Abstract: The invention relates to a wide spectrum multi-band detection structure with selective absorption enhancement and its preparation method. The structure comprises a plurality of sub-pixel units capable of detecting incident light in different bands. Each sub-pixel unit is composed of a square well-shaped microstructure array and a metal lower electrode (2), a photosensitive layer (3) and an upper electrode (4) on the surface thereof. The size and array spacing of square well-shaped microstructures in different sub-pixel units are determined according to the detection bands of the sub-pixel units where they are located. The upper openings of the square well-shaped microstructures are hollow to form a resonant cavity, and the adjacent square well-shaped microstructures in the same sub-pixel unit form a resonant cavity, thus solving the problem that the detector structure in the prior art cannot simultaneously realize visible light-near infrared multi-band absorption enhancement detection.

Abstract: A chip crack detection apparatus includes a function circuit and a die crack detection module surrounding the function circuit. The die crack detection module includes a front-end-of-line device layer, a laminated structure on the front-end-of-line device layer that includes a conducting wire in the laminated structure, a detection interface, and a capacitor at the front-end-of-line device layer. A first end of the conducting wire is configured to connect to a positive electrode of a power supply. A second end of the conducting wire is configured to connect to a negative electrode of the power supply. The capacitor is connected in parallel between the first end and the second end of the conducting wire. The detection interface is coupled with the conducting wire between the first end and the second end of the conducting wire. The detection interface is configured to detect whether a die crack occurs in the chip.

Abstract: A chip crack detection apparatus is provided, to reduce interference to a function circuit while implementing die crack detection. The apparatus includes a function circuit (110) and a die crack detection module (120) located surrounding the function circuit (110). The die crack detection module (120) includes a front-end-of-line device layer (121) and a laminated structure (122) disposed on the front-end-of-line device layer (121), a conducting wire (L) is formed in the laminated structure (122), and one or more first capacitors (C1) are formed at the front-end-of-line device layer (121). A first end of the conducting wire (L) is configured to connect to a positive electrode of a power supply, and a second end of the conducting wire (L) is configured to connect to a negative electrode of the power supply.

Abstract: The present invention discloses a pharmaceutical composition for treating B-cell lymphoma, including a PI3K/AKT signaling pathway inhibitor and a chemotherapeutic drug, and further including a monoclonal antibody targeting CD20, such as rituximab. The pharmaceutical composition provided by the present invention is particularly suitable for the treatment of relapsed/refractory B-cell lymphoma. Given the critical role of cancer stem cells (CSCs) in the process of metastasis and drug resistance, the present invention proposes a new pro-differentiation therapy (PDT) strategy to cope with CSCs, i.e., to determine the decisive signaling pathway that maintains stem cell sternness and then promotes CSC differentiation by interfering with the pathway. Differentiated cells are eventually sensitive to conventional therapies, such as chemotherapy.

Abstract: An inhibitor targeting specific complement, the inhibitor targeting specific complement is a protein, the protein has a targeted inhibition function on the complement activation, and the amino acid sequence of the protein comprises CRIg extracellular domain and complement inhibiting domain; the amino acid sequence of the protein is consist of the CRIg extracellular domain and the complement inhibiting domain connected directly, or indirectly through a linker which can connect the two domains. The preparation method of the inhibitor targeting specific complement comprises connecting the protein polypeptides of the CRIg extracellular domain and the complement inhibiting domain by gene engineering technology. The protein can be used to prepare a drug targeting inhibition of complement activation.

Abstract: An inhibitor targeting specific complement, the inhibitor targeting specific complement is a protein, the protein has a targeted inhibition function on the complement activation, and the amino acid sequence of the protein comprises CRIg extracellular domain and complement inhibiting domain; the amino acid sequence of the protein is consist of the CRIg extracellular domain and the complement inhibiting domain connected directly, or indirectly through a linker which can connect the two domains The preparation method of the inhibitor targeting specific complement comprises connecting the protein polypeptides of the CRIg extracellular domain and the complement inhibiting domain by gene engineering technology. The protein can be used to prepare a drug targeting inhibition of complement activation.

Abstract: The invention features peptide fragments containing domain 4 of the Streptococcus intermedius intermedilysin (ILY) protein and the use of these fragments to sensitize cancer cells to antibody-based anticancer treatments. The invention also features use of these fragments to treat patients infected with microbial pathogens expressing CD59 or CD59-like molecules. CD59 receptor activity has been associated with decreased sensitivity to therapeutic and endogenously produced antibodies. Administration of ILY domain 4 polypeptides is sufficient to inhibit CD59 receptor activity while avoiding the general toxicity associated with full length ILY.

Abstract: The invention features proteins including an antibody, or functional derivatives thereof, that bind hCD59 and have the activity of domain 4 of the Streptococcus intermedins intermedilysin (ILY) protein. In order to prevent the independent induction of CDC and ADCC, the antibodies of the invention can bind the same hCD59 epitope as ILYd4 and/or contain modifications that disrupt the interaction between the antibody and complement.

Abstract: Ethylene propylene copolymers, substantially free of diene, are described. The copolymers will have a uniform distribution of both tacticity and comonomer between copolymer chains. Further, the copolymers will exhibit a statistically insignificant intramolecular difference of tacticity. The copolymers are made in the presence of a metallocene catalyst.

Abstract: The invention features proteins including an antibody, or functional derivatives thereof, that bind hCD59 and have the activity of domain 4 of the Streptococcus intermedins intermedilysin (ILY) protein. In order to prevent the independent induction of CDC and ADCC, the antibodies of the invention can bind the same hCD59 epitope as ILYd4 and/or contain modifications that disrupt the interaction between the antibody and complement.

Abstract: The invention described is a thermoplastic vulcanizate comprising dynamically-cured rubber, a functionalized thermoplastic polymer, and a functionalized hydrocarbon resin, which thermoplastic vulcanizate can be advantageously adhered to a polar substrate, for example by overmolding. In one or more embodiments of the present invention an article of commerce comprising: a) a polar substrate, and the b) a thermoplastic vulcanizate comprised of dynamically-cured rubber, a functionalized thermoplastic polymer, and a functionalized hydrocarbon resin; wherein said thermoplastic vulcanizate is adhered to the polar substrate is provided.

Abstract: Ethylene propylene copolymers, substantially free of diene, are described. The copolymers will have a uniform distribution of both tacticity and comonomer between copolymer chains. Further, the copolymers will exhibit a statistically insignificant intramolecular difference of tacticity. The copolymers are made in the presence of a metallocene catalyst.

Abstract: Ethylene propylene copolymers, substantially free of diene, are described. The copolymers will have a uniform distribution of both tacticity and comonomer between copolymer chains. Further, the copolymers will exhibit a statistically insignificant intramolecular difference of tacticity. The copolymers are made in the presence of a metallocene catalyst.

Abstract: A propylene copolymer is described comprising at least 70 mol % of units derived from propylene, up to 30 mol % of units derived from a combination of ethylene, at least one alpha-olefin having from 4 to 10 carbon atoms, such that the molar ratio of ethylene-derived units to said alpha-olefin-derived units in said combination is from about 1:9 to about 9:1, and from 0 to about 3 mol % of units derived from a copolymerizable diene. The copolymer has isotactically arranged propylene derived sequences, an overall heat of fusion as determined by differential scanning calorimetry (DSC) of less than 65 J/g, a second melting point as determined by DSC of less than 100° C., less than one 1,3 insertion error per 1000 carbon atoms and a weight average molecular weight as determined by gel permeation chromatography (GPC) of from about 100,000 to about 500,000.

Abstract: The invention features peptide fragments containing domain 4 of the Streptococcus intermedius intermedilysin (ILY) protein and the use of these fragments to sensitize cancer cells to antibody-based anticancer treatments. The invention also features use of these fragments to treat patients infected with microbial pathogens expressing CD59 or CD59-like molecules. CD59 receptor activity has been associated with decreased sensitivity to therapeutic and endogenously produced antibodies. Administration of ILY domain 4 polypeptides is sufficient to inhibit CD59 receptor activity while avoiding the general toxicity associated with full length ILY.

Abstract: A thermoplastic vulcanizate comprising (i) a dynamically-cured rubber, and (ii) a thermoplastic polymer component, where the thermoplastic polymer component includes (a) a propylene-?-olefin thermoplastic copolymer characterized by including at least 5% by weight up to 35% by weight units deriving from ?-olefins, and having a heat of fusion, as determined by DSC, of less than 80 J/g, (b) and a functionalized thermoplastic polymer.

Abstract: The invention features peptides containing domain 4 of the Streptococcus intermedius intermedilysin (ILY) protein and fragments thereof, and the use of these peptides to sensitize cancer cells to antibody based anticancer treatments. CD59 receptor activity has been associated with a decreased sensitivity to therapeutic antibodies. Desirably, administration of ILY domain 4 polypeptides is sufficient to inhibit CD59 receptor activity while avoiding the general toxicity associated with full length ILY.

Abstract: Disclosed herein are various compositions, including a transparent compositions comprising propylene-based polymers and a hydrocarbon resin.

Abstract: A thermoplastic elastomer having adhesion to steels, where the thermoplastic elastomer includes a dynamically crosslinked rubber, from more than 2.0 to 10 parts of a metal oxide or salt, and from 10 to 200 parts by weight of a functionalized polyolefin having pendant polar functional groups, where the polar functional groups are present at a level of 0.5 to 3.5 mole percent of the total repeating units of said functionalized polyolefin and the functionalized polyolefin is derived from polymerizing at least one monoolefin to form a semicrystalline polymer or is derived from hydrogenating the polydiene blocks of a block copolymer, and where the parts by weight are based on 100 parts by weight of crosslinked rubber.

Abstract: This invention provides methods of making molecular sieve catalyst particles, molecular sieve slurries that can be used in such methods, molecular sieve catalyst compositions and their use in catalytic hydrocarbon conversion processes. In one of its aspects, the invention provides a method of making molecular sieve catalyst particles, the method comprising the steps of: a) providing a solution or suspension of an aluminum-containing inorganic oxide precursor in a liquid medium; b) combining the solution or suspension of aluminum-containing inorganic oxide precursor with a molecular sieve, and optionally other formulating agents, to form a catalyst formulation slurry; c) aging the catalyst formulation slurry to generate in said slurry a percentage, or increase in said slurry the existing percentage, of aluminum atoms of the aluminum-containing precursor in the form of oligomers having a sharp 27 Al NMR peak at 62-63 ppm; and d) forming molecular sieve catalyst particles from the catalyst formulation slurry.