Patents by Inventor Weihe Zhang

Weihe Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrimidine compounds for the treatment of cancer
    Patent number: 9567326
    Abstract: Described are compounds of Formula I or Formula II: wherein: ring A is a 5- or 6-membered heteroaryl group; dashed lines are optional double bonds; X is N or O; Y is a carbon atom or an S or N heteroatom in ring A in any suitable location; and substituents are as given herein. Compositions containing the same and methods of using the same in treating cancers such as acute lymphoblastic leukemia are also described.
    Type: Grant
    Filed: May 21, 2013
    Date of Patent: February 14, 2017
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Xiaodong Wang, Weihe Zhang, Dmitri Kireev, Dehui Zhang, Andrew McIver
  • Pyrazolopyrimidine compounds for the treatment of cancer
    Patent number: 9562047
    Abstract: Compounds of Formula I are described, along with pharmaceutically acceptable salts thereof, compositions containing the same, and methods of use thereof.
    Type: Grant
    Filed: October 16, 2013
    Date of Patent: February 7, 2017
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Xiaodong Wang, Jing Liu, Chao Yang, Weihe Zhang, Stephen Frye, Dmitri Kireev
  • Therapeutic uses of selected pyrrolopyrimidine compounds with anti-mer tyrosine kinase activity
    Patent number: 9555031
    Abstract: Uses of pyrrolopyrimidines with anti-Mer tyrosine kinase activity as anti-infective agents, immunostimulatory and immunomodulatory agents, anti-cancer agents (including against MerTK?/? tumors and ITD and TKD mutant forms of Acute Myeloid Leukemia (AML)), and as adjunctive agents in combination with chemotherapeutic, radiation or other standard of care for neoplasms.
    Type: Grant
    Filed: April 3, 2015
    Date of Patent: January 31, 2017
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Xiaodong Wang, Weihe Zhang, Stephen Frye
  • PYRAZOLOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER
    Publication number: 20160279132
    Abstract: Compound of Formula I: are described, along with pharmaceutically acceptable salts thereof, compositions containing the same, and methods of use thereof in the treatment of cancer.
    Type: Application
    Filed: February 29, 2016
    Publication date: September 29, 2016
    Inventors: Xiaodong Wang, Jing Liu, Chao Yang, Weihe Zhang, Stephen Frye, Dmitri Kireev
  • PYRROLOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER
    Publication number: 20160151372
    Abstract: Compounds of Formula I: wherein: one of X and X? is N and the other of X and X? is C, are described, along with compositions containing the same and methods of use thereof in the treatment of cancer.
    Type: Application
    Filed: February 3, 2016
    Publication date: June 2, 2016
    Inventors: Xiaodong Wang, Jing Liu, Weihe Zhang, Stephen Frye, Dmitri Kireev
  • Pyrrolopyrimidine compounds for the treatment of cancer
    Patent number: 9273056
    Abstract: The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemia (ALL) cells and a potential cause of ALL chemoresistance. Hence, we investigated whether the development of small molecule Mer inhibitors was possible. A first aspect of the present invention is a compound (sometimes referred to as an “active compound” herein) of Formula I, IA, or IB.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: March 1, 2016
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Xiaodong Wang, Jing Liu, Weihe Zhang, Stephen Frye, Dmitri Kireev
  • PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER
    Publication number: 20150322019
    Abstract: Compounds of Formula I or II: are described, along with pharmaceutical compositions containing the same and methods of using such compounds for the treatment of cancer.
    Type: Application
    Filed: November 22, 2013
    Publication date: November 12, 2015
    Inventors: Xiaodong Wang, Weihe Zhang, Dmitri Kireev, Jing Liu, Andrew Louis Mclver
  • THERAPEUTIC USES OF SELECTED PYRIMIDINE COMPOUNDS WITH ANTI-MER TYROSINE KINASE ACTIVITY
    Publication number: 20150290194
    Abstract: Uses of pyrimidines with anti-Mer tyrosine kinase activity as anti-infective agents, immunostimulatory and immunomodulatory agents, anti-cancer agents (including against MerTK ?/? tumors and ITD and TKD mutant forms of Acute Myeloid Leukemia (AML)), and as adjunctive agents in combination with chemotherapeutic, radiation or other standard of care for neoplasms.
    Type: Application
    Filed: April 3, 2015
    Publication date: October 15, 2015
    Inventors: Xiaodong Wang, Weihe Zhang, Stephen Frye
  • MERTK-SPECIFIC PYRROLOPYRIMIDINE COMPOUNDS
    Publication number: 20150291606
    Abstract: The present invention includes pyrrolopyrimidine compounds that selectively inhibit Mer tyrosine kinase (MerTK) activity and/or Tyro3 tyrosine kinase activity, and use of these pyrrolopyrimidine compounds as anti-cancer agents, immunostimulatory and immunomodulatory agents, anti-platelet agents, anti-infective agents, and as adjunctive agents in combination with chemotherapeutic, radiation or other standard of care for neoplasms.
    Type: Application
    Filed: April 3, 2015
    Publication date: October 15, 2015
    Inventors: Xiaodong Wang, Weihe Zhang, Stephen Frye, Dmitri Kireev
  • THERAPEUTIC USES OF SELECTED PYRROLOPYRIMIDINE COMPOUNDS WITH ANTI-MER TYROSINE KINASE ACTIVITY
    Publication number: 20150290197
    Abstract: Uses of pyrrolopyrimidines with anti-Mer tyrosine kinase activity as anti-infective agents, immunostimulatory and immunomodulatory agents, anti-cancer agents (including against MerTK?/? tumors and ITD and TKD mutant forms of Acute Myeloid Leukemia (AML)), and as adjunctive agents in combination with chemotherapeutic, radiation or other standard of care for neoplasms.
    Type: Application
    Filed: April 3, 2015
    Publication date: October 15, 2015
    Inventors: Xiaodong Wang, Weihe Zhang, Stephen Frye
  • PYRAZOLOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER
    Publication number: 20150284392
    Abstract: Compounds of Formula I are described, along with pharmaceutically acceptable salts thereof, compositions containing the same, and methods of use thereof.
    Type: Application
    Filed: October 16, 2013
    Publication date: October 8, 2015
    Inventors: Xiaodong Wang, Jing Liu, Chao Yang, Weihe Zhang, Stephen Frye, Dmitri Kireev
  • PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER
    Publication number: 20150038481
    Abstract: Described are compounds of Formula I or Formula II: wherein: ring A is a 5- or 6-membered heteroaryl group; dashed lines are optional double bonds; X is N or O; Y is a carbon atom or an S or N heteroatom in ring A in any suitable location; and substituents are as given herein. Compositions containing the same and methods of using the same in treating cancers such as acute lymphoblastic leukemia are also described.
    Type: Application
    Filed: May 21, 2013
    Publication date: February 5, 2015
    Inventors: Xiaodong Wang, Weihe Zhang, Dmitri Kireev, Dehui Zhang, Andrew Mclver
  • PYRROLOPYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER
    Publication number: 20140243315
    Abstract: The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemia (ALL) cells and a potential cause of ALL chemoresistance. Hence, we investigated whether the development of small molecule Mer inhibitors was possible. A first aspect of the present invention is a compound (sometimes referred to as an “active compound” herein) of Formula I, IA, or IB.
    Type: Application
    Filed: October 1, 2012
    Publication date: August 28, 2014
    Applicant: The University of North Carolina at Chapel Hill
    Inventors: Xiaodong Wang, Jing Liu, Weihe Zhang, Stephen Frye, Dmitri Kireev