least two main signal sub-lines are directly electrically coupled to the driving circuit. Each of the N main signal sub-lines is a direct-coupled main signal sub-line, and a main signal sub-line in the at least two main signal sub-lines other than the direct-coupled main signal sub-lines is an indirect-coupled main signal sub-line which is not directly electrically coupled to the driving circuit but electrically coupled to the driving circuit via the direct-coupled main signal sub-line, where N is a positive integer.

Abstract: An array substrate includes a first substrate, a switch layer group, an insulation layer group and a reflective layer. The switch layer group includes switch units and first shading layers, the first shading layers being spaced apart, the first shading layer being disposed on a same layer and of a same material as one layer in the switch unit. The insulating layer group is provided with a plurality of first protrusions on a surface away from the first substrate. The reflective layer is provided with a plurality of second protrusions on a surface away from the first substrate. An orthrographic projection of the first protrusion on the first substrate is within an orthographic projection of the second protrusion on the first substrate, and an orthographic projection of the first shading layer on the first substrate is within an orthographic projection of the reflective layer on the first substrate.

Abstract: An electrode (100), an electrophysiology catheter (200) and an ablation system are disclosed. The electrode (100) is configured to be disposed at a distal end of a catheter (200) and includes a proximal electrode portion (110), a main electrode portion (120) and a distal electrode portion (130), which are sequentially joined together from a proximal end to a distal end of the electrode. The main electrode portion (120) includes a first section (121) and a second section (122), which are joined to each other along an axis of the catheter (200). At least one of the proximal electrode portion (110) and the distal electrode portion (130) is configured to be movably connected to the catheter (200). The main electrode portion (120) is configured to switch between a contracted configuration and a folded configuration along with relative movement of the proximal electrode portion (110) and the distal electrode portion (130) along the catheter (200).

Abstract: Provided compounds of Formula I and I?, pharmaceutical compositions comprising the compounds, and methods of using the same, in treating, for example, the diseases, disorders, or conditions mediated by the degradation of a protein kinase, such as Hematopoietic progenitor kinase 1 (HPK1).

Abstract: The present disclosure provides compounds of Formula I?, compositions comprising the compound of Formula I?, and methods of using the same, in treating diseases, disorders, or conditions mediated by the inhibition of certain kinases, such as hematopoietic progenitor kinase 1 (HPK1) and/or Fms related receptor tyrosine kinases (FLTs), such as FLT3.