Patents by Inventor Weilan Zeng

Weilan Zeng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aggrecanase molecules
    Publication number: 20070128616
    Abstract: Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods of identifying and developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
    Type: Application
    Filed: May 22, 2006
    Publication date: June 7, 2007
    Applicant: Wyeth
    Inventors: Christopher Corcoran, Michael Agostino, Edward LaVallie, Carl Flannery, Weilan Zeng, Lisa Collins-Racie, Bethany Freeman
  • Modified ADAMTS4 molecules and method of use thereof
    Publication number: 20060228354
    Abstract: The present invention relates to modified ADAMTS4 proteins having improved stability comparing to the corresponding native, unmodified proteins. The modified ADAMTS4 proteins can be expressed and isolated in large quantities, thus allowing further characterization of the proteins, such as crystallographic and enzyme kinetic studies. The purified, stable proteins would also facilitate the production of anti-ADAMTS antibodies and the development of inhibitors to ADAMTS enzymes.
    Type: Application
    Filed: June 12, 2006
    Publication date: October 12, 2006
    Applicant: Wyeth
    Inventors: Christopher Corcoran, Carl Flannery, Weilan Zeng, Lisa Racie, Thomas McDonagh, Bethany Freeman, Katy Georgiadis, Edward LaVallie
  • Modified ADAMTS4 molecules and method of use thereof
    Patent number: 7118902
    Abstract: The present invention relates to modified ADAMTS4 proteins having improved stability comparing to the corresponding native, unmodified proteins. The modified ADAMTS4 proteins can be expressed and isolated in large quantities, thus allowing further characterization of the proteins, such as crystallographic and enzyme kinetic studies. The purified, stable proteins would also facilitate the production of anti-ADAMTS antibodies and the development of inhibitors to ADAMTS enzymes.
    Type: Grant
    Filed: July 29, 2003
    Date of Patent: October 10, 2006
    Assignee: Wyeth
    Inventors: Christopher John Corcoran, Carl R. Flannery, Weilan Zeng, Lisa A. Racie, Thomas McDonagh, Bethany A. Freeman, Katy E. Georgiadis, Edward R. LaVallie
  • Modified ADAMTS4 molecules and method of use thereof
    Publication number: 20040142863
    Abstract: The present invention relates to modified ADAMTS4 proteins having improved stability comparing to the corresponding native, unmodified proteins. The modified ADAMTS4 proteins can be expressed and isolated in large quantities, thus allowing further characterization of the proteins, such as crystallographic and enzyme kinetic studies. The purified, stable proteins would also facilitate the production of anti-ADAMTS antibodies and the development of inhibitors to ADAMTS enzymes.
    Type: Application
    Filed: July 29, 2003
    Publication date: July 22, 2004
    Applicant: WYETH
    Inventors: Christopher John Corcoran, Carl R. Flannery, Weilan Zeng, Lisa A. Racie, Thomas McDonagh, Bethany A. Freeman, Katy E. Georgiadis, Edward R. LaVallie
  • Aggrecanase molecules
    Publication number: 20040044194
    Abstract: Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods of identifying and developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
    Type: Application
    Filed: January 31, 2003
    Publication date: March 4, 2004
    Applicant: Wyeth
    Inventors: Christopher J. Corcoran, Michael J. Agostino, Edward R. Lavallie, Carl R. Flannery, Weilan Zeng, Lisa A. Collins-Racie, Bethany A. Freeman
  • Aggrecanase molecules
    Publication number: 20030228676
    Abstract: Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
    Type: Application
    Filed: December 30, 2002
    Publication date: December 11, 2003
    Inventors: Michael J. Agostino, Elizabeth DiBlasio, Edward R. Lavallie, Bethany A. Freeman, Lisa A. Racie, Weilan Zeng