Abstract: The present invention relates to methods and pharmaceutical compositions for reducing arterial stiffness in a human patient showing at least one symptom selected from increased pulse wave velocity (PWV) and increased pulse pressure (PP) comprising administration to said patient of a therapeutically effective amount or a prophylactically effective amount of a combination of a therapeutic agent blocking the angiotensin receptor and a therapeutic agent inhibiting the NEP enzyme, in particular of a combination of sacubitril or a pharmaceutically acceptable salt thereof and valsartan or a pharmaceutically acceptable salt thereof in a 1:1 molar ratio.

Abstract: The present invention relates to methods and pharmaceutical compositions for reducing arterial stiffness in a human patient showing at least one symptom selected from increased pulse wave velocity (PWV) and increased pulse pressure (PP) comprising administration to said patient of a therapeutically effective amount or a prophylactically effective amount of a combination of a therapeutic agent blocking the angiotensin receptor and a therapeutic agent inhibiting the NEP enzyme, in particular of a combination of sacubitril or a pharmaceutically acceptable salt thereof and valsartan or a pharmaceutically acceptable salt thereof in a 1:1 molar ratio.

Abstract: Disclosed is a resonant DC/DC converter, comprising a DC source unit, a power conversion unit, a control unit and an output rectification unit, wherein the power conversion unit comprises a resonance circuit and at least a phase-shift circuit, the phase-shift circuit comprises at least a pair of first switching elements S1, S2 and a phase-shift inductance La, one end of the phase-shift inductance is connected with the bridge node of the first switching element S1, S2, and the other end is coupled to the resonance circuit; the control unit drives each switching element of the power conversion unit, and the switching frequency and the phase shifting angle of the first switching element are calculated according to the feedback signals of the output rectification unit.

Abstract: Disclosed is a resonant DC/DC converter, comprising a DC source unit, a power conversion unit, a control unit and an output rectification unit, wherein the power conversion unit comprises a resonance circuit and at least a phase-shift circuit, the phase-shift circuit comprises at least a pair of first switching elements S1, S2 and a phase-shift inductance La, one end of the phase-shift inductance is connected with the bridge node of the first switching element S1, S2, and the other end is coupled to the resonance circuit; the control unit drives each switching element of the power conversion unit, and the switching frequency and the phase shifting angle of the first switching element are calculated according to the feedback signals of the output rectification unit.

Abstract: This invention provides methods of treating an abnormality that is linked to the activity of the mammalian SNORF138 receptor, as well as methods of determining binding of compounds to the mammalian SNORF138 receptor, methods of identifying agonists and antagonists of the SNORF138 receptor, and agonists and antagonists so identified.