Abstract: The present invention relates to a polypeptide comprising 7 ?-strands A, B, C, D, E, F, and G sequentially connected together by connecting chains of amino acids, and a first ?-helix sequentially located on the EF chain between ?-strands E and F, wherein the ?-strands are arranged so as to form a first ?-sheet comprising ?-strands A, B, D, and E, and a second ?-sheet comprising ?-strands C, F and G, said first and second ?-sheets being covalently bonded together so as to form a first Ig domain; wherein the EF chain between ?-strands E and F comprises the sequence X1-X2-X3-X4-K5H6 (SEQ ID NO:98), and X1, X3 and X4 are each independently any amino acid residue, characterized in that X2 is selected from the group consisting of A, G, I, V, L, R, S, T, Q, P, N, M, H, W, and pharmaceutically acceptable salts, stereoisomers, tautomers, solvates, and prodrugs thereof.

Abstract: The present invention relates to a polypeptide comprising 7 ?-strands A, B, C, D, E, F, and G sequentially connected together by connecting chains of amino acids, and a first ?-helix sequentially located on the EF chain between ?-strands E and F, wherein the ?-strands are arranged so as to form a first ?-sheet comprising ?-strands A, B, D, and E, and a second ?-sheet comprising ?-strands C, F and G, said first and second ?-sheets being covalently bonded together so as to form a first Ig domain; wherein the EF chain between ?-strands E and F comprises the sequence X1-X2-X3-X4-K5H6 (SEQ ID NO:98), and X1, X3 and X4 are each independently any amino acid residue, characterized in that X2 is selected from the group consisting of A, G, I, V, L, R, S, T, Q, P, N, M, H, W, and pharmaceutically acceptable salts, stereoisomers, tautomers, solvates, and prodrugs thereof

Abstract: A cosmetic composition containing: (a) at least one tackifier component having a solubility parameter corresponding to ?; (b) at least one liposoluble polymer having at least one segment with a solubility parameter corresponding to ?+2; (c) at least one solvent; and (d) optionally, at least one colorant.

Abstract: The present invention relates to Multifunctional Antibody Conjugates, comprising an antibody or antigen binding portion thereof, comprising at least a fragment of a light chain constant kappa region (CL?) comprising K188 according to Kabat numbering; a linker comprising the formula X-Y-Z, wherein Z is a group is covalently connected to the antibody through the side chain of K188, Y is a linear or branched biologically compatible connecting chain, and X is a group covalently connected to at least one Effector Moiety. The invention further provides specific MAC compounds and compositions of the invention.

Abstract: The invention relates to compositions containing at least one polyorganosiloxane-containing polymer, at least one volatile non-silicone oil, at least one alkylene polymer wax, at least one silicone film-forming agent and, optionally, at least one long-chain alcohol wax, at least one coloring agent, and/or at least one volatile silicone oil, as well as to methods for using such compositions and to kits containing such compositions.

Abstract: A cosmetic composition and process which provides enhanced wear, comfort and feel, the composition containing: (a) at least one polypropylsilsesquioxane film forming resin; (b) at least one polymer chosen from a polyorganosiloxane copolymer and a silicone acrylate copolymer; (c) at least one solvent; and (d) optionally, at least one colorant.

Abstract: The present invention relates to Multifunctional Antibody Conjugates, comprising an antibody or antigen binding portion thereof, comprising at least a fragment of a light chain constant kappa region (CL?) comprising K188 according to Kabat numbering; a linker comprising the formula X-Y-Z, wherein Z is a group is covalently connected to the antibody through the side chain of K188, Y is a linear or branched biologically compatible connecting chain, and X is a group covalently connected to at least one Effector Moiety. The invention further provides specific MAC compounds and compositions of the invention.

Abstract: A cosmetic composition and process which provides enhanced wear and transfer resistance containing: (a) at least one polypropylsilsesquioxane film forming resin; (b) at least one solvent; and (c) optionally, at least one colorant.

Abstract: The present invention relates to a cosmetic composition containing a phenyl substituted organosiloxane to provide shine and/or gloss when applied to a keratinous material, such as skin.

Abstract: The invention relates to compositions containing at least one polyorganosiloxane-containing polymer, at least one volatile non-silicone oil, at least one alkylene polymer wax, at least one silicone film-forming agent and, optionally, at least one long-chain alcohol wax, at least one coloring agent, and/or at least one volatile silicone oil, as well as to methods for using such compositions and to kits containing such compositions.

Abstract: Personal care dissolvable films comprising a water soluble film forming agent, cosmetically acceptable plasticizer, and detackifying agent are described, along with methods of using the same.

Abstract: The present invention provides personal care compositions in film form having greater than about 30 weight percent water-soluble chitosan derivative.

Abstract: The invention relates to compositions containing at least one polyorganosiloxane-containing polymer, at least one volatile non-silicone oil, at least one alkylene polymer wax, at least one silicone film-forming agent and, optionally, at least one long-chain alcohol wax, at least one coloring agent, and/or at least one volatile silicone oil, as well as to methods for using such compositions and to kits containing such compositions.

Abstract: The present invention provides personal care compositions in film form having less than about 30 weight percent water-soluble chitosan derivative and greater than about 40 weight percent of a water soluble film forming agent.

Abstract: Personal care dissolvable films comprising a water soluble film forming agent, cosmetically acceptable plasticizer, and a thickener are described, along with methods of using the same.

Abstract: A cosmetic composition containing: (a) at least one tackifier component having a solubility parameter corresponding to ?; (b) at least one liposoluble polymer having at least one segment with a solubility parameter corresponding to ?+2; (c) at least one solvent; and (d) optionally, at least one colorant.

Abstract: Shine-enhancing film formers are used to formulate cosmetic compositions in which shine is a desired property. Shine-enhancing film formers may be used alone for a high degree of shine or in combination with other film formers to modify the degree of shine. Using shine-enhancing film formers in cosmetics compositions often accomplishes increased shine properties while retaining other properties favorable to cosmetic compositions such as transfer-resistance.

Abstract: A personal care composition comprising an alkylene oxide-lactone based polymer, the polymer comprising an alkylene oxide and a lactone in copolymerized form, is useful for treating hair and skin.