Abstract: Disclosed are a peptide compound and an application thereof, and a composition containing the peptide compound. The present invention provides a peptide compound YA-156, and a pharmaceutically acceptable salt, a tautomer, a solvate, a crystal form or a prodrug thereof. The compound has good stability and good activity for Kiss1R.

Abstract: A compound, as represented by formula I, as a TLR7 agonist, a method for preparing the compound, and the use of the compound in treating diseases mediated by the TLR7 agonist are provided. Studies on the activity of a human-derived receptor, a TLR7 agonist, show that compounds have a strong agonistic effect on the human-derived receptor, TLR7, and can be used as a foreground compound for treating diseases mediated by the TLR7 agonist.

Abstract: A device may store first data structures that include first data identifying computing resources provided at an edge of a network for a computing environment. The device may store second data structures that include second data identifying aggregations of portions of the first data, and may store a third data structure that includes third data identifying an aggregation of the second data. The device may receive, from a first client device, client data identifying an address and resources associated with the first client device, and may update a first data structure based on the client data. The device may update a second data structure based on updating the first data structure, and may update the third data structure based on updating the second data structure. The device may provide a notification indicating that the first client device has been added as a computing resource for the computing environment.

Abstract: A video encoding device (e.g., a wireless transmit/receive unit (WTRU)) may transmit an encoded frame with a frame sequence number using a transmission protocol. The video encoding device, an application on the video encoding device, and/or a protocol layer on the encoding device may detect a packet loss by receiving an error notification. The packet loss may be detected at the MAC layer. The packet loss may be signaled using spoofed packets, such as a spoofed NAM packet, a spoofed XR packet, or a spoofed ACK packet. A lost packet may be retransmitted at the MAC layer (e.g., by the encoding device or another device on the wireless path). Packet loss detection may be performed in uplink operations and/or downlink operations, and/or may be performed in video gaining applications via the cloud. The video encoding device may generate and send a second encoded frame based on the error notification.

Abstract: Disclosed are a peptide compound and an application thereof, and a composition containing the peptide compound. The present invention provides a peptide compound represented by compound 3, and a pharmaceutically acceptable salt, a tautomer, a solvate, a crystal form or a prodrug thereof. The compound has good stability and good activity for Kiss1R.

Abstract: The present disclosure discloses a preparation method of a multi-functional marine engineering alloy. Through the coupling of a multi-principal alloy structure, structural entropy, and temperature and powder metallurgy and heat treatment, mutual solubility between elements and free energy of an alloy system are regulated, Cu grain boundary segregation is eliminated, and uniform and dispersed nano-precipitation of the anti-fouling element Cu in corrosion-resistant and high-plasticity multi-principal alloys is realized. The preparation method is simple and controllable to operate, and the prepared material has plasticity higher than 75%, high yield strength, excellent corrosion resistance and anti-fouling property, and has important application prospects in the field of marine engineering.

Abstract: A network device in a Multi-Access Edge Computing (MEC) cluster is configured to: receive, from a wireless station, information associated with a User Equipment (UE) device that is wirelessly attached to a network through the wireless station and estimate a first time interval to complete a task for the UE device based on the information. If the first time interval is less than a threshold time interval, the processor is to: signal, through the wireless station, to the UE device to be in a connected state; execute the task; and send a result of the execution, through the wireless station, to the UE device.

Abstract: A device obtains previously created data content. The device unmasks and extracts one or more chain of custody blocks stored in association with the data content. The one or more chain of custody blocks includes chain of custody data identifying who, when, where, and, with what hardware and/or software, created or edited the data content. The device analyzes the one or more chain of custody blocks and validates an origination of the data content based on the analysis of the one or more chain of custody blocks.

Abstract: The present disclosure discloses a preparation method of a multi-functional marine engineering alloy. Through the coupling of a multi-principal alloy structure, structural entropy, and temperature and powder metallurgy and heat treatment, mutual solubility between elements and free energy of an alloy system are regulated, Cu grain boundary segregation is eliminated, and uniform and dispersed nano-precipitation of the anti-fouling element Cu in corrosion-resistant and high-plasticity multi-principal alloys is realized. The preparation method is simple and controllable to operate, and the prepared material has plasticity higher than 75%, high yield strength, excellent corrosion resistance and anti-fouling property, and has important application prospects in the field of marine engineering.

Abstract: A method may include receiving, at a wireless station, device capability information associated with a number of user equipment (UE) devices and determining, by the wireless station, uplink and downlink configurations for a number of carriers associated with the wireless station. The method may also include configuring uplink and downlink time slots for each of the carriers based on the determined uplink and downlink configurations and modifying the uplink and downlink configurations for at least some of the carriers over time based on data usage or congestion associated with the at least some of the plurality of carriers.

Abstract: The present invention discloses a hypocrellin derivative substituted both in a pen-position and in a 2-position by an amino, and a preparation method and use thereof. A general structural formula of the derivative is as represented by formulas I-a to I-d: The hypocrellin derivative substituted both in a peri-position and in a 2-position by an amino prepared in the present invention has a maximum absorption wavelength of 600-650 nm and a molar extinction coefficient reaching about 20000-40000 M?1cm?1. Compared with unmodified hypocrellin or hypocrellin having only a 2-position modified, an absorption spectrum of the derivative is significantly red-shifted and the molar extinction coefficient is greatly improved, and the derivative can efficiently produce reactive oxygen species such as singlet oxygen in a photosensitive condition.

Abstract: The present invention generally relates to a method for producing silicone hydrogel contact lenses having less optical defects or free of optical defects by subjecting the extraction tray for the formed silicone hydrogel contact lenses to a reciprocating lowering and raising motion thereof to obtain the silicone hydrogel contact lenses.

Abstract: Disclosed are a peptide compound and an application thereof, and a composition containing the peptide compound. The present invention provides a peptide compound represented by formula (1), and a pharmaceutically acceptable salt, a tautomer, a solvate, a crystal form or a prodrug thereof. The compound has good stability and good activity for Kiss1R.

Abstract: The invention provides a method producing contact lenses, comprising the step of: separating the mold into the male and female mold halves, with the silicone hydrogel contact lens adhered on one of the male and female mold halves; bring a shaped ultrasonic horn in direct contact with at least one area of a non-optical surface of the female mold half or the male mold half having the molded silicone hydrogel contact lens attached thereon; and applying a ultrasonic vibrational energy to the at least one area of the non-optical surface of the female mold half or the male mold half having the molded silicone hydrogel contact lens attached thereon so as to separate the molded silicone hydrogel contact lens from the mold half attached thereon.

Abstract: Disclosed are a peptide compound and an application thereof, and a composition containing the peptide compound. The present invention provides a peptide compound YA-156, and a pharmaceutically acceptable salt, a tautomer, a solvate, a crystal form or a prodrug thereof. The compound has good stability and good activity for Kiss1R.

Abstract: Disclosed are a peptide compound and an application thereof, and a composition containing the peptide compound. The present invention provides a peptide compound represented by compound 3, and a pharmaceutically acceptable salt, a tautomer, a solvate, a crystal form or a prodrug thereof. The compound has good stability and good activity for Kiss1R.

Abstract: The invention provides a method producing contact lenses, comprising the step of: separating the mold into the male and female mold halves, with the silicone hydrogel contact lens adhered on one of the male and female mold halves; bring a shaped ultrasonic horn in direct contact with at least one area of a non-optical surface of the female mold half or the male mold half having the molded silicone hydrogel contact lens attached thereon; and applying a ultrasonic vibrational energy to the at least one area of the non-optical surface of the female mold half or the male mold half having the molded silicone hydrogel contact lens attached thereon so as to separate the molded silicone hydrogel contact lens from the mold half attached thereon.

Abstract: An illustrative orchestration system is configured to provide, to a user equipment (UE) device communicatively coupled to a federation of compute clusters, cluster selection data for a subset of compute clusters from the federation of compute clusters. The cluster selection data is configured to facilitate the UE device in characterizing the compute clusters of the subset with respect to a service optimization policy. The orchestration system is further configured to receive, from the UE device, an orchestration request indicative of a compute cluster selected by the UE device based on the characterizing of the compute clusters of the subset. The orchestration system is configured to then orchestrate, in response to the orchestration request, fulfillment of a service request to be performed by the selected compute cluster for the UE device. Corresponding methods, systems, and devices are also disclosed.

Abstract: Provided are a route evaluation method, an electronic device and a storage medium. The method includes: acquiring target truth value data on user behaviors between a first to-be-evaluated location and a second to-be-evaluated location and collected by a route planning client, where at least one to-be-evaluated route is included between the first to-be-evaluated location and the second to-be-evaluated location; determining a target reference route between the first to-be-evaluated location and the second to-be-evaluated location according to the target truth value data on user behaviors; and evaluating the at least one to-be-evaluated route according to the target reference route. Therefore, the labor cost of route evaluation can be reduced and the accuracy and efficiency of the route evaluation can be improved.

Abstract: An exemplary multi-access edge computing (MEC) orchestration system obtains an operation parameter of a multi-client application that is to execute on a MEC server to be selected from a set of MEC servers located at a first set of locations within a coverage area of a provider network. When executing, the multi-client application serves respective client applications of a set of client devices located at a second set of locations within the coverage area. Based on the operation parameter, the MEC orchestration system identifies a candidate subset of MEC servers from the set of MEC servers and directs the set of client devices to test and report performance capabilities of the MEC servers in the candidate subset. Based on the reported performance capabilities, the MEC orchestration system selects, from the candidate subset of MEC servers, a particular MEC server on which the multi-client application is to execute.