Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.

Abstract: The disclosure discloses a method and device for establishing a bearer. The method includes: determining that a bearer is to be newly established during a switching process of a terminal; and sending a switching request message to a target base station to which the terminal is to be switched, moreover the switching request message carries the bearer to be newly established, and the switching request message is used for enabling the target base station to establish all bearers designated during the switching request message for the terminal.

Abstract: A device and method for measuring the thickness and position tolerance of a wheel bolt hole. The device includes a screw, a handle, a detection pillar and a base plate, where the handle and the base plate are fixed via the screw; the detection pillar is fixed onto the base plate through interference fit; and the detection pillar a bolt hole. The position tolerance and thickness of a bolt hole are measured simultaneously, and the labor intensity is reduced, and the existing bolt hole position tolerance detection tool can be modified for the use as the tool of the device, saving costs. The tool can detect the thickness of a bolt hole and qualitatively determine the range where the difference between the value of bolt hole thickness and the standard value approximately lies, and can be used for the grading of bolt hole thickness values based.

Abstract: A lactone hydrolase having improved activity towards ?-zearalenol is disclosed. The lactone hydrolase has a modified amino acid sequence of SEQ ID NO: 5, wherein the modification is a substitution of valine at position 167 with histidine. A method of degrading ?-zearalenol using such lactone hydrolase is also disclosed.

Abstract: The present invention discloses a wheel mold spraying device, which is composed of a frame, a servo motor, a servo electric cylinder, a hollow shaft, a nozzle and the like. Four side molds of a wheel are respectively placed on four slide plates; hand wheels are rotated to adjust the slide plates to proper positions through lead screws and guide rails; the servo motor drives the rotation of the hollow shaft and the nozzle through belt wheels and a synchronous belt, and the nozzle is automatically opened; and through guide posts, the servo electric cylinder lifts the nozzle to the top end while rotating, in which case the process of spraying for the four side molds can be completed.

Abstract: According to the method provided by some embodiments of the present disclosure, under different gray-scale voltages, the liquid crystal deflection directions of liquid crystal molecules are different, such that when a first frame is displayed, the deflection difference between the deflection direction of the liquid crystal molecules in the pixel structure in the liquid crystal display screen and the deflection direction when a second frame is displayed is increased, after human eyes view the displayed first frame and second frame, an image obtained after the first frame and the second frame are displayed may be observed at different viewing angles, and at this time, the viewing angle of the liquid crystal display screen is increased on the premise of not increasing the number of sub-domains in the pixel structure of the liquid crystal display screen.

Abstract: The present invention discloses a wheel machining technology in which blank quantity is furthest removed by using a 90-degree external turning tool. Under the premise that the rotation direction of a wheel is unchanged, an upper trench of a groove is processed by using a left-handed special cutting-off cutter. Under the premise that the rotation direction of the wheel is unchanged, a lower trench of the groove is processed by using a right-handed special cutting-off cutter. The left-handed special cutter and the right-handed special cutter are added to the wheel machining technology disclosed by the present invention, so as to complete the processing of a groove of an outer wheel rim; a processing program can be pre-edited, so that processed effects conform to the design requirements of drawings of products.

Abstract: The present invention provides a device and method for measuring dimensions of a back boring cutter. The device is formed by a measuring portion (1), a connecting portion (2) and a clamping portion (6). The measuring portion (1) has a first horizontal through hole (7), a horizontal hole (5) and a vertical hole (4). The clamping portion (6) comprises a second horizontal through hole (7?), a side wall of the second horizontal through hole (7?) is provided with a bolt hole (8), and a bolt (3) passes through the bolt hole (8) to install and fix a to-be-measured back boring cutter. One end of the connecting portion (2) is fixed on the measuring portion (1), while the other end is fixed on the clamping portion (6). The device and the method of the present invention have the advantages that simple measurement of important dimensions of the back boring cutter is realized, and dimension detection of the back boring cutter is simpler and more accurate.

Abstract: According to the method provided by some embodiments of the present disclosure, under different gray-scale voltages, the liquid crystal deflection directions of liquid crystal molecules are different, such that when a first frame is displayed, the deflection difference between the deflection direction of the liquid crystal molecules in the pixel structure in the liquid crystal display screen and the deflection direction when a second frame is displayed is increased, after human eyes view the displayed first frame and second frame, an image obtained after the first frame and the second frame are displayed may be observed at different viewing angles, and at this time, the viewing angle of the liquid crystal display screen is increased on the premise of not increasing the number of sub-domains in the pixel structure of the liquid crystal display screen.

Abstract: The present invention provides a wheel spraying device, comprising a frame, an electric motor, a hollow shaft, a ring flange, and cylinders. During use of the device, the need of jacking up and rotating a wheel in wheel spraying can be met, and the difficulty of removing the protection plugs of bolt hole due to thickening and clogging after completion of spraying can be completely avoided. Meanwhile, the device has the characteristics of simple structure, convenience for use, low manufacturing cost, and safe and stable performance.

Abstract: Provided is Compound (I) or a pharmaceutically acceptable salt thereof, which is an inhibitor of TrkA kinase and is useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation and inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis, pelvic pain syndrome, diseases related to an imbalance of the regulation of bone remodeling, and diseases resulting from Connective Tissue Growth Factor aberrant signaling.

Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro -3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.

Abstract: The present disclosure provides a backlight driving method and device and a display device, wherein the backlight includes a plurality of backlight scanning areas, each luminous body corresponding to each backlight scanning area is driven independently, including: acquiring display gray scale of a current frame of image and that of a previous frame of image in a backlight scanning area; determining a first backlight duty ratio according to the display gray scale of the current frame and that of the previous frame; if black frame insertion time in the first backlight duty ratio is smaller than a first black frame insertion time, acquiring a second backlight duty ratio, wherein black frame insertion time in the second backlight duty ratio is not less than the first black frame insertion time; determining drive timing of the luminous bodies in the current frame according to the second backlight duty ratio.

Abstract: The present invention relates to processes for preparing 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, processes for preparing crystallized 6-(4-bromo-2-fluorophenylamino)-7-fluoro-3-methyl-3H-benzoimidazole-5-carboxylic acid (2-hydroxyethyoxy)-amide, and intermediates useful therefore. Also provided herein are pharmaceutical compositions comprising this crystallized compound.

Abstract: The present invention discloses a special wheel spray support, which is composed of a base body, a bottom plate, struts, adjusting blocks, supporting pins, protective jackets, a stop pin and the like. When in use, the special wheel spray support of the present invention can meet the requirements for online spraying of special wheels and bolt hole protection, and is not only high in universality and simple in structure, but also has a series of prominent advantages, such as good safety and reliability, low manufacturing cost, etc.

Abstract: The present invention relates to an improved on-line deburring device of a wheel valve hole, having a frame, electric cylinders, an air cylinder, grinding heads, a motor, guide rails and a transmission shaft. In use, the present invention can meet the requirements for deburring the wheel valve hole; meanwhile, the device has the characteristics of high production efficiency, advanced technique, high automation degree, stable performance, etc.

Abstract: The present invention discloses an on-line wheel cleaning device, having a frame, a cylinder, a motor, a brush chassis, radial brushes, a spline shaft and a spline housing, wherein a sensor enables a wheel to be primarily positioned; a clamping cylinder enables two left clamping rollers and right clamping rollers to clamp the wheel by way of gears, left racks, right racks and a guide rail; a jacking cylinder is used for jacking the brush chassis and the radial brushes through the spline shaft and enabling the brush chassis and the radial brushes to touch a flange plate and a center hole of the wheel, respectively; the motor drives a belt pulley I, the spline housing and the spline shaft to rotate through a synchronous belt and a belt pulley I; an adjusting cylinder jacks up an apex to drive the four radial brushes to move outwards respectively.

Abstract: Disclosed is a steering knuckle drilling device, including a drilling machine, a bottom plate, guide rails, hydraulic cylinders, fixtures, a support post and a support block. When in use, the present invention can simultaneously drill the left and right symmetric workpieces of a steering knuckle and can conveniently install and dismount the workpieces.

Abstract: A turnover fixture for wheel character carving. A rotation air cylinder and an angle block are mounted on a base, a first rotation shaft and a rotation shaft are connected with the rotation air cylinder through a rotation arm, the first rotation shaft and the base are connected through an end cover and a bearing, a support is fixed on the first rotation shaft.

Abstract: Disclosed are crystalline forms of (R)—N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide, and salts, solvates, and hydrates thereof, and pharmaceutical compositions, formulations and a process of manufacturing thereof.