Abstract: A computer-implemented bone-implant system evaluation method for application of mesh-free analysis of a bone-implant system for evaluation of performance of a bone-implant system for an implant implanted within the bone structure at an anatomical site, said method comprising (i) receiving a set of bone structure data set, wherein set of bone structure data includes data indicative of the bone structure at an anatomical site; (ii) inputting an implant data set and inputting the position of the implant data set, wherein the implant is selected based upon the biomechanical requirements for the anatomical site and the position and of the implant data set is indicative of the position of the implant with respect to the anatomical site, wherein implant data set includes data representative of the geometry and materials properties of the implant; (iii) creating a bone-implant model, wherein said bone implant-model includes a mesh-free model of trabecular bone at the anatomical site wherein the bone-implant model is

Abstract: Devices and methods for the removal of bone implant tips from within a bony structure in a body. The device or method includes a shaft with an internal grasping feature capable of being inserted while remaining in an un-expanded, un-deployed state. This permits a surgeon or operator to insert the device while in a small profile state, avoiding or reducing damage to adjacent bone tissue during insertion. Upon insertion of the shaft to the proper position within a patient's bone, the grasping feature may then be expanded or deployed from the distal end of the shaft by a surgeon or operator using an actuator in a handle attached to the proximal end of the shaft. Following deployment, the grasping feature may be used to manipulate and/or remove a bone implant tip from a patient's bone tissue. Embodiments of the grasping feature include one or more hooks, wires, articulating fingers, and/or net-based designs formed of metal, polymer, composite, or a combination thereof.

Abstract: A computer-implemented bone-implant system evaluation method for application of mesh-free analysis of a bone-implant system for evaluation of performance of a bone-implant system for an implant implanted within the bone structure at an anatomical site, said method comprising (i) receiving a set of bone structure data set, wherein set of bone structure data includes data indicative of the bone structure at an anatomical site; (ii) inputting an implant data set and inputting the position of the implant data set, wherein the implant is selected based upon the biomechanical requirements for the anatomical site and the position and of the implant data set is indicative of the position of the implant with respect to the anatomical site, wherein implant data set includes data representative of the geometry and materials properties of the implant; (iii) creating a bone-implant model, wherein said bone implant-model includes a mesh-free model of trabecular bone at the anatomical site wherein the bone-implant model is

Abstract: Devices and methods for the removal of bone implant tips from within a bony structure in a body. The device or method includes a shaft with an internal grasping feature capable of being inserted while remaining in an un-expanded, un-deployed state. This permits a surgeon or operator to insert the device while in a small profile state, avoiding or reducing damage to adjacent bone tissue during insertion. Upon insertion of the shaft to the proper position within a patient's bone, the grasping feature may then be expanded or deployed from the distal end of the shaft by a surgeon or operator using an actuator in a handle attached to the proximal end of the shaft. Following deployment, the grasping feature may be used to manipulate and/or remove a bone implant tip from a patient's bone tissue. Embodiments of the grasping feature include one or more hooks, wires, articulating fingers, and/or net-based designs formed of metal, polymer, composite, or a combination thereof.

Abstract: Compositions containing strontium fortified calcium nanoparticles and/or microparticles, and methods of making and using thereof are described herein. The strontium fortified calcium compounds contain calcium ions, calcium atoms, strontium ions, strontium atoms, and combinations thereof and one or more anions. Exemplary anions include, but are not limited to, citrate, phosphate, carbonate, and combinations thereof. The particles can be formulated for enteral or parenteral administration by incorporating the particles into a pharmaceutically carrier. The compositions can further contain one or more active agents useful for bone diseases or disorders, such as vitamin D, growth factors, and combinations thereof. The compositions can be used to treat or prevent one or more bone diseases or disorders of the bone, such as osteoporosis. Alternatively, the particles can be coated onto a substrate, such as the surface of an implant.

Abstract: A composition for use as a bioactive bone cement having a powder component including strontium-containing hydroxy apatite and formulated to create a settable fluid substance when mixed with a liquid component. The liquid component includes a Bisphenol A diglycidylether dimethacrylate resin which when mixed with the powder component creates a bioactive bone cement. The bioactive bone cement can alternatively be in the form of a two paste component system in which a first paste component including strontium-containing hydroxy apatite, Bisphenol A diglycidylether dimethacrylate resin and a polymerization initiator is formulated to create a settable paste substance when mixed with a second paste component. The second paste component includes strontium-containing hydroxy apatite, Bisphenol A diglycidylether dimethacrylate resin, and a polymerization accelerator which when mixed together with the first paste component creates a bioactive bone cement.