Patents by Inventor Wei-Bo Wang

Wei-Bo Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Farnesyltransferase inhibitors
    Patent number: 7323570
    Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
    Type: Grant
    Filed: July 25, 2006
    Date of Patent: January 29, 2008
    Assignee: Abbott Laboratories
    Inventors: Akiyo K. Claiborne, Stephen L. Gwaltney, II, Lisa A. Hasvold, Qun Li, Tongmei Li, Nan-Horng Lin, Robert A. Mantei, Todd W. Rockway, Hing L. Sham, Gerard M. Sullivan, Yunsong Tong, Gary Wang, Le Wang, Xilu Wang, Wei-Bo Wang
  • Farnesyltransferase inhibitors
    Patent number: 7211595
    Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
    Type: Grant
    Filed: November 30, 2001
    Date of Patent: May 1, 2007
    Assignee: Abbott Laboratories
    Inventors: Akiyo K. Claiborne, Stephen L. Gwaltney, II, Lisa A. Hasvold, Qun Li, Tongmei Li, Nan-Horng Lin, Robert A. Mantei, Todd W. Rockway, Hing L. Sham, Gerard M. Sullivan, Yunsong Tong, Gary Wang, Le Wang, Xilu Wang, Wei-Bo Wang
  • Farnesyltransferase Inhibitors
    Publication number: 20060264476
    Abstract: Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
    Type: Application
    Filed: July 25, 2006
    Publication date: November 23, 2006
    Inventors: Akiyo Claiborne, Stephen Gwaltney, Lisa Hasvold, Qun Li, Tongmei Li, Nan-Horng Lin, Robert Mantei, Todd Rockway, Hing Sham, Gerard Sullivan, Yunsong Tong, Gary Wang, Le Wang, Xilu Wang, Wei-Bo Wang
  • Farnesyltransferase inhibitors
    Publication number: 20030087940
    Abstract: Substituted imidazoles and thiazoles having the formula 1
    Type: Application
    Filed: November 30, 2001
    Publication date: May 8, 2003
    Inventors: Akiyo K. Claiborne, Stephen L. Gwaltney, Lisa A. Hasvold, Qun Li, Tongmei Li, Nan-Horng Lin, Robert A. Mantei, Todd W. Rockway, Hing L. Sham, Gerard M. Sullivan, Yunsong Tong, Gary Wang, Le Wang, Xilu Wang, Wei-Bo Wang
  • Farnesyltransferase inhibitors
    Publication number: 20020115640
    Abstract: Substituted imidazoles and thiazoles having the formula 1
    Type: Application
    Filed: July 25, 2001
    Publication date: August 22, 2002
    Inventors: Akiyo K. Claiborne, Stephen L. Gwaltney,, Lisa A. Hasvold, Qun Li, Tongmei Li, Nan-Horng Lin, Robert A. Mantei, Todd W. Rockway, Hing L. Sham, Gerard M. Sullivan, Yunsong Tong, Gary Wang, Le Wang, Xilu Wang, Wei-Bo Wang
  • Substituted phenyl farnesyltransferase inhibitors
    Publication number: 20020019527
    Abstract: Compounds of formula (I) 1
    Type: Application
    Filed: April 25, 2001
    Publication date: February 14, 2002
    Inventors: Wei-Bo Wang, Michael L. Curtin, Stephen A. Fakhoury, Stephen L. Gwaltney, Lisa A. Hasvold, Charles W. Hutchins, Qun Li, Nan-Horng Lin, Lissa Taka Jennings Nelson, Steve O'Connor, Hing L. Sham, Gerard M. Sullivan, Gary T. Wang, Xilu Wang
  • Process for preparation of chiral 3-amino-pyrrolidine and analogous bicyclic compounds
    Patent number: 5837868
    Abstract: A process for the preparation of chiral 3-aminopyrrolidine and analogous bicyclic derivatives from dihydroxy olefins by treatment with titanium isopropoxide, an optically active tartrate ester and tert-butyl hydroperoxide, followed by subsequent alkylation of the intermediate with an alkyl or alkenyl magnesium halide, then pyrrolidine ring formation by condensation with an arylmethylamine, subsequent chiral replacement of a ring hydroxyl group with an amino group with further protection thereof, optional additional substitution closing of the second ring, and hydrogenolysis to remove a ring-nitrogen protecting group.
    Type: Grant
    Filed: November 19, 1997
    Date of Patent: November 17, 1998
    Assignee: Abbott Laboratories
    Inventors: Wei-Bo Wang, Qun Li, Daniel T. Chu, Lisa Anne Hasvold
  • Quinolizinone type compounds
    Patent number: 5726182
    Abstract: Antibacterial compounds having the formula ##STR1## and the pharmaceutically acceptable salts, esters and amides thereof, selected preferred examples of which include those compounds whereinA is .dbd.CR.sup.6 --;R.sup.1 is cycloalkyl of from three to eight carbon atoms or substituted phenyl;R.sup.2 is selected from the group consisting of ##STR2## R.sup.3 is halogen; R.sup.4 is hydrogen, loweralkyl, a pharmaceutically acceptable cation, or a prodrug ester group;R.sup.5 is hydrogen, loweralkyl, halo(loweralkyl), or --NR.sup.13 R.sup.14 ; andR.sup.6 is halogen, loweralkyl, halo(loweralkyl), hydroxy-substituted loweralkyl, loweralkoxy(loweralkyl), loweralkoxy, or amino(loweralkyl),as well as pharmaceutical compositions containing such compounds and the use of the same in the treatment of bacterial infections.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 10, 1998
    Assignee: Abbott Laboratories
    Inventors: Daniel T. Chu, Qun Li, Curt S. Cooper, Anthony K. L. Fung, Cheuk M. Lee, Jacob J. Plattner, Zhenkun Ma, Wei-Bo Wang
  • Process for preparation of chiral 3-amino-pyrrolidine and analogous bicyclic compounds
    Patent number: 5703244
    Abstract: A process for the preparation of chiral 3-aminopyrrolidine and analogous bicyclic derivatives from dihydroxy olefins by treatment with titanium isopropoxide, an optically active tartrate ester and tert-butyl hydroperoxide, followed by subsequent alkylation of the intermediate with an alkyl or alkenyl magnesium halide, then pyrrolidine ring formation by condensation with an arylmethylamine, subsequent chiral replacement of a ring hydroxyl group with an amino group with further protection thereof, optional additional substitution closing of the second ring, and hydrogenolysis to remove a ring-nitrogen protecting group.
    Type: Grant
    Filed: November 21, 1996
    Date of Patent: December 30, 1997
    Assignee: Abbott Laboratories
    Inventors: Qun Li, Wei-Bo Wang, Daniel T. Chu, Lisa Anne Hasvold
  • Process for preparation of 4H-4-oxo-quinolizine-3-carboxylic acid
    Patent number: 5693813
    Abstract: A process for the preparation of a compound having the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are defined, from an enamine by chain expansion and ring closure followed by additional derivatization, treatment with a 3-alkoxyl-acryloyl compound, another ring closure, and converting a hydroxyl group to a leaving group.
    Type: Grant
    Filed: February 26, 1997
    Date of Patent: December 2, 1997
    Assignee: Abbott Laboratories
    Inventors: Wei-Bo Wang, Francis A. J. Kerdesky, Chi-Nung W. Hsiao, Qun Li, Daniel T. Chu
  • Quinolizinone type compounds
    Patent number: 5599816
    Abstract: Antibacterial compounds having the formula ##STR1## and the pharmaceutically acceptable salts, esters and amides thereof, selected preferred examples of which include those compounds whereinA is.dbd.CR.sup.6 --;R.sup.1 is cycloalkyl of from three to eight carbon atoms or substituted phenyl;R.sup.2 is selected from the group consisting of ##STR2## R.sup.3 is halogen; R.sup.4 is hydrogen, loweralkyl, a pharmaceutically acceptable cation, or a prodrug ester group;R.sup.5 is hydrogen, loweralkyl, halo(loweralkyl), or --NR.sup.13 R.sup.14 ; andR.sup.6 is halogen, loweralkyl, halo(loweralkyl), hydroxy-substituted loweralkyl, loweralkoxy(loweralkyl), loweralkoxy, or amino(loweralkyl),as well as pharmaceutical compositions containing such compounds and the use of the same in the treatment of bacterial infections.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 4, 1997
    Assignee: Abbott Laboratories
    Inventors: Daniel T. Chu, Qun Li, Curt S. Cooper, Anthony K. L. Fung, Cheuk M. Lee, Jacob J. Plattner, Zhenkun Ma, Wei-Bo Wang