Abstract: The present invention provides a mesothelin binding molecule, comprising an anti-mesothelin single domain antibody. Complementarity determining regions (CDR) of the single domain antibody comprise CDR1 shown in SEQ ID NO: 1, CDR2 shown in SEQ ID NO: 2, and CDR3 shown in SEQ ID NO: 3.

Abstract: Disclosed in the present invention is a nanobody, comprising a heavy chain variable region containing CDR1, CDR2 and/or CDR3, and having the function of recognizing and binding to BCMA. Reference can be made to the text for specific CDR sequences. Also disclosed in the present invention are a BCMA binding molecule, a composition comprising the nanobody or BCMA binding molecule, a BCMA detection agent, and an application of the nanobody, the BCMA binding molecule, or the composition in preparation of a drug for treating a BCMA related disease. The nanobody, BCMA binding molecule, and composition in the present invention can recognize and bind to BCMA, and have potential utility for treatment of BCMA related diseases.

Abstract: The present invention provides high affinity anti-CD40 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of cancer and other diseases.

Abstract: The present invention provides high affinity anti-CD40 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of cancer and other diseases.

Abstract: A measurement circuit and a measurement method for measuring and updating a voltage resolution of an electronic atomizer circuit are provided. In the measurement circuit, a comparison unit is configured to compare a first preset value and a second preset value to obtain a voltage difference, an accumulation and subtraction unit is configured to perform counting according to a comparison result, and a control unit is configured to adjust the voltage difference between two compared voltage input terminals, thereby calculating a voltage resolution of the control unit, avoiding the impact of the actual error of the first constant current source and the unit resistor on the actual voltage resolution, and ensuring the measurement accuracy. In addition, an accurate to-be-measured voltage is calculated, and a measurement value of the to-be-measured voltage is corrected, to ensure the high measurement accuracy of the to-be-measured voltage and the output power.

Abstract: A method for generating a plurality of diverse camelid antibodies to cover functional epitopes of the target with high-resolution. Also provided is a method for generating camelid antibodies.

Abstract: The present invention provides a measurement circuit and a measurement method. In the measurement circuit, a comparison unit is configured to compare a first preset value and a second preset value to obtain a voltage difference, an accumulation and subtraction unit is configured to perform counting according to a comparison result, and a control unit is configured to adjust the voltage difference between two compared voltage input terminals, thereby calculating a voltage resolution of the control unit, avoiding the impact of the actual error of the first constant current source and the unit resistor on the actual voltage resolution, and ensuring the measurement accuracy. In addition, an accurate to-be-measured voltage is calculated, and a measurement value of the to-be-measured voltage is corrected, to ensure the high measurement accuracy of the to-be-measured voltage and the output power.

Abstract: The present invention provides high affinity anti-CD40 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of cancer and other diseases.

Abstract: The present invention provides high affinity anti-CD40 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of cancer and other diseases.

Abstract: Disclosed is a postoperative functional exerciser for frozen shoulder. The exerciser includes a hand push rod (1) and a restrictive band (2) for restricting the elbow. The hand push rod (1) comprises a wristband (11) and a push rod (12). One end of the push rod (12) is connected with the wristband (11). When the hand push rod (1) and the restrictive band (2) are in operation, a part of the restrictive band (2) winds around the elbow joint of an affected arm, the other part winds around a waist buckle (3) at a waist portion of the restrictive band (2) on a side opposite to the affected arm, and the wristband (11) is sleeved on the wrist of the affected arm. The upper arm is tied to the body by means of the restrictive band (2).

Abstract: The present invention provides high affinity anti-CD40 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of cancer and other diseases.

Abstract: Provided herein, inter alia, is a method for producing an enriched population of antigen-specific plasma cells. In some embodiments, the method may comprise: (a) obtaining a sample of cells from an animal that has been immunized by an antigen, wherein the sample comprises B cells; (b) enriching for a population of antigen-specific B cells that comprise cell surface antibodies that are specific for the antigen by: i. contacting at least 105 of the cells in said sample, en masse, with the antigen or a portion thereof; and ii. isolating cells that bind to the antigen or portion thereof; and (c) activating the enriched B cells, en masse, in the presence of the antigen or portion thereof, to produce the enriched population of antigen-specific plasma cells.

Abstract: The present invention provides anti-RANKL monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of rheumatoid arthritis and other diseases.

Abstract: The invention provides a rabbit-derived immortal B-lymphocyte capable of fusion with a rabbit splenocyte to produce a hybrid cell that produces an antibody. The immortal B-lymphocyte does not detectably express endogenous immunoglobulin heavy chain and may contain, in certain embodiments, an altered immunoglobulin heavy chain-encoding gene. A hybridoma resulting from fusion between the subject immortal B-lymphocyte and a rabbit antibody-producing cell is provided, as is a method of using that hybridoma to produce an antibody. The subject invention finds use in a variety of different diagnostic, therapeutic and research applications.

Abstract: The present invention provides anti-RANKL monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of rheumatoid arthritis and other diseases.

Abstract: Disclosed is a postoperative functional exerciser for frozen shoulder. The exerciser includes a hand push rod (1) and a restrictive band (2) for restricting the elbow. The hand push rod (1) comprises a wristband (11) and a push rod (12). One end of the push rod (12) is connected with the wristband (11). When the hand push rod (1) and the restrictive band (2) are in operation, a part of the restrictive band (2) winds around the elbow joint of an affected arm, the other part winds around a waist buckle (3) at a waist portion of the restrictive band (2) on a side opposite to the affected arm, and the wristband (11) is sleeved on the wrist of the affected arm. The upper arm is tied to the body by means of the restrictive band (2).

Abstract: The present invention provides high affinity anti-CD40 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of cancer and other diseases.

Abstract: Provided herein, inter alia, is a method for producing an enriched population of antigen-specific plasma cells. In some embodiments, the method may comprise: (a) obtaining a sample of cells from an animal that has been immunized by an antigen, wherein the sample comprises B cells; (b) enriching for a population of antigen-specific B cells that comprise cell surface antibodies that are specific for the antigen by: i. contacting at least 105 of the cells in said sample, en masse, with the antigen or a portion thereof; and ii. isolating cells that bind to the antigen or portion thereof; and (c) activating the enriched B cells, en masse, in the presence of the antigen or portion thereof, to produce the enriched population of antigen-specific plasma cells.

Abstract: The present invention provides high affinity anti-CD40 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of cancer and other diseases.

Abstract: The present invention provides high affinity anti-CD40 monoclonal antibodies and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of cancer and other diseases.