Abstract: The present disclosure is directed towards a treatment planning system for use in a stereotactic radiotherapy system. In particular, the disclosed systems and methods may be used for generating a treatment plan and/or verifying an existing treatment plan. Moreover, the disclosed systems and methods may be suitable for use in a clinical setting. A method for verifying a treatment plan of a stereotactic radiotherapy device may include the steps of receiving a treatment plan, generating a second treatment plan by applying a modified monte-carlo method to regions of interest in the treatment plan, and identifying discrepancies between the received treatment plan and the generated second treatment plan.

Abstract: The invention relates to a pressure maintaining gas cylinder valve. It consists of a pressure retaining device: The axis of the pressure retaining device and that of the valve element are in the same vertical plane; the pressure retaining device has a mounting base, a spring and a valve are located in the mounting base: the valve is in the valve element near the air outlet; the front section of the valve is near the air outlet, while the rear section of the valve is in the mounting base; the spring is between the valve and the mounting base. Because the invention has no eccentricity, the gas channel is smoother and the volume of the cylinder valve is greatly reduced. The mounting seat of the pressure retaining device not only provides support for the valve and spring, but also ensures that the stroke of the valve element is not interfered.

Abstract: A human ovarian cancer Niraparib-resistant cell strain and use thereof provided. A human ovarian cancer A2780 cell strain is selected as parental cell, and A2780-NiraR (preservation number: CCTCC NO: C202299) drug-resistant cell strain is established by gradually increasing concentration of PARP inhibitor Niraparib from 2 ?M to 40 ?M. Resistance index to Niraparib of A2780-NiraR is 8.274. In addition to resistance to Niraparib, A2780-NiraR cells are cross-resistant to Taxol. Moreover, the drug resistance of A2780-NiraR cell strain is re-tested as more than 90% of original after 3-month drug-withdrawal culture and 6-month liquid nitrogen cryopreservation and resuscitation following establishment, showing an excellent drug resistance stability. It can be used to study the tumor drug resistance mechanisms, analyze the susceptibility of chemotherapeutic drugs, screen and evaluate chemotherapeutic drugs, develop drug resistance reversal agents, and research more effective tumor treatment methods.

Abstract: A device receives border gateway protocol (BGP) data associated with links provided in a segment routing network. The segment routing network includes a first autonomous system (AS) with first network devices interconnected by a first portion of the links, a second AS with second network devices interconnected by a second portion of the links, and an inter-AS link provided between one of the first network devices and one of the second network devices. The device filters prefixes of the BGP data to identify BGP data associated with the inter-AS link, where the BGP data associated with the inter-AS link includes data identifying state information associated with the inter-AS link. The device determines an operational state of the inter-AS link based on the BGP data associated with the inter-AS link, and performs one or more actions based on the operational state of the inter-AS link.

Abstract: The invention relates to a pressure maintaining gas cylinder valve. It consists of a pressure retaining device: The axis of the pressure retaining device and that of the valve element are in the same vertical plane; the pressure retaining device has a mounting base, a spring and a valve are located in the mounting base: the valve is in the valve element near the air outlet; the front section of the valve is near the air outlet, while the rear section of the valve is in the mounting base; the spring is between the valve and the mounting base. Because the invention has no eccentricity, the gas channel is smoother and the volume of the cylinder valve is greatly reduced. The mounting seat of the pressure retaining device not only provides support for the valve and spring, but also ensures that the stroke of the valve element is not interfered.

Abstract: A device receives border gateway protocol (BGP) data associated with links provided in a segment routing network. The segment routing network includes a first autonomous system (AS) with first network devices interconnected by a first portion of the links, a second AS with second network devices interconnected by a second portion of the links, and an inter-AS link provided between one of the first network devices and one of the second network devices. The device filters prefixes of the BGP data to identify BGP data associated with the inter-AS link, where the BGP data associated with the inter-AS link includes data identifying state information associated with the inter-AS link. The device determines an operational state of the inter-AS link based on the BGP data associated with the inter-AS link, and performs one or more actions based on the operational state of the inter-AS link.

Abstract: A method and system for generating a voxel-based quadratic penalty model for automatic intensity modulated radiation therapy (IMRT) treatment planning are disclosed herein. A computing system generates an initial assignment of threshold values to a penalty function for IMRT treatment planning. The computing system receives an update to a dose value associated with the IMRT treatment planning. The computing system dynamically updates the threshold values based on the updated dose value. The computing system continues to iterate the threshold values based on further updated dose values.

Abstract: A device receives border gateway protocol (BGP) data associated with links provided in a segment routing network. The segment routing network includes a first autonomous system (AS) with first network devices interconnected by a first portion of the links, a second AS with second network devices interconnected by a second portion of the links, and an inter-AS link provided between one of the first network devices and one of the second network devices. The device filters prefixes of the BGP data to identify BGP data associated with the inter-AS link, where the BGP data associated with the inter-AS link includes data identifying state information associated with the inter-AS link. The device determines an operational state of the inter-AS link based on the BGP data associated with the inter-AS link, and performs one or more actions based on the operational state of the inter-AS link.

Abstract: A multifunctional chair is disclosed, including: a first frame body unit, the first frame body unit including a head end and a tail end; a first supporting unit configured to support the first frame body unit, the first supporting unit connected with a first connecting position of the first frame body unit and a height of the tail end of the first frame body unit being lower than a height of the first connecting position; a first leaning unit arranged in a position of the first frame body unit close to the first connecting position; a second frame body unit arranged on a back portion of the first frame body unit, the second frame body unit and the first frame body unit being rotatably connected, the second frame body unit and the first frame body unit in rotatable connection being capable of moving between a first posture of a reclining chair or a seat and a second posture of fitness equipment, the second frame body unit and the first frame body unit being in the first posture when having an angle, and the se

Abstract: Systems, methods, and computer-readable storage media providing techniques for probing in-vivo beam ranges directly using therapeutic beams for particle therapy treatment are disclosed. In an embodiment, a configuration is determined for one or more probing spots, each spot corresponding to a planned location within an interior region of a tumor volume where a dose of radiation is to be delivered. At least one therapeutic beam is provided to the tumor volume, and one or more images may be captured to provide an indication of the range/depth of the probing spots. Providing the probing spots to the interior of the tumor volume reduces the risk that the dose is provided to sensitive tissue (e.g., because even if the dose is delivered to a location other than the planned location, the dose is likely to remain contained within the tumor volume).

Abstract: A device receives border gateway protocol (BGP) data associated with links provided in a segment routing network. The segment routing network includes a first autonomous system (AS) with first network devices interconnected by a first portion of the links, a second AS with second network devices interconnected by a second portion of the links, and an inter-AS link provided between one of the first network devices and one of the second network devices. The device filters prefixes of the BGP data to identify BGP data associated with the inter-AS link, where the BGP data associated with the inter-AS link includes data identifying state information associated with the inter-AS link. The device determines an operational state of the inter-AS link based on the BGP data associated with the inter-AS link, and performs one or more actions based on the operational state of the inter-AS link.

Abstract: A device receives border gateway protocol (BGP) data associated with links provided in a segment routing network. The segment routing network includes a first autonomous system (AS) with first network devices interconnected by a first portion of the links, a second AS with second network devices interconnected by a second portion of the links, and an inter-AS link provided between one of the first network devices and one of the second network devices. The device filters prefixes of the BGP data to identify BGP data associated with the inter-AS link, where the BGP data associated with the inter-AS link includes data identifying state information associated with the inter-AS link. The device determines an operational state of the inter-AS link based on the BGP data associated with the inter-AS link, and performs one or more actions based on the operational state of the inter-AS link.

Abstract: Methods, apparatuses, systems, and implementations for creating a patient-specific soft bolus for radiotherapy treatment are disclosed. 2D and/or 3D images of a desired radiotherapy treatment site may be acquired, such as the head, neck, skin, breast, anus, and/or vulva. A user may interact with one or more representations of the images via an interactive user interface such as a graphical user interface (GUI). The images may include target/avoidance structures and radiation beam arrangement. The user may interact with the images to create a visualization of a patient-specific bolus. The visualization and properties of the bolus may be modified as the user manipulates aspects of the image. Data corresponding to the bolus models may be used to create 3D printed negative molds of the bolus model using 3D printing technology. A soft patient-specific bolus may be cast using the 3D printed model.

Abstract: A method and system for generating a voxel-based quadratic penalty model for automatic intensity modulated radiation therapy (IMRT) treatment planning are disclosed herein. A computing system generates an initial assignment of threshold values to a penalty function for IMRT treatment planning The computing system receives an update to a dose value associated with the IMRT treatment planning The computing system dynamically updates the threshold values based on the updated dose value. The computing system continues to iterate the threshold values based on further updated dose values.

Abstract: Methods, apparatuses, systems, and implementations for creating a patient-specific soft bolus for radiotherapy treatment are disclosed. 2D and/or 3D images of a desired radiotherapy treatment site may be acquired, such as the head, neck, skin, breast, anus, and/or vulva. A user may interact with one or more representations of the images via an interactive user interface such as a graphical user interface (GUI). The images may include target/avoidance structures and radiation beam arrangement. The user may interact with the images to create a visualization of a patient-specific bolus. The visualization and properties of the bolus may be modified as the user manipulates aspects of the image. Data corresponding to the bolus models may be used to create 3D printed negative molds of the bolus model using 3D printing technology. A soft patient-specific bolus may be cast using the 3D printed model.

Abstract: Systems, methods, and computer-readable storage media providing techniques for probing in-vivo beam ranges directly using therapeutic beams for particle therapy treatment are disclosed. In an embodiment, a configuration is determined for one or more probing spots, each spot corresponding to a planned location within an interior region of a tumor volume where a dose of radiation is to be delivered. At least one therapeutic beam is provided to the tumor volume, and one or more images may be captured to provide an indication of the range/depth of the probing spots. Providing the probing spots to the interior of the tumor volume reduces the risk that the dose is provided to sensitive tissue (e.g., because even if the dose is delivered to a location other than the planned location, the dose is likely to remain contained within the tumor volume).

Abstract: A system and method of delivering a radiation therapy treatment plan to a patient. The treatment plan is delivered using a radiation therapy system including a moveable support for supporting a patient, a gantry moveable relative to the support and supporting a radiation source and multi-leaf collimator for modulating the radiation source. The support and gantry are moved during delivery of the treatment plan.

Abstract: The invention relates to a safety valve for a cryogenic insulated gas cylinder, which comprises a valve body, and the valve body further comprises a gas inlet flow channel, a valve seat, a slide way, a valve core and a spring, a gas inlet connecting thread and an adjusting nut. An adjusting nut exhaust hole set on said adjusting nut, a spring set between the said adjusting nut and a spring bracket with an exhaust hole. A valve assembly further comprises the valve core, a plurality of guide rings, a positioning steel ball and a valve flap, a valve core exhaust hole is provided in the valve core. The safety valve has high stability in discharge pressure and return pressure, high repeatability and good sealing performance, and is firm in structure, difficult to be damaged and high in safety.

Abstract: The invention relates to a safety valve for a cryogenic insulated gas cylinder, which comprises a valve body, and the valve body further comprises a gas inlet flow channel, a valve seat, a slide way, a valve core and a spring, a gas inlet connecting thread and an adjusting nut. An adjusting nut exhaust hole set on said adjusting nut, a spring set between the said adjusting nut and a spring bracket with an exhaust hole. A valve assembly further comprises the valve core, a plurality of guide rings, a positioning steel ball and a valve flap, a valve core exhaust hole is provided in the valve core. The safety valve has high stability in discharge pressure and return pressure, high repeatability and good sealing performance, and is firm in structure, difficult to be damaged and high in safety.

Abstract: A system for and method of delivering radiation therapy to a moving region of interest is disclosed. The method, in one implementation, includes the acts of generating a plurality of treatment plans for providing radiation therapy, delivering radiation therapy to the patient following one of the plurality of treatment plans, monitoring the patient while providing radiation therapy, and changing the treatment plan based at least in part on monitoring the patient.