Abstract: A composite solution for enhancing induced disease resistance of lentinan (LNT) to a plant, a preparation method of the composite solution, and a method for enhancing induced disease resistance of LNT to a plant are provided. The composite solution for enhancing induced disease resistance of LNT to a plant includes: an LNT-containing solution and an SPc-containing solution, where SPc is a dendritic macromolecule functionalized by an amino functional group, and has a structural formula shown in formula I, where n=1 to 100. An LNT/SPc complex is produced in the composite solution. SPc spontaneously combines with LNT through hydrogen bonding, such that an agglomerate structure formed by LNT in an aqueous solution is broken and reduced to a nano-scale particle size, and a spherical particle is produced, which can significantly reduce a contact angle of the LNT aqueous solution, and promote the distribution and diffusion of LNT.

Abstract: The present invention belongs to the field of medicinal chemistry and relates to a class of substituted tricyclic compounds as PRMT5 inhibitors and the use thereof. Specifically, the present invention provides a compound represented by formula (A) or an isomer, pharmaceutically acceptable salt, solvate, crystal or prodrug thereof, a preparation method therefor, a pharmaceutical composition containing the compounds, and the use of the compounds or the composition for treating a disease mediated by PRMT5. The compounds of the present invention show significant inhibitory activity on PRMT5.

Abstract: An array includes a support including a plurality of discrete wells, a gel material positioned in each of the plurality of discrete wells, and a quality control tracer grafted to the gel material in each of the plurality of discrete wells. The quality control tracer comprises (a) a cleavable nucleotide sequence comprising a cleavage site and (b) a detectable label; and in some aspects, is a cleavable nucleotide sequence with a detectable label and a non-reactive nucleotide sequence or a primer nucleotide sequence.

Abstract: Systems, methods, and computer-readable media are disclosed for estimating impressions for a digital out of home (DOOH) advertising spaces (e.g., digital billboards and screens). A DOOH advertising system may determine the location of relevant DOOH advertising spaces and the location of certain consumers with known attributes and a known location. Based on this information the DOOH advertising system may estimate a number of impressions for a given DOOH advertising space and a given consumer segment associated with attributes of consumers within a certain distance from the DOOH advertising space. Using this information, the DOOH advertising spaces having the highest estimated impressions for a given consumer segment may be identified.

Abstract: A method for manufacturing a semiconductor device is described. The method includes the following steps. A low-dimensional material (LDM) layer is formed on a semiconductor substrate, wherein the LDM layer includes sublayers stacked upon one another. A plasma treatment is performed to the LDM layer to transform at least one sublayer into an oxide layer, wherein the plasma treatment is performed under a temperature equivalent to or lower than about 80 degrees Celsius. At least one electrode is disposed over the oxide layer.

Abstract: A semiconductor device is provided. The semiconductor device includes a substrate having a surface. The semiconductor device includes a conductive pad over a portion of the surface. The conductive pad has a curved top surface, and a width of the conductive pad increases toward the substrate. The semiconductor device includes a device over the conductive pad. The semiconductor device includes a solder layer between the device and the conductive pad. The solder layer covers the curved top surface of the conductive pad, and the conductive pad extends into the solder layer.

Abstract: A method for selecting an application and associated operational guidance to utilize on a mobile device is disclosed. In one embodiment, such a method identifies a selected environment of interest. Within the selected environment, the method identifies one or more applications that are commonly utilized by users within the selected environment and documents the one or more applications. The method detects physical entry of a particular user into the selected environment and, in response to detecting the entry, automatically notifies the particular user of the one or more applications that are commonly utilized within the selected environment. In certain embodiments, the method enables the user to quickly launch the one or more applications and/or provides operational guidance to the user with regard to using the one or more applications. A corresponding system and computer program product are also disclosed.

Abstract: The present invention relates to a reagent container and an operation method therefor, and a reagent treatment system.

Abstract: The present invention provides a device, kit and method for extracting and testing nucleic acids. The devices comprises: a first container (101), a second container (102), and an air storage device (103), wherein the first container (101) is used for accommodating or containing a reagent for extracting nucleic acids; a first valve (107) is provided between the first container (101) and the second container (102); the second container (102) and the gas storage device (103) are in fluid communication; the second container (102) has a sample inlet (104) and a sample outlet (105), and the sample inlet (104) is provided with a fourth valve (109); the sample outlet device, a waste liquid pool, a collecting pool and the like.

Abstract: Systems and methods for pessimistic offline reinforcement learning are described herein. In one example, a method for performing offline reinforcement learning determines when sampled states are out of distribution, assigns high probability weights to the sampled states that are out of distribution, generates a fitted Q-function by solving an optimization problem with a minimization term and a maximization term, estimates a Q-value using the fitted Q-function by estimating the overall expected reward assuming the agent is in the present state and performs a present action, and updates the policy according to an existing reinforcement learning algorithm. The minimization term penalizes an overall expected reward when a present state is out of distribution. The maximization term cancels the minimization term when the present state is an in-distribution state.

Abstract: A compound as represented by formula I-1, or a pharmaceutically acceptable salt, a stereoisomer, or a solvate thereof are effective in reducing ALT, AST and ALP as well as helpful in treating hepatic pathological injuries (e.g. hepatocyte steatosis). The compound has wide application prospects in the preparation of a drug for preventing and/or treating liver diseases such as fatty liver, hepatic fibrosis and liver cirrhosis.

Abstract: The disclosure, in some aspects, relates to nucleic acids, compositions and kits useful for gene therapy with reduced immune response to transgene products.

Abstract: An integrated equipment and treatment method for synchronous ecological treatment of domestic sewage and sludge, the equipment includes a one-piece box-shaped main body divided into several tank compartments which includes an anaerobic tank, a sludge reduction and denitrification tank, an aerobic tank, a sedimentation tank, and a disinfection tank, an inlet pipe for sewage and sludge entrance and an outlet pipe for exit of effluent after treatment. The sludge reduction and denitrification tank is equipped with variable microporous aeration pipes, worm fillers and multi-functional water quality online detectors. The aerobic tank is equipped with aeration pipeline components and DO online detectors. The sewage and sludge are guided to passing through the different tank compartments in order for simultaneous sewage treatment and sludge reduction. The removal rate of total nitrogen is as high as 85%, and the simultaneous reduction effect of sludge can reach more than 60%.

Abstract: The disclosure, in some aspects, relates to nucleic acids, compositions and kits useful for gene therapy with reduced immune response to transgene products.

Abstract: The present disclosure provides a compound represented by formula (I), or a salt or a stereoisomer thereof. The compound is capable of effectively inhibiting germination of Clostridium difficile spores with a significant bacteriostatic activity. The compound has an excellent prospect for use in preparation of a drug for preventing and/or treating a C. difficile-caused infectious disease, recurrence of the C. difficile-caused infectious disease, or a complication of the C. difficile-caused infectious disease.

Abstract: The disclosure, in some aspects, relates to nucleic acids, compositions and kits useful for gene therapy with reduced immune response to transgene products.

Abstract: A mounting base structure used for a photographic lamp or monitor comprises a first connecting rod having an end rotatably connected with one side of a photographic lamp or monitor and an end provided with a connecting part. A second connecting rod to be attached to the first connecting rod is hinged to the connecting part. A first threaded hole to be connected with a connecting bolt on a digital video camera is horizontally formed in the side face of the other end of the second connecting rod. The mounting base structure used for the photographic lamp or monitor is simple and compact and facilitates the connection of the photographic lamp or monitor with the digital video camera.

Abstract: A vehicle evaluation method and equipment, the vehicle evaluation method comprises: obtaining current vehicle data of a target vehicle, wherein the current vehicle data includes a vehicle identification; obtaining historical vehicle data of the target vehicle according to the vehicle identification; determining an authenticity of the current vehicle data according to the historical vehicle data; and evaluating the target vehicle according to a determination of the authenticity, and generating an evaluation report of the target vehicle. In the present solution, a detection and an evaluation of the vehicle can be implemented more comprehensively, and an accuracy of vehicle evaluation can be improved.

Abstract: A mounting base structure used for a photographic lamp or monitor comprises a first connecting rod having an end rotatably connected with one side of a photographic lamp or monitor and an end provided with a connecting part. A second connecting rod to be attached to the first connecting rod is hinged to the connecting part. A first threaded hole to be connected with a connecting bolt on a digital video camera is horizontally formed in the side face of the other end of the second connecting rod. The mounting base structure used for the photographic lamp or monitor is simple and compact and facilitates the connection of the photographic lamp or monitor with the digital video camera.

Abstract: Described herein are methods for the surface deposition of polyionic species on a substrate surface. This deposition process can be triggered facilely by oxidizing organometallic species present on the surface of the substrate. This approach is quite general, affording quantitative deposition of polyionic species with a wide range of chemical identities (e.g., synthetic polymers, peptides and DNA) and molecular weights. This approach is in addition suitable for surface deposition of several types of functional materials, including proteins (antibodies), nanomaterials, colloids, lipid vesicles, among others.