Abstract: This disclosure provides compounds of Formula I, compositions comprising the same, and methods of using the same, including use in treating various diseases and conditions, e.g., those involving ferroptosis.

Abstract: Provided are compounds of Formula I, compositions comprising the same, and methods of using the same, including use in treating various diseases and conditions, e.g., those involving ferroptosis.

Abstract: The invention provides a method and an apparatus for determining an integrated exploitation approach for a shale and adjacent oil reservoirs. The method includes: determining a thickness of an effective shale, a top effective boundary and a bottom effective boundary of adjacent effective oil reservoirs; determining a maximum seepage radius of each of the adjacent effective oil reservoirs to the effective shale; determining a well pattern; determining a well completion approach; and determining a total number of perforation clusters of gas injection wells, a number of perforation clusters corresponding to each of the adjacent effective oil reservoirs, a gas injection amount per unit time of each of the perforation clusters, and a total gas injection amount per unit time of the gas injection wells. The effective shale is in communication with all the adjacent effective oil reservoirs by boring-through of a fluctuating horizontal well or a vertical well.

Abstract: The invention provides a method and an apparatus for determining an integrated exploitation approach for a shale and adjacent oil reservoirs. The method includes: determining a thickness of an effective shale, a top effective boundary and a bottom effective boundary of adjacent effective oil reservoirs; determining a maximum seepage radius of each of the adjacent effective oil reservoirs to the effective shale; determining a well pattern; determining a well completion approach; and determining a total number of perforation clusters of gas injection wells, a number of perforation clusters corresponding to each of the adjacent effective oil reservoirs, a gas injection amount per unit time of each of the perforation clusters, and a total gas injection amount per unit time of the gas injection wells. The effective shale is in communication with all the adjacent effective oil reservoirs by boring-through of a fluctuating horizontal well or a vertical well.

Abstract: Disclosed compounds, pharmaceutical compositions are used for inhibiting cathepsin C without inhibiting epidermal growth factor receptor (EGFR).