Abstract: The present invention relates to biaryl monobactam compounds of Formula I and pharmaceutically acceptable salts thereof, wherein X, Y, Z, A1, Q, A2, M, W, RX and Rz are as defined herein. The present invention also relates to compositions which comprise a biaryl monobactam compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The invention further relates to methods for treating a bacterial infection comprising administering to the patient a therapeutically effective amount of a compound of the invention, either alone or in combination with a therapeutically effective amount of a second beta-lactam antibiotic.

Abstract: The present invention relates to monobactam compounds of Formula (I) and pharmaceutically acceptable salts thereof. The present invention also relates to compositions which comprise a monobactam compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The invention further relates to methods for treating a bacterial infection comprising administering to the patient a therapeutically effective amount of a compound of the invention, either alone or in combination with a therapeutically effective amount of a second beta-lactam antibiotic.

Abstract: Novel compounds of the structural formula I, and the pharmaceutically acceptable salts thereof, are inhibitors of TarO and may be useful in the prevention, treatment and suppression of diseases mediated by TarO, such as bacterial infections, including gram negative bacterial infections and gram positive bacterial infections such as MRSA and MRSE, alone or in combination with a ?-lactam antibiotic.

Abstract: The present disclosure may provide an atomizer and an electronic atomization device. The atomizer may include a shell, a heating assembly, a lid, a base, and a first sealing component. The shell defines a liquid cavity and a smoke outlet. The heating assembly may heat and atomize the liquid into a smoke. The lid and the base may be provided to fix the heating assembly therebetween. The lid defines a liquid inlet communicating with the liquid cavity, and the liquid may flow through to reach the heating assembly. The atomizer may define an air entering hole, such that external air may enter the device through the hole to drive smoke to flow. The first sealing component may be engaged between the lid and the heating assembly, contacting both at the same time and defining air guiding channels to guide the air to flow into the liquid cavity.

Abstract: A heating assembly, an atomizer and an electronic atomizing device are disclosed. The heating assembly includes a chassis and a heating component. The chassis may include a first wall having a top surface and a bottom surface opposite to the top surface, the first wall defining an air vent extending through the bottom surface, an air entering plate being connected with the first wall and covering the air vent, the air entering plate defining at least one air entering hole communicating with the installation space and the air vent, wherein the first wall and the second wall define the installation space. A heating component may be disposed in the installation space, a length of the at least one air vent is greater than that of the air entering hole in a direction from the bottom surface to the top surface.

Abstract: An atomizer (100) includes a liquid reservoir (120) and a heating assembly. The liquid reservoir (120) has a liquid storage cavity (122) for receiving an atomizing liquid, wherein the liquid reservoir (120) has an opening end (121). The heating assembly (130) includes a liquid conducting body (131) and the heating element (132), the liquid conducting body (131) is located on the opening end (121), the conducting body (131) has a liquid absorbing surface (131a) facing an inside of the liquid storage cavity (122) and a atomizing surface (131b) located outside of the liquid storage cavity (131b), the heating element (132) is formed on the atomizing surface (131b), the liquid conducting body (131) is configured to conduct the atomizing liquid in the liquid storage cavity (122) to the atomizing surface (131b), and the heating element (132) is configured to atomize the atomizing liquid conducted to the atomizing surface (131b).

Abstract: The invention disclosed a compound of general formula (I), a single stereoisomer thereof, a mixture of stereoisomers thereof, and a prodrug, pharmaceutically acceptable salt and metabolite thereof, X1, X2, X3, X4, R1, R2, x, y and z being as defined in the present invention.

Abstract: The present invention relates to biaryl monobactam compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein X, Y, Z, A1, Q, M, W, RX and Rz are as defined herein. The present invention also relates to compositions which comprise a biaryl monobactam compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The invention further relates to methods for treating a bacterial infection comprising administering to the patient a therapeutically effective amount of a compound of the invention, either alone or in combination with a therapeutically effective amount of a second beta-lactam antibiotic.

Abstract: A method of configuring a device includes associating a network-connectable device (such as a Wi-Fi thermostat) with a first identifier (such as a first account) established on a network server; using a mobile communication device (such as a smartphone), accessing the network-connectable device using the first identifier, and setting or verifying in the network-connectable device one or more operating parameters (such as a set-point) of the network-connectable device; after setting or verifying the one or more operating parameters, removing the association of the network-connectable device with the first identifier, and permitting association of the network-connectable device with a second identifier (such as a second account) established or to-be-established on a network server and access to the network-connectable device and verification or setting of the one or more operating parameters of the network-connectable device using the second identifier.

Abstract: A thermostat, of the type that employs latching relays to connect thermostat power to the various wires of the thermostat run, has a re-pulse feature that supplies latching pulses at a given interval, e.g., three hours, to ensure that the relays are in their proper state agreeing with the thermostat mode and the room temperature relative to the setpoint(s). In the case that the room air temperature is changing in a manner contrary to the current heating or cooling mode, which may indicate the latching relay has been knocked or bumped and needs to have its proper state re-established, the thermostat microprocessor issues pulses to the latching relay(s) more frequently, e.g., each 30 minutes, and the re-pulses may have a longer pulse width, e.g., increased from 20 ms to 25 ms.

Abstract: The present invention relates to compounds of formula I that are metallo-?-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with ?-lactam antibiotics for overcoming resistance.

Abstract: The invention disclosed a compound of general formula (I), a single stereoisomer thereof, a mixture of stereoisomers thereof, and a prodrug, pharmaceutically acceptable salt and metabolite thereof, X1, X2, X3, X4, R1, R2, x, y and z being as defined in the present invention.

Abstract: A touch-screen control panel interface has a dielectric flat or curved front panel and a printed circuit board with a front side and a reverse side which is the component side. Alphanumeric display module(s) or an LCD display and optional protective cap mounted on the reverse side of the circuit board are visible through window cutout(s) on the board. An array of LED indicators can be mounted on the back side of the circuit board and visible through cutouts in the board. Metallized capacitive pads on or adjacent the back side of the front panel at touch locations permit selection of various modes, functions, and settings. These pads may be formed on the flat front side of the circuit board, on the back of the front plate, or on an intermediate membrane. A microprocessor is connected with the various components and with capacitive pad. Icons may be printed onto the flat panel, in registry with the metallized capacitive electrode pads.