Abstract: Provided herein are substituted fused quadracyclic compounds useful as inhibitors of MK2. The invention further provides pharmaceutical compositions of the compounds of the invention. The invention also provides medical uses of substituted fused quadracyclic compounds.

Abstract: The present disclosure relates to a respiratory syncytial virus (RSV)-specific binding molecule and an application thereof. The present disclosure also provides a preparation method of the above molecule, and an application of the molecule in the preparation of a product that specifically binds to the RSV surface fusion glycoprotein and the preparation of an RSV vaccine, etc.

Abstract: The invention describes fully native human neutralizing monoclonal antibodies against tetanus toxin. The invention developed fully native human neutralizing monoclonal antibodies against tetanus toxin through a systematic high through-put platform that is specialized for identifying and developing human native antibody. The neutralizing monoclonal antibodies described in the invention can be used in the prevention, treatment and detection of Clostridium tetani infection. The fully human neutralizing monoclonal antibodies developed in the invention have a high affinity toward tetanus toxin, as well as possessing high neutralizing activities against the toxin, safe of use with high disease prevention effectiveness, free of exogenous virus contamination, and are widely applicable to various human groups with strong industrial applications.

Abstract: The present invention relates to neutralizing monoclonal antibodies or antigen-binding fragments thereof that are specific for and bind with high affinity to Varicella-Zoster Virus, and a preparation method for producing such antibodies. The antibodies of the present invention have high efficiency in neutralizing Varicella-Zoster Virus infection. The present invention also relates to the epitope to which the antibodies bind and the use of the antibodies in the diagnosis, prevention and treatment of infected individuals.

Abstract: Provided are a neutralizing antibody, which can specifically bind to NGF, or an antigen-binding fragment thereof, and a preparation method for producing the antibody. Further provided is an application of the antibody in the treatment of NGF-related diseases or disorders, especially in relieving or improving individual pain.

Abstract: Disclosed are a monoclonal antibody that is specific to human cytomegalovirus and binds to human cytomegalovirus with a high affinity, or an antigen-binding fragment thereof, and a method for preparing the antibody. The antibody is also highly effective in neutralizing infections. Also disclosed are an epitope to which the antibody binds, and the use of the antibody in the diagnosis, prevention and treatment of an infected individual.

Abstract: The present disclosure discloses methods and apparatuses for wave recognition, and unmanned aerial vehicles. The method includes: extracting a first image acquired by an image acquisition apparatus at a first moment and a second image acquired by the image acquisition apparatus at a second moment; extracting a target region in each of the first image and the second image; comparing feature information of the target region in the first image with feature information of the target region in the second image; and determining whether the target region is a wave according to a result of the comparing of the feature information. The methods and apparatuses for wave recognition, and unmanned aerial vehicles recognize a wave in an image based on the change of feature information of a target region in the image at different times.

Abstract: The present disclosure relates to a visual field testing method, system, and testing apparatus based on head-mounted testing equipment. The method includes: transmitting, by the testing apparatus in electronic equipment, a start notification for starting monitoring of a movement trajectory of a pupil of a current eye to be tested to an eye movement tracking system after receiving a start test instruction transmitted from a controller; receiving, by the testing apparatus, movement state information of the pupil that is transmitted from the eye movement tracking system; and determining, by the testing apparatus, the movement trajectory of the pupil according to the movement state information, wherein the controller is a component that is associated with the head-mounted testing equipment and communicatively connected to the testing apparatus of the electronic equipment.

Abstract: The invention describes fully native human neutralizing monoclonal antibodies against tetanus toxin. The invention developed fully native human neutralizing monoclonal antibodies against tetanus toxin through a systematic high through-put platform that is specialized for identifying and developing human native antibody. The neutralizing monoclonal antibodies described in the invention can be used in the prevention, treatment and detection of Clostridium tetani infection. The fully human neutralizing monoclonal antibodies developed in the invention have a high affinity toward tetanus toxin, as well as possessing high neutralizing activities against the toxin, safe of use with high disease prevention effectiveness, free of exogenous virus contamination, and are widely applicable to various human groups with strong industrial applications.

Abstract: A communication method including a first device sending a registration request to a second device through a Universal Serial Bus (USB) interface of the first device. The registration request requests to register the first device with the second device and includes registration information of the first device. The registration information includes a registration key. The method further includes the first device receiving a registration response through the USB interface. The registration response is sent by the second device according to the registration key and confirms the first device is successfully registered with the second device. The method also includes the first device communicating with the second device via the USB interface.

Abstract: The present disclosure relates to a visual field testing method, system, and testing apparatus based on head-mounted testing equipment (02). The method includes: transmitting, by the testing apparatus in electronic equipment (01), a start notification for starting monitoring of a movement trajectory of a pupil of a current eye to be tested to an eye movement tracking system (03) after receiving a start test instruction transmitted from a controller; receiving, by the testing apparatus, movement state information of the pupil (202) that is transmitted from the eye movement tracking system (03); and determining, by the testing apparatus, the movement trajectory (203) of the pupil according to the movement state information, wherein the controller is a component that is associated with the head-mounted testing equipment (02) and communicatively connected to the testing apparatus of the electronic equipment (01). The method can reduce the testing complexity and may also improve the testing accuracy and comfort.

Abstract: Compounds having methyltransferase inhibitory activity are disclosed. The compounds have the structure and are useful in the treatment of cancer and similar diseases associated with inappropriate methyltransferase activity.

Abstract: Compounds having methyltransferase inhibitory activity are disclosed. The compounds have the structure and are useful in the treatment of cancer and similar diseases associated with inappropriate methyltransferase activity.

Abstract: Compounds having methyltransferase inhibitory activity are disclosed. The compounds have the structure and are useful in the treatment of cancer and similar diseases associated with inappropriate methyltransferase activity.

Abstract: The present invention relates to a walkman, particularly to a network walkman which can perform collinear transmission of USB connecting line and audio earphone line. It is mainly characterized in that a switch integrated circuit is added to the conventional circuit to perform the automatic switch-over between the USB interface and the audio output interface, so as to realize the function of collinear transmission of the USB connecting line and the audio earphone line. On the basis of the conventional technique, said two interfaces are simplified as a single interface, which can both obtain more preferable appearance and reduce the cost. Therefore, this invention is convenient for the users and has good applicable function.