Patents by Inventor Weiliam Chen
Weiliam Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10744099Abstract: A sterile pharmaceutical dosage form which comprises an ester capped lactide polymer, glycolide polymer or a lactide-glycolide copolymer hypercompressed with an active pharmaceutical ingredient wherein said sterile pharmaceutical dosage form has been sterilized with an electron beam and a method of preparing said sterile pharmaceutical dosage form.Type: GrantFiled: November 19, 2019Date of Patent: August 18, 2020Assignee: SUSTAINED NANO SYSTEMS LLCInventors: Barry M. Libin, Jeffrey M. Liebmann, Weiliam Chen
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Publication number: 20200085755Abstract: A sterile pharmaceutical dosage form which comprises an ester capped lactide polymer, glycolide polymer or a lactide-glycolide copolymer hypercompressed with an active pharmaceutical ingredient wherein said sterile pharmaceutical dosage form has been sterilized with an electron beam and a method of preparing said sterile pharmaceutical dosage form.Type: ApplicationFiled: November 19, 2019Publication date: March 19, 2020Inventors: Barry M. Libin, Jeffrey M. Liebmann, Weiliam Chen
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Patent number: 10500163Abstract: A sterile pharmaceutical dosage form which comprises an ester capped lactide polymer, glycolide polymer or a lactide-glycolide copolymer hypercompressed with an active pharmaceutical ingredient wherein said sterile pharmaceutical dosage form has been sterilized with an electron beam and a method of preparing said sterile pharmaceutical dosage form.Type: GrantFiled: July 10, 2018Date of Patent: December 10, 2019Assignee: SUSTAINED NANO SYSTEMS LLCInventors: Barry M. Libin, Jeffrey M. Liebmann, Weiliam Chen
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Patent number: 10406102Abstract: A pharmaceutical dosage form which comprises a lactide, glycolide or lactide-glycolide polymer, a block polymer of polyglycolide, trimethylene carbonate, poly-caprolactone, and polyethylene oxide that is combined with a peptide or protein therapeutic agent in the form of microparticles which are compressed using a pressure of 50,000 to 350,000 psi.Type: GrantFiled: July 10, 2018Date of Patent: September 10, 2019Assignee: SUSTAINED NANO SYSTEMS LLCInventors: Barry M. Libin, Jeffrey M. Liebmann, Weiliam Chen
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Publication number: 20190015347Abstract: A sterile pharmaceutical dosage form which comprises an ester capped lactide polymer, glycolide polymer or a lactide-glycolide copolymer hypercompressed with an active pharmaceutical ingredient wherein said sterile pharmaceutical dosage form has been sterilized with an electron beam and a method of preparing said sterile pharmaceutical dosage form.Type: ApplicationFiled: July 10, 2018Publication date: January 17, 2019Inventors: Barry M. Libin, Jeffrey M. Liebmann, Weiliam Chen
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Publication number: 20190015336Abstract: A pharmaceutical dosage form which comprises a lactide, glycolide or lactide-glycolide polymer, a block polymer of polyglycolide, trimethylene carbonate, poly-caprolactone, and polyethylene oxide that is combined with a peptide or protein therapeutic agent in the form of microparticles which are compressed using a pressure of 50,000 to 350,000 psi.Type: ApplicationFiled: July 10, 2018Publication date: January 17, 2019Inventors: Barry M. Libin, Jeffrey M. Liebmann, Weiliam Chen
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Publication number: 20180133363Abstract: A tissue sealant for use in surgical and medical procedures for sealing the tissues of a living mammal is provided. The tissue sealant comprises a hydrogel which is formed by gelation of a premix disposed on the tissue to be sealed. The premix comprises alkylated chitosan or a gelatin, and a polybasic carboxylic acid or an oxidized polysaccharide, in an aqueous medium. The premix can also include a dehydrating reagent, a carboxyl activating reagent, or both. A specific use of the tissue sealant is in the repair of the dura mater after brain surgery to prevent leakage of cerebrospinal fluid. The tissue sealant may include a therapeutic or protective agent such as an antibiotic or an anti-inflammatory drug.Type: ApplicationFiled: July 19, 2017Publication date: May 17, 2018Inventors: Weiliam Chen, John M. Abrahams
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Patent number: 9731044Abstract: A tissue sealant for use in surgical and medical procedures for sealing the tissues of a living mammal is provided. The tissue sealant comprises a hydrogel which is formed by gelation of a premix disposed on the tissue to be sealed. The premix comprises alkylated chitosan or a gelatin, and a polybasic carboxylic acid or an oxidized polysaccharide, in an aqueous medium. The premix can also include a dehydrating reagent, a carboxyl activating reagent, or both. A specific use of the tissue sealant is in the repair of the dura mater after brain surgery to prevent leakage of cerebrospinal fluid. The tissue sealant may include a therapeutic or protective agent such as an antibiotic or an anti-inflammatory drug.Type: GrantFiled: January 21, 2016Date of Patent: August 15, 2017Assignee: Endomedix, Inc.Inventors: Weiliam Chen, John M. Abrahams
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Publication number: 20160213811Abstract: A tissue sealant for use in surgical and medical procedures for sealing the tissues of a living mammal is provided. The tissue sealant comprises a hydrogel which is formed by gelation of a premix disposed on the tissue to be sealed. The premix comprises alkylated chitosan or a gelatin, and a polybasic carboxylic acid or an oxidized polysaccharide, in an aqueous medium. The premix can also include a dehydrating reagent, a carboxyl activating reagent, or both. A specific use of the tissue sealant is in the repair of the dura mater after brain surgery to prevent leakage of cerebrospinal fluid. The tissue sealant may include a therapeutic or protective agent such as an antibiotic or an anti-inflammatory drug.Type: ApplicationFiled: January 21, 2016Publication date: July 28, 2016Inventors: Weiliam Chen, John M. Abrahams
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Patent number: 9259434Abstract: A tissue sealant for use in surgical and medical procedures for sealing the tissues of a living mammal is provided. The tissue sealant comprises a hydrogel which is formed by gelation of a premix disposed on the tissue to be sealed. The premix comprises alkylated chitosan or a gelatin, and a polybasic carboxylic acid or an oxidized polysaccharide, in an aqueous medium. The premix can also include a dehydrating reagent, a carboxyl activating reagent, or both. A specific use of the tissue sealant is in the repair of the dura mater after brain surgery to prevent leakage of cerebrospinal fluid. The tissue sealant may include a therapeutic or protective agent such as an antibiotic or an anti-inflammatory drug.Type: GrantFiled: July 16, 2013Date of Patent: February 16, 2016Assignee: Endomedix, Inc.Inventors: Weiliam Chen, John M. Abrahams
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Publication number: 20140107065Abstract: A tissue sealant for use in surgical and medical procedures for sealing the tissues of a living mammal is provided. The tissue sealant comprises a hydrogel which is formed by gelation of a premix disposed on the tissue to be sealed. The premix comprises alkylated chitosan or a gelatin, and a polybasic carboxylic acid or an oxidized polysaccharide, in an aqueous medium. The premix can also include a dehydrating reagent, a carboxyl activating reagent, or both. A specific use of the tissue sealant is in the repair of the dura mater after brain surgery to prevent leakage of cerebrospinal fluid. The tissue sealant may include a therapeutic or protective agent such as an antibiotic or an anti-inflammatory drug.Type: ApplicationFiled: July 16, 2013Publication date: April 17, 2014Inventors: Weiliam Chen, John M. Abrahams
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Patent number: 8513217Abstract: A tissue sealant for use in surgical and medical procedures for sealing the tissues of a living mammal is provided. The tissue sealant comprises a hydrogel which is formed by gelation of a premix disposed on the tissue to be sealed. The premix comprises alkylated chitosan or a gelatin, and a polybasic carboxylic acid or an oxidized polysaccharide, in an aqueous medium. The premix can also include a dehydrating reagent, a carboxyl activating reagent, or both. A specific use of the tissue sealant is in the repair of the dura mater after brain surgery to prevent leakage of cerebrospinal fluid. The tissue sealant may include a therapeutic or protective agent such as an antibiotic or an anti-inflammatory drug.Type: GrantFiled: September 15, 2010Date of Patent: August 20, 2013Assignee: Endomedix, Inc.Inventors: Weiliam Chen, John M. Abrahams
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Patent number: 8071119Abstract: A dispensing device having a polymer which is combined with a therapeutic agent in the form of a microparticle or nanoparticle which is “hyper-compressed” to form a controlled release dispensing device and methods of locally administering a therapeutic agent using said microparticles.Type: GrantFiled: April 23, 2009Date of Patent: December 6, 2011Assignee: Sustained Nano Systems LLCInventors: Barry M. Libin, Jeffrey M. Liebmann, Weiliam Chen
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Publication number: 20110002999Abstract: A tissue sealant for use in surgical and medical procedures for sealing the tissues of a living mammal is provided. The tissue sealant comprises a hydrogel which is formed by gelation of a premix disposed on the tissue to be sealed. The premix comprises alkylated chitosan or a gelatin, and a polybasic carboxylic acid or an oxidized polysaccharide, in an aqueous medium. The premix can also include a dehydrating reagent, a carboxyl activating reagent, or both. A specific use of the tissue sealant is in the repair of the dura mater after brain surgery to prevent leakage of cerebrospinal fluid. The tissue sealant may include a therapeutic or protective agent such as an antibiotic or an anti-inflammatory drug.Type: ApplicationFiled: September 15, 2010Publication date: January 6, 2011Inventors: Weiliam Chen, John M. Abrahams
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Patent number: 7854923Abstract: A tissue sealant for use in surgical and medical procedures for sealing the tissues of a living mammal is provided. The tissue sealant comprises a hydrogel which is formed by gelation of a premix disposed on the tissue to be sealed. The premix comprises alkylated chitosan or a gelatin, and a polybasic carboxylic acid or an oxidized polysaccharide, in an aqueous medium. The premix can also include a dehydrating reagent, a carboxyl activating reagent, or both. A specific use of the tissue sealant is in the repair of the dura mater after brain surgery to prevent leakage of cerebrospinal fluid. The tissue sealant may include a therapeutic or protective agent such as an antibiotic or an anti-inflammatory drug.Type: GrantFiled: September 8, 2006Date of Patent: December 21, 2010Assignee: Endomedix, Inc.Inventors: Weiliam Chen, John M. Abrahams
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Publication number: 20100233267Abstract: The present invention features a composite hydrogel for use as soft tissue substitutes and transitional three-dimensional support structures.Type: ApplicationFiled: February 1, 2008Publication date: September 16, 2010Applicant: The Research Foundation of State University of New YorkInventors: Weiliam Chen, Lihui Weng, Hui Pan
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Patent number: 7763268Abstract: The present invention features dual network hydrogels that possess the structural, mechanical, and biological properties required of load bearing three-dimensional support structures.Type: GrantFiled: January 16, 2009Date of Patent: July 27, 2010Assignee: The Research Foundation of State University of New YorkInventors: Weiliam Chen, Lihui Weng
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Publication number: 20100178346Abstract: The present invention relates to materials comprising hyaluronic acid for replacement or augmentation of the nucleus pulposus The materials have a Poisson's ratio of 0.40 to 0.80 based on that of the human nucleus pulposus.Type: ApplicationFiled: February 1, 2008Publication date: July 15, 2010Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Neil R. Malhotra, Weiliam Chen, Dawn M. Elliott
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Publication number: 20100173000Abstract: A dispensing device having a polymer which is combined with a therapeutic agent in the form of a microparticle or nanoparticle which is “hyper-compressed” to form a controlled release dispensing device and methods of locally administering a therapeutic agent using said microparticles.Type: ApplicationFiled: November 25, 2009Publication date: July 8, 2010Applicant: SUSTAINED NANO SYSTEMS LLCInventors: Barry M. Libin, Jeffrey M. Liebmann, Weiliam Chen
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Publication number: 20100029789Abstract: The present invention features dual network hydrogels that possess the structural, mechanical, and biological properties required of load bearing three-dimensional support structures.Type: ApplicationFiled: January 16, 2009Publication date: February 4, 2010Inventors: Weiliam Chen, Lihui Weng