Abstract: The present invention concerns the use of compounds and compositions for the treatment or prevention of Flavivirus infections, such as dengue virus infections and Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as dengue virus and Zika virus infection, by administering a compound or composition of the invention, to a subject in need thereof; methods for inhibiting Flavivirus infections, such as dengue virus and Zika virus infections, in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits useful for treating or preventing Flavivirus infections, such as dengue virus and Zika virus infections.

Abstract: Method embodiments are disclosed for treating retinal degeneration in a subject in need thereof. In some embodiments, the method comprises administering to the subject a therapeutically effective amount of compound, and/or a pharmaceutically acceptable salt, prodrug, solvate, hydrate, or tautomer thereof, selected from 3-(dibutylamino)-1-(1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl)propan-1-ol hydrochloride or a compound having a structure according to a formula selected from Formula I, II, or III, as described herein. In some non-limiting examples, the subject has retinitis pigmentosa, LCA, Stargardt’s macular dystrophy, cone-rod dystrophy, choroideremia or age-related macular degeneration.

Abstract: Disclosed are compounds of formula (I) and formula (II): wherein R1, R2, A, and B are as defined herein. Also disclosed is a method of blocking transmission of a Plasmodium parasite and a method of treating or preventing malaria comprising administering to an animal an effective amount of a first compound of formula (I) or (II) either alone or in combination with a second compound selected from elesclomol, NSC174938, NVP-AUY922, Maduramicin, Narasin, Alvespimycin, Omacetaxine, Thiram, Zinc pyrithione, Phanquinone, Bortezomib, Salinomycin sodium, Monensin sodium, Dipyrithione, Dicyclopentamethylene-thiuram disulfide, YM155, Withaferin A, Adriamycin, Romidepsin, AZD-1152-HQPA, CAY10581, Plicamycin, CUDC-101, Auranofin, Trametinib, GSK-458, Afatinib, and Panobinostat.

Abstract: Disclosed are a class of BTK kinase inhibitor compounds with a high activity and a high selectivity and the use thereof in the preparation of a drug for treating BTK target-related diseases. Specifically, disclosed are a compound shown as formula (I), and an isomer and a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure discloses a steel strip coiling temperature control method, a steel strip coiling temperature control device and a steel strip processing system, which relate to the technical field of steel strip production. The method comprises: seeking a corresponding speed compensation coefficient according to a target thickness of the steel strip and a target temperature parameter; seeking a corresponding speed gain coefficient from a second correspondence table according to a steel strip speed; correcting the steel strip speed based on the speed compensation coefficient and the speed gain coefficient to obtain a corrected steel strip speed; and adjusting a cooling efficiency of a laminar flow cooling apparatus according to the corrected steel strip speed.

Abstract: An ultra-high expansion downhole packer includes an anchor, a primary expansion cone, and a central tube. The anchor is provided with a first tapered through-hole having a large end sleeved at a small end of the primary expansion cone. The anchor is radially expandable to anchor with an inner wall of a wellbore. The primary expansion cone is provided with a second tapered through-hole, and the second tapered through-hole has a large end sleeved at a small end of the central tube. The primary expansion cone is a radially expandable structure, and the primary expansion cone supports the anchor after an expansion. The primary expansion cone is provided between the anchor and the central tube. The primary expansion cone is first driven into the anchor to make the anchor radially expand, and then the central tube is driven into the primary expansion cone to make the anchor radially expand again.

Abstract: This invention relates to conjugates of camptothecin analogs with a cell-binding molecule of formula (I), wherein R1, R2, R3, R4, R5, X, L, n, m, T and ----- are defined herein. It also provides methods of making the conjugates of camptothecin analogs to a cell-binding agent, as well as methods of using the conjugates in targeted treatment of cancer, infection, and immunological disorders.

Abstract: A screen projection processing method includes obtaining an operation for a first electronic device, responding to the operation by calling a task manager of the first electronic device to display a plurality of application objects managed by the task manager in a display area of the first electronic device, determining a first application object from the plurality of application objects, and projecting a first display content generated by an application program corresponding to the first application object in an operative state to a second display area of a second electronic device in real-time.

Abstract: A serverless system includes a message management apparatus. The message management apparatus may receive a first message, where the first message is used to indicate to schedule a first stateful function to operate a first state instance; store the first message in a first message queue corresponding to the first state instance, where the first message queue is further used to store a plurality of messages, and each of the plurality of messages is used to indicate one stateful function to operate the first state instance; and transfer a second message to a second stateful function corresponding to the second message, and run the second stateful function corresponding to the second message to operate the first state instance that is in an idle state, where the second message is a message located at a foremost end of the first message queue.

Abstract: A method for preparing a probiotic preparation based on a W1/O/W2 double emulsion structure includes steps of: using a solution containing probiotics or a mixed solution of probiotics and a probiotic protective agent as an internal water phase W1; dissolving an emulsifier in a lipid phase O, and mixing the lipid phase O with the internal water phase W1; then preparing a primary emulsion W1/O by stirring and low-energy emulsification or high-energy emulsification; and using an emulsifier-contained solution as an external water phase W2, and adding the external water phase W2 to the primary emulsion W1/O; then preparing a W1/O/W2 double emulsion by stirring and the low-energy emulsification or the high-energy emulsification, thereby obtaining the probiotic preparation. The double emulsion system is used to embed the probiotics, which can keep the probiotics active during low-temperature storage and freezing and thawing.

Abstract: Disclosed is a human IL-4R antibody or an antigen binding fragment thereof. The antibody or the antigen binding fragment thereof specifically binds with human IL-4R? and binds with a specific epitope in human IL-4R?. Moreover, also provided in the present disclosure are uses of the epitope in screening a human IL-4R binding agent or blocking agent for a human IL-4/IL-13 signal transduction pathway or uses in assessing the efficacy of the binding agent or blocking agent by using the specific epitope.

Abstract: The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to treat subjects with Sjögren's syndrome, or diffuse intrinsic pontine glioma (DIPG).

Abstract: Embodiments are presented herein of apparatuses, systems, and methods for a vehicle-to-everything (V2X) capable wireless device configured to perform sidelink cellular communications. The wireless device performs sidelink communications using a two-stage sidelink control information (SCI) protocol including Stage 1 SCI messaging carried on a physical sidelink control channel (PSCCH), and Stage 2 SCI messaging carried on a physical sidelink shared channel (PSSCH). The SCI messaging may be encoded using polar codes. Channel interleaving is utilized on the SCI to interleave the SCI between two or more layers of a MIMO transmission system. Scrambling for Stage 2 SCI messaging is performed based on the result of a cyclic redundancy check (CRC) performed on Stage 1 SCI messaging. Collisions between sidelink HARQ feedback to be transmitted to a base station and other transmissions are avoided based on a priority analysis of the sidelink HARQ feedback.

Abstract: An image processing method and an image processing apparatus are provided. In the method, first encoding is performed on an input image, to output a first noisy image. De-noising is performed on the first noisy image, to output a first de-noised image. De-noising is performed on the input image according to the first de-noised image, to output a first image.

Abstract: The present application discloses a cerebral perfusion state classification apparatus and method, a device, and a storage medium. The method includes: acquiring, by a transceiving module, cervical blood flow data from an ultrasound data collecting device; determining, by a processor, cerebral perfusion data corresponding to the cervical blood flow data based on the cervical blood flow data and a mapping relationship between the cervical blood flow data and the cerebral perfusion data, and classifying cerebral perfusion states of a plurality of brain regions based on blood perfusion characteristics of the plurality of brain regions in the cerebral perfusion data.

Abstract: The invention relates to a photo-curable liquid resin composition for 3D printing, its preparation process and use, and also to a method of forming a 3D-printed object by using the composition. By using the inventive composition for 3D printing, the improvement of the flexibility and elasticity of the cured composition can be achieved.

Abstract: The present disclosure provides a method for preparing an LED display module, including following steps: step S10: machining a first enclosure around a front surface of a lamp panel; step S30: filling the accommodating pool with glue, and performing a vacuum defoaming treatment on the lamp panel filled with the glue; step S40: performing a first curing treatment on the defoamed lamp panel; step S50: placing the lamp panel with the first enclosure removed in an accommodating appliance, enabling the front surface of the lamp panel with the first enclosure removed to face the bottom of the accommodating appliance, and immersing lamp beads on the lamp panel with the first enclosure removed into defoaming glue in the accommodating appliance; and step S60: applying an acting force, which faces the bottom of the accommodating appliance, to a back surface of the lamp panel with the first enclosure removed.

Abstract: The present disclosure discloses a cerebral perfusion state classification apparatus, method and device, and a model training apparatus. In the apparatus, a transceiver module is used for receiving physiological feature data from different data collection devices; and a processor is used for extracting physiological features from the physiological feature data; inputting the physiological features into a random forest model to cause a plurality of decision-making trees in the random forest model to predict a cerebral perfusion state type corresponding to the physiological features; and classifying a cerebral perfusion state based on the cerebral perfusion state type corresponding to the physiological features.