Patents by Inventor Weiguo YAO

Weiguo YAO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250049846
    Abstract: The invention provides compositions and methods for treating a patient with cancer with an immune cell, e.g., a T-cell, e.g., an engineered T-cell, with increased sialidase activity. The invention also provides compositions and methods for treating a patient with cancer with an immune cell, e.g., a T-cell, e.g., an engineered T-cell, in combination with a sialidase. The invention also provides compositions and methods for treating a patient with cancer with an immune cell, e.g., a T-cell, e.g., an engineered T-cell, pretreated with a sialidase.
    Type: Application
    Filed: January 3, 2020
    Publication date: February 13, 2025
    Inventors: Ahmed Alkhateeb, Karl D. Normington, Li Peng, James W. Broderick, Zakir B. Siddiquee, Jenny Che, Weiguo Yao, Abhishek Das
  • Publication number: 20230263742
    Abstract: The invention provides a lipid of Formula (I) and nanoparticle compositions containing the same. Nanoparticle compositions including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
    Type: Application
    Filed: May 5, 2022
    Publication date: August 24, 2023
    Inventors: Yunsong CAI, Lei HUANG, Na LIU, Yu HANG, Weiguo YAO, Yujian ZHANG, Hangwen LI, Haifa SHEN
  • Publication number: 20220387616
    Abstract: The invention relates generally to recombinant sialidase and anti-HER2 immunoglobulin antigen-binding domain fusion proteins. The invention also provides antibody conjugates including a sialidase and an anti-HER2 antibody or a portion thereof. The invention further relates to methods of using the sialidase fusion proteins or antibody conjugates for treating cancer.
    Type: Application
    Filed: July 3, 2020
    Publication date: December 8, 2022
    Inventors: Li Peng, Lizhi Cao, Wayne C. Gatlin, Weiguo Yao, Zakir B. Siddiquee, Sujata B. Nerle, Jenny Che
  • Patent number: 10458862
    Abstract: A fiber grating sensor insert, implanting system and method of an intelligent plastic pipe.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: October 29, 2019
    Assignees: SHANDONG UNIVERSITY, CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY, CHINESE ACADEMY OF SCIENCES, JILIN CORE LOGISTICS AND COATING EQUIPMENT CO., LTD., SHANDONG GELNNT ENVIRONMENTAL TECHNOLOGY CO., LTD.
    Inventors: Yuxi Jia, Linlin Gao, Lijia An, Weiguo Yao, Guoshun Wan, Hui Ye, Leida Zhang
  • Patent number: 10399286
    Abstract: A composite material packaged fiber grating sensor and a manufacturing method thereof. The sensor includes a fiber grating sensor component, a composite material coverage layer, a resin package layer and a composite material substrate layer. In the sensor, a temperature fiber grating and a strain fiber grating are packaged in a composite material structure, so that the structure is light and simple, its computability with the composite material is good, the measurement accuracy is high, and the survival rate and the service life of the installed sensor can be greatly improved, the sensor component can be externally pasted on to or inter-implanted in a composite material structural part, and can be applied to the distributed online health monitoring on the structural part. The manufacturing method of the composite material packaged fiber grating sensor is simple, efficient and stable, and is suitable for rapid mass production by enterprises.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: September 3, 2019
    Assignees: SHANDONG UNIVERSITY, CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY, CHINESE ACADEMY OF SCIENCES, JILIN CORE LOGISTICS AND COATING EQUIPMENT CO., LTD., SHANDONG GELNNT ENVIRONMENTAL TECHNOLOGY CO., LTD.
    Inventors: Yuxi Jia, Yunli Guo, Lijia An, Weiguo Yao, Linlin Gao, Qinglin Wang, Mingshun Jiang, Haiqing Wang, Jieying Zhi, Yaru Zhao, Qingmei Sui
  • Publication number: 20190212213
    Abstract: A fiber grating sensor insert, implanting system and method of an intelligent plastic pipe.
    Type: Application
    Filed: September 28, 2017
    Publication date: July 11, 2019
    Applicants: SHANDONG UNIVERSITY, SHANDONG UNIVERSITY, CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY, CHINESE ACADEMY OF SCIENCES, CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY, CHINESE ACADEMY OF SCIENCES, JILIN CORE LOGISTICS AND COATING EQUIPMENT CO., LTD., JILIN CORE LOGISTICS AND COATING EQUIPMENT CO., LTD., SHANDONG GELNNT ENVIRONMENTAL TECHNOLOGY CO., LTD., SHANDONG GELNNT ENVIRONMENTAL TECHNOLOGY CO., LTD.
    Inventors: Yuxi JIA, Linlin GAO, Lijia AN, Weiguo YAO, Guoshun WAN, Hui YE, Leida ZHANG
  • Publication number: 20190016065
    Abstract: A composite material packaged fiber grating sensor and a manufacturing method thereof. The sensor includes a fiber grating sensor component, a composite material coverage layer, a resin package layer and a composite material substrate layer. In the sensor, a temperature fiber grating and a strain fiber grating are packaged in a composite material structure, so that the structure is light and simple, its computability with the composite material is good, the measurement accuracy is high, and the survival rate and the service life of the installed sensor can be greatly improved, the sensor component can be externally pasted on to or inter-implanted in a composite material structural part, and can be applied to the distributed online health monitoring on the structural part. The manufacturing method of the composite material packaged fiber grating sensor is simple, efficient and stable, and is suitable for rapid mass production by enterprises.
    Type: Application
    Filed: September 28, 2017
    Publication date: January 17, 2019
    Applicants: SHANDONG UNIVERSITY, CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY, CHINESE ACADEMY OF SCIENCES, JILIN CORE LOGISTICS AND COATING EQUIPMENT CO., LTD., SHANDONG GELNNT ENVIRONMENTAL TECHONOLOGY CO., LTD.
    Inventors: Yuxi JIA, Yunli GUO, Lijia AN, Weiguo YAO, Linlin GAO, Qinglin WANG, Mingshun JIANG, Haiqing WANG, Jieying ZHI, Yaru ZHAO, Qingmei SUI