Abstract: The present invention provides compositions and methods for stimulating an immune response using cationic lipids alone or in combination with antigens.

Abstract: Aspects concern service pricing device, comprising a receiving unit configured to receive service orders over a communication network from a plurality of customers requesting a service from a service provider in a predetermined area and in a time period; an allocation unit configured to determine a current allocation rate of received service orders among a plurality of service contractors and to allocate received service orders to the plurality of service contractors; and a pricing unit configured for determining a current price for a service order received in the time period for the predetermined area based on the current allocation rate of service orders and a predetermined allocation rate of service orders for the plurality of service contractors, and a notification unit configured to provide the current price of the service over the communication network to the plurality of customers and to the plurality of service contractors such that a service order for the predetermine area and in the time period is f

Abstract: A method for partitioning a geographic area, including: partitioning the geographic area into geographic units; for each respective geographic unit: determining, a central location of the respective geographic unit; determining, an aggregate demand location of the respective geographic unit based on pick-up locations in the respective geographic unit in a time period; determining, an aggregate supply location of the respective geographic unit based on provider locations when responding to requests having pick-up locations in the respective geographic unit in said time period; for each respective pair of geographic units, determining, among a plurality of the geographic units, a connection strength between the respective pair based on distance metrics between the respective pair, where the distance metrics are determined based on the central locations, the aggregate supply locations, and the aggregate demand locations of the respective pair in said time period; and assigning each respective geographic unit to

Abstract: The present invention provides compositions and methods for stimulating an immune response using cationic lipids alone or in combination with antigens.

Abstract: The present invention provides compositions and methods for stimulating an immune response using cationic lipids alone or in combination with antiigens.

Abstract: The present invention provides compositions and methods for stimulating an immune response using cationic lipids alone or in combination with antigens.

Abstract: The present invention provides compositions and methods for stimulating an immune response using cationic lipids alone or in combination with antigens.

Abstract: The present invention is directed to cationic lipid for the delivery of oligonucleotides and methods of modulating an expression of a targeted gene using the nanoparticle compositions. In particular, the invention relates to cholesterol and its derivatives having multiple positively charged moieties via branching spacers, and nanoparticle compositions of oligonucleotides encapsulated in a mixture of a cationic lipid, a fusogenic lipid and a PEG lipid.

Abstract: The present invention relates to polymer conjugated releasable lipids and nanoparticle compositions containing the same for the delivery of nucleic acids and methods of modulating gene expression using the same. In particular, this invention relates to releasable polymeric lipids containing an acid-labile linker based on a ketal or acetal-containing linker, or an imine-containing linker.

Abstract: The present invention is directed to releasable cationic lipids and nanoparticle compositions for the delivery of nucleic acids and methods of modulating an expression of a target gene using the same. In particular, the invention relates to cationic lipids including an acid labile linker, and nanoparticle compositions containing the same.

Abstract: The present invention relates to releasable fusogenic lipids and nanoparticle compositions containing the same for the delivery of oligonucleotides and methods of modulating gene expression using the same. In particular, this invention relates to releasable fusogenic lipids containing an imine linker and a zwitterionic moiety.

Abstract: The present invention provides compositions and methods for stimulating an immune response using cationic lipids alone or in combination with antigens.