Patents by Inventor Weiping Shen

Weiping Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation and the use of ethoxy combretastatins and their prodrugs
    Patent number: 7838706
    Abstract: The invention disclosed a total synthesis process of novel ethoxy combretastatins and their prodrugs. Combretastatins are chemically modified by ethoxy substituted on the 4?-position of their B aryl ring and are converted to be their soluble prodrugs of phosphate or their inner salt of phosphorylcholine by modifying the hydroxyl on the 3?-position of their B aryl ring. Similarly, 3?-amino combretastatin is 4?-ethoxy chemically modified and further side chain of amino acid can be introduced to the amino to form soluble prodrug of amino acidamide. The structure of the said compound is showed as formula (I). Ethoxy combretastatins possess potent tubulin polymerization inhibitory activity and can be used for the treatment of inhibiting tumor or neovascular.
    Type: Grant
    Filed: May 16, 2007
    Date of Patent: November 23, 2010
    Assignee: Zhejiang Dade Pharmaceutical Group Co. Ltd
    Inventors: Weiping Shen, Jianping Wang, Jianguo Wang
  • Fluoroalkoxycombretastatin derivatives, method for producing the same and use thereof
    Patent number: 7786098
    Abstract: Combretastatin derivatives of formula (I), preparation and use thereof are disclosed, wherein: Rf is alkyl with 1-8 carbon atoms and 1-17 fluorine atoms, R is amino, substituted amino, hydroxyl, nitro, halo, alkyloxy, phosphate or amino acid side chain. Said derivatives have a capability to inhibit the polymerization of microtubules and are useful in treatment against tumor and neovascularization.
    Type: Grant
    Filed: November 22, 2006
    Date of Patent: August 31, 2010
    Assignee: Zhejiang Dade Pharmaceutical Group Co. Ltd.
    Inventors: Weiping Shen, Jianping Wang, Jianguo Wang, Hongmei Jin, Feng Qian, Fei Wang
  • PREPARATION AND THE USE OF ETHOXY COMBRETASTATINS AND THEIR PRODRUGS
    Publication number: 20090170956
    Abstract: The invention disclosed a total synthesis process of novel ethoxy combretastatins and their prodrugs. Combretastatins are chemically modified by ethoxy substituted on the 4?-position of their B aryl ring and are converted to be their soluble prodrugs of phosphate or their inner salt of phosphorylcholine by modifying the hydroxyl on the 3?-position of their B aryl ring. Similarly, 3?-amino combretastatin is 4?-ethoxy chemically modified and further side chain of amino acid can be introduced to the amino to form soluble prodrug of amino acidamide. The structure of the said compound is showed as formula (I). Ethoxy combretastatins possess potent tubulin polymerization inhibitory activity and can be used for the treatment of inhibiting tumor or neovascular.
    Type: Application
    Filed: May 16, 2007
    Publication date: July 2, 2009
    Applicant: Zhejiang Dade Pharmaceutical Group Co. Ltd
    Inventors: Weiping Shen, Jianping Wang, Jianguo Wang
  • Fluoroalkoxycombretastatin Derivatives, Method For Producing the Same and Use Thereof
    Publication number: 20080306027
    Abstract: Combretastatin derivatives of formula (I), preparation and use thereof are disclosed, wherein: Rf is alkyl with 1-8 carbon atoms and 1-17 fluorine atoms, R is amino, substituted amino, hydroxyl, nitro, halo, alkyloxy, phosphate or amino acid side chain. Said derivatives have a capability to inhibit the polymerization of microtubules and are useful in treatment against tumor and neovascularization.
    Type: Application
    Filed: November 22, 2006
    Publication date: December 11, 2008
    Applicant: Zhejiang Dade Pharmaceutical Group Co., Ltd.
    Inventors: Weiping Shen, Jianping Wang, Jianguo Wang, Feng Qian, Fei Wang, Hongmei Jin