Abstract: The invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially KRAS G12C inhibitors. The present invention provides a direct enantioselective chemical manufacturing method of making Compound A, or a pharmaceutically acceptable hydrate or solvent thereof: (I). The invention provides a process for preparing Intermediate B6* comprising reacting Intermediate B4* with Intermediate B5* in an atroposelective coupling reaction, using a chiral catalyst.

Abstract: A device of regulating a melting speed of an aluminum alloy smelting furnace burner. The device includes: a natural-gas flow-rate regulating assembly, an air flow regulating assembly; a natural gas burner, connected to the natural-gas flow-rate regulating assembly and the air flow regulating assembly and mounted in a melting zone of the melting furnace to melt aluminum alloy into an aluminum liquid; a scum filtration assembly, including a ceramic tube connected to a ceramic filter cylinder, a foam ceramic filter plate being merged in an aluminum liquid thermal-insulation pool; a rangefinder, mounted above the scum filter assembly; a controller for obtaining weights of the aluminum liquid corresponding to two adjacent time points, obtaining the actual melting speed according to a difference in the weights, and regulating the flow rate of the natural gas and the air flow to adjust the actual melting speed to reach a target melting speed.

Abstract: A gas water heater includes a bottom housing having an opening, a burner mounted at the bottom housing, and a cover plate assembly mounted at the bottom housing and covering the opening. The cover plate assembly includes a first cover plate and a second cover plate. The second cover plate is located between the burner and the first cover plate. The cover plate assembly has an air inlet channel located between the first cover plate and the second cover plate. The first cover plate has a first flow inlet in communication with the air inlet channel. The second cover plate has a second flow inlet distant from the first flow inlet, and in communication with the air inlet channel and an air inlet of the burner.

Abstract: A vision-based enhanced omni-directional defect detection method is provided. The method includes: performing posture adjustment on equipment, changing an equipment angle and a transmission speed, acquiring a multi-angle detection picture, and performing information fusion and classification. By means of the method, the influence of natural and human factors is solved, the problem of missing detection is solved by adoption of defect feature enhancement, and the part detection accuracy is improved.

Abstract: A data mining-based method for real-time production quality prediction of aluminum alloy casting, includes: (1) based on mold flow analysis results, installing sensors on a casting mold; wherein the sensors include at least one temperature sensor, at least one pressure sensor, at least one contact sensor, and a multi-functional gas sensor; (2) during casting production, real-time collecting temperatures, pressures, and contact times of the aluminum liquid at a plurality of locations of the casting mold, and pressure, composition, humidity, and temperature of gas in a mold cavity, by the installed sensors, for constructing an aluminum alloy casting process parameter set; and (3) inputting the process parameter set to a production quality prediction model; wherein the production quality prediction model is used to judge whether the production quality is qualified, which is obtained by mining a relationship between history casting process parameters and casting quality data.

Abstract: An apparatus for treating tinnitus through stimulating multiple acupoints with a multi-electrode electric pulse. A control terminal controls a first MCU micro-control module and the second MCU micro-control module to allow the second MCU micro-control module to output a variety of different pulse signals, and the different pulse signals are respectively output to an electric-pulse output circuit and an electric-pulse conversion circuit. The pulse signal output to the electric-pulse output circuit is a carrier signal. The pulse signal output to the electric-pulse conversion circuit is converted to a modulating wave by the electric-pulse conversion circuit. The modulating wave and the carrier signal are both output to the electrical-pulse output circuit. After a modulation, a transcutaneous electric-pulse stimulation signal is output by an output port, and is transmitted to an electrode sheet attached to the corresponding acupoint on human body through an electrode wire to stimulate the acupoint.

Abstract: The present disclosure relates to a performance testing device applicable to a metal fuel cell, and belongs to the field of metal fuel cells. Self-adaptive clamping equipment can be used for autonomously positioning and clamping galvanic piles with different sizes and shapes, and can be self-adaptively fixed according to the shapes. Sealing performance testing equipment is used for testing the sealing performance of the metal fuel cell through a testing pool. Discharge performance testing equipment is used for testing the discharge performance of the metal fuel cell. According to the performance testing device, two performances of sealing and discharging can be tested at the same time, perfusion of different electrolytes and measurement of galvanic piles composed of different numbers of single cells with different sizes can be realized, and the compatibility requirement of large-batch and multi-type cells delivered from a factory is met.

Abstract: Technologies are described herein for denormalizing data instances. Schemas for data instances are embedded with annotations indicating how the denormalization is to be performed. Based on the annotations, one or more sub per object indexes (“sub POIs”) can be generated for each data instance and stored. The sub POIs can include a target sub POI containing data from the data instance, and at least one source sub POI containing data from another data instance, if the data instance depends on the other data instance. Data instance updates can be performed by identifying sub POIs that are related to the updated data instance in storage, and updating the related sub POIs according to the update to the data instance. The sub POIs can be sent to an indexing engine to generate an index for a search engine to facilitate searches on the data instances.

Abstract: An apparatus for treating tinnitus through stimulating multiple acupoints with a multi-electrode electric pulse. A control terminal controls a first MCU micro-control module and the second MCU micro-control module to allow the second MCU micro-control module to output a variety of different pulse signals, and the different pulse signals are respectively output to an electric-pulse output circuit and an electric-pulse conversion circuit. The pulse signal output to the electric-pulse output circuit is a carrier signal. The pulse signal output to the electric-pulse conversion circuit is converted to a modulating wave by the electric-pulse conversion circuit. The modulating wave and the carrier signal are both output to the electrical-pulse output circuit. After a modulation, a transcutaneous electric-pulse stimulation signal is output by an output port, and is transmitted to an electrode sheet attached to the corresponding acupoint on human body through an electrode wire to stimulate the acupoint.

Abstract: A device for strengthening a straight pipe, including a first positioning mold, a second positioning mold, a split mold, a rounding mold, a first cavity and a second cavity. A method for strengthening a straight pipe is further provided. The split mold is adjusted to position the pipe. The pipe is inserted into the first and second positioning molds. First and second sealing rings are arranged in an inner cavity of the pipe. Hydraulic oil is injected into the first cavity to expand the pipe to perform an expanding deformation. When the hydraulic oil is unloaded, the split mold moves towards an axis of the first positioning mold to perform a reducing deformation. After the expanding and reducing deformations, the pipe is transported into the rounding mold, and hydraulic oil is injected into the second cavity to expand the pipe to perform the rounding.

Abstract: A device for strengthening a straight pipe, including a first positioning mold, a second positioning mold, a split mold, a rounding mold, a first cavity and a second cavity. A method for strengthening a straight pipe is further provided. The split mold is adjusted to position the pipe. The pipe is inserted into the first and second positioning molds. First and second sealing rings are arranged in an inner cavity of the pipe. Hydraulic oil is injected into the first cavity to expand the pipe to perform an expanding deformation. When the hydraulic oil is unloaded, the split mold moves towards an axis of the first positioning mold to perform a reducing deformation. After the expanding and reducing deformations, the pipe is transported into the rounding mold, and hydraulic oil is injected into the second cavity to expand the pipe to perform the rounding.

Abstract: An input method editor (IME) provides a distributed platform architecture that enables associating multiple applications with the IME to provide extended functionalities. The presentations of the applications, such as skins, may be different from each other and that of the IME. The applications may be represented in a manifest file that is human-readable and editable. The IME collects multiple parameters relating to a user input into a host application including a query input by the user and a scenario of the host application, and selects one or more applications to provide candidates based on a score or ranking of the applications under the collected multiple parameters. Machine-learning may be used to improve the score or ranking. The candidates may include text candidates, rich candidates, and informative candidates.

Abstract: An input method editor (IME) configured to provide language assistance across a plurality of applications is disclosed. In one example, the IME is adapted for use by English-as-a-second-language (ESL) users. In a specific example, language assistance may be provided by first detecting a need to suggest a substitute word to a user who is typing within an application. The detection may be based on a probability that a current word is in error. If a need is detected, a suggestion may be obtained for the word, such as from a cloud linguistic service or from a local lexicon and language-model, if network connectivity is poor. Once obtained, the suggestion may be displayed to the user in a non-intrusive manner by user interface element(s). Interaction with the user allows the user to accept or reject the suggestion, and perform other functions, such as relocating user interface elements utilized by the display.

Abstract: Technologies are described herein for denormalizing data instances. Schemas for data instances are embedded with annotations indicating how the denormalization is to be performed. Based on the annotations, one or more sub per object indexes (“sub POIs”) can be generated for each data instance and stored. The sub POIs can include a target sub POI containing data from the data instance, and at least one source sub POI containing data from another data instance, if the data instance depends on the other data instance. Data instance updates can be performed by identifying sub POIs that are related to the updated data instance in storage, and updating the related sub POIs according to the update to the data instance. The sub POIs can be sent to an indexing engine to generate an index for a search engine to facilitate searches on the data instances.

Abstract: Technologies are described herein for denormalizing data instances. Schemas for data instances are embedded with annotations indicating how the denormalization is to be performed. Based on the annotations, one or more sub per object indexes (“sub POIs”) can be generated for each data instance and stored. The sub POIs can include a target sub POI containing data from the data instance, and at least one source sub POI containing data from another data instance, if the data instance depends on the other data instance. Data instance updates can be performed by identifying sub POIs that are related to the updated data instance in storage, and updating the related sub POIs according to the update to the data instance. The sub POIs can be sent to an indexing engine to generate an index for a search engine to facilitate searches on the data instances.

Abstract: An input method editor (IME) described herein couples scenarios of the input of the user with specific network services to offer more relevant and richer candidates for higher input productivity. Data relating to a computer application in which the input candidates are to be input and/or context relating to a user-submitted query is collected and analyzed to determine a scenario. The input candidates may include text candidates and rich candidates. The IME may select a scenario-tuned and type specific engine to identify the text candidates and/or rich candidates. The scenario-tuned text candidate engines leverage scenario-tuned language models and lexicons, and the scenario-tuned rich candidate engines leverage scenario-relevant web services, such as image, mapping, and video search, when available and appropriate.

Abstract: Some implementations provide techniques and arrangements for semantic lexicon based processing, such as in an input method editor. In some instances, a semantic label may be received that is to be defined for a semantic lexicon and at least a first term may be identified as a positive or negative example of the semantic label. In response, some examples may label at least a second term in the semantic lexicon with the semantic label based at least in part on the identification of the first term as a positive or negative example of the semantic label.

Abstract: An input method editor (IME) provides a distributed platform architecture that enables associating multiple applications with the IME to provide extended functionalities. The presentations of the applications, such as skins, may be different from each other and that of the IME. The applications may be represented in a manifest file that is human-readable and editable. The IME collects multiple parameters relating to a user input into a host application including a query input by the user and a scenario of the host application, and selects one or more applications to provide candidates based on a score or ranking of the applications under the collected multiple parameters. Machine-learning may be used to improve the score or ranking. The candidates may include text candidates, rich candidates, and informative candidates.

Abstract: Technologies are described herein for denormalizing data instances. Schemas for data instances are embedded with annotations indicating how the denormalization is to be performed. Based on the annotations, one or more sub per object indexes (“sub POIs”) can be generated for each data instance and stored. The sub POIs can include a target sub POI containing data from the data instance, and at least one source sub POI containing data from another data instance, if the data instance depends on the other data instance. Data instance updates can be performed by identifying sub POIs that are related to the updated data instance in storage, and updating the related sub POIs according to the update to the data instance. The sub POIs can be sent to an indexing engine to generate an index for a search engine to facilitate searches on the data instances.

Abstract: A WIFI device and an operating method and device of WIFI chips in a WIFI device are provided. In the operating method, an instruction indicating selection of an operation mode of a first WIFI chip and a second WIFI chip in a WIFI device is received (S202); the first WIFI chip is triggered to operate on a first frequency band and the second WIFI chip is triggered to operate on a second frequency band when the operation mode indicated by the instruction is a first mode (S204). The first WIFI chip supports the first frequency band and the second frequency band, and the second WIFI chip supports the second frequency band.