Abstract: The disclosure provides a cartilage substitute, which includes at least one cartilage unit, the cartilage unit including: a base, including a subcutaneous layer portion forming contact friction with a corresponding skeleton, a deep layer area portion contacting with a target skeleton and an intermediate layer portion provided between the subcutaneous layer portion and the deep layer area portion. A fluid storage cavity is disposed in the subcutaneous layer portion. A first communicating passage is disposed in the subcutaneous layer portion. A second communicating passage is disposed in the intermediate layer portion, a third communicating passage is disposed in the deep layer area portion. The fluid storage cavity, the second communicating passage and the third communicating passage are disposed to gradually increase hardness of the subcutaneous layer portion, the intermediate layer portion and the deep layer area portion.

Abstract: Compositions and methods for eliciting an immune response in a subject against Vibrio cholerae are provided. The compositions include fusion proteins with one or more epitopes from Vibrio cholerae, nucleic acids and vectors encoding the fusion proteins, pharmaceutical compositions, immunogenic compositions, and vaccines. In examples, the methods include administering a disclosed composition to a subject, such as a human.

Abstract: Compositions and methods for eliciting an immune response in a subject (such as against Shigella) are provided. In examples, the compositions can include fusion proteins including one or more epitopes from Shigella or E. coli. In examples, the methods can include administering a disclosed fusion protein to a subject.

Abstract: A rare earth element containing zeolitic material having an AEI-type framework structure, the framework structure of the zeolitic material comprising SiO2 and X2O3, X being a trivalent element, wherein the zeolitic material contains one or more rare earth elements as counter-ions at the ion exchange sites of the framework structure, and wherein the zeolitic material is obtainable and/or obtained according to a process involving the hydrothermal treatment of the rare earth element containing zeolitic material at a temperature in the range of from 400 to 1,000° C. A coated monolith substrate comprising a rare earth element containing zeolitic material having an AEI-type framework structure, wherein the zeolitic material is supported on the monolith substrate. A process for the production of a coated monolith substrate comprising a rare earth element containing zeolitic material having an AEI-type framework structure.

Abstract: A composition containing recombinant collagen with repairing and soothing effects, eye cream containing the composition and preparation method thereof are provided. The composition contains the following raw materials in parts by weight: 1 to 10 parts of recombinant collagen, 1 to 10 parts of sodium hyaluronate, 1 to 5 parts of bifida ferment lysate, 1 to 15 parts of glucosylglycerol, 1 to 10 parts of bisabolol, 1 to 15 parts eight-treasure essence stock solution, and 1 to 15 parts of pink red plum rechecking essence. The composition features with good skin permeability, contributing to its significant effects on repairing skin barriers and relieving skin inflammation, as well as its advantages of low irritation and high safety. Thus, the composition is suitable for people with damaged eye skin and has good market application prospects.

Abstract: A process for the production of an aromatic compound which comprise reacting a mixture comprising ethylene and a furan compound over a zeolitic material having a BEA-type framework structure is described, wherein the zeolitic material having a BEA-type framework structure comprised in the catalyst is obtainable and/or obtained according to an organotemplate-free synthetic process.

Abstract: The present invention discloses a metal-ceramic composite joint prosthesis and applications and a manufacturing method thereof. The joint prosthesis comprises a metal body and a ceramic body, wherein the metal body is integrally formed and comprises a porous structure layer, a boundary layer and a root-like layer, the boundary layer is located between the porous structure layer and the root-like layer, the root-like layer comprises a plurality of root-like filament clusters connected to the boundary layer but not in contact with one another, each root-like filament cluster comprises a main root perpendicularly connected to the boundary layer and a plurality of fibrous roots connected to the lateral side of the main root, the fibrous roots extend obliquely towards the side away from the boundary layer, and the ceramic body covers the root-like filament clusters and is formed on the boundary layer.

Abstract: Provided herein are polypeptides comprising up to 9 antigenic elements of ETEC virulence determinants: 7 CFA adhesins [CFA/I, CFA/II (CS1, CS2, CS3), CFA/IV (CS4, CS5, CS6)] expressed by the most prevalent and virulent ETEC strains, and 2 toxins expressed by all ETEC strains, were genetically fused together for CFA-toxoid fusion with proteins (CFA/I/II/IV-STatoxoid-LTtoxoid). Methods for making these polypeptides and their use in the treatment of ETEC related disease are also provided.

Abstract: The present invention relates to a crystalline material having a framework structure comprising O and one or more tetravalent elements Y, and optionally comprising one or more trivalent elements X, wherein the crystalline material displays a crystallographic unit cell of the monoclinic space group C2, wherein the unit cell parameter a is in the range of from 14.5 to 20.5 ?, the M unit cell parameter b is in the range of from 14.5 to 20.5 ?, the unit cell parameter c in the range of from 11.5 to 17.5 ? and the unit cell parameter ? is in the range of from 109 to 118°, wherein the framework density is in the range of from 11 to 23 T-atoms/1000 ?3 wherein the framework structure comprises 12 membered rings, and wherein the framework structure displays a 2-dimensional channel e dimensionality of 12 membered ring channels. The present invention further relates to a process for the production of said material, as N well as to its use, in particular as a catalyst or catalyst component.

Abstract: The present invention relates to a process for the preparation of a zeolitic material SiO2 and X2O3 in its framework structure, wherein X stands for a trivalent element, wherein said process comprises interzeolitic conversion of a first zeolitic material comprising SiO2 and X2O3 in its framework structure, wherein the first zeolitic material has an FER-, TON-, MTT-, BEA-, MEL-, MWW-, MFS-, and/or MFI-type framework structure to a second zeolitic material comprising SiO2 and X2O3 in its framework structure, wherein the second zeolitic material obtained in (2) has a different type of framework structure than the first zeolitic material. Furthermore, the present invention relates to a zeolitic material per se as obtainable and/or obtained according to the inventive process and to its use, in particular as a molecular sieve, as an adsorbent, for ion-exchange, or as a catalyst and/or as a catalyst support.

Abstract: The present invention relates to a zeolitic material having the IWR type framework structure, wherein the zeolitic material comprises YO2 and X2O3 in its framework structure, wherein Y is a tetravalent element and X is a trivalent element, and wherein the framework structure of the zeolitic material comprises less than 5 weight-% weight-% of Ge calculated as GeO2 and based on 100 weight-% weight-% of YO2 contained in the framework structure, and less than 5 weight-% weight-% of B calculated as B2O3 and based on 100 weight-% weight-% of X2O3 contained in the framework structure. Further, the present invention relates to a process for preparing a zeo-litic material having the IWR type framework structure, wherein the zeolitic material comprises YO2 and X2O3 in its framework structure, wherein Y is a tetravalent element and X is a trivalent element.

Abstract: Provided herein are polypeptides comprising up to 9 antigenic elements of ETEC virulence determinants: 7 CFA adhesins [CFA/I, CFA/II (CS1, CS2, CS3), CFA/IV (CS4, CS5, CS6)] expressed by the most prevalent and virulent ETEC strains, and 2 toxins expressed by all ETEC strains, were genetically fused together for CFA-toxoid fusion with proteins (CFA/I/II/IV-STa-toxoid-LTtoxoid). Methods for making these polypeptides and their use in the treatment of ETEC related disease are also provided.

Abstract: The disclosure provides a meniscus substitute and a knee joint prosthesis with the meniscus substitute. The meniscus substitute includes: a base body, disposed on a tibial plateau or a tibial plateau prosthesis of a tibia; a polymer joint body, disposed on the base body; and a bone screw, disposed in the tibia in a penetration manner and connected with the base body.

Abstract: The disclosure provides an articular gasket prosthesis and an articular prosthesis with the articular gasket prosthesis. The articular gasket prosthesis includes an elastic gasket disposed between a first skeleton and second skeleton forming a joint, the elastic gasket including: an elastic matrix, having a first contact surface facing the first skeleton and a second contact surface facing the second skeleton; and multiple synovial fluid passages, distributed in the elastic matrix and communicating the first contact surface and the second contact surface, the multiple synovial fluid passages being disposed according to a predetermined manner to gradually increase hardness of the elastic matrix from a center to an edge and gradually decrease elasticity of the elastic matrix from the center to the edge.

Abstract: The disclosure provides an articular fossa prosthesis and an articular prosthesis with the articular fossa prosthesis. An outer cup of the articular fossa prosthesis is disposed in a target skeleton, a lining is disposed in the outer cup, an articular head structure may be movably disposed in the lining, a first communicating passage communicated with an articular capsule is disposed on the outer cup, a second communicating passage communicated with the articular capsule is disposed on the lining, and the first communicating passage is communicated with the second communicating passage to guide a synovial fluid to a contact surface between the lining and the articular head structure.

Abstract: The present invention relates to a rare earth element containing zeolitic material having a framework structure selected from the group consisting of AEI, AFT, AFV, AFX, AVL, CHA, EMT, GME, KFI, LEV, LTN, and SFW, including mixtures of two or more thereof, the framework structure of the zeolitic material comprising SiO2 and X2O3, wherein X stands for a trivalent element, wherein the zeolitic material displays an SiO2:X2O molar ratio in the range of from 2 to 20, and wherein the zeolitic material contains one or more rare earth elements as counter-ions at the ion exchange sites of the framework structure. Furthermore, the present invention relates to a process for the production of the inventive rare earth element containing zeolitic material as well as to the use of the inventive rare earth element containing zeolitic material.

Abstract: The present invention relates to a process for the production of a transition metal containing zeolite comprising expanding a layered silicate with a swelling agent and introducing the transition metal into the interlayer expanded silicate prior to calcination thereof for obtaining the transition metal containing zeolite. The present invention further relates to a zeolite containing transition metal nanoparticles as obtainable or obtained according to the inventive process, as well as to a zeolite containing nanoparticles per se. Finally the present invention relates to the use of a zeolite containing transition metal nanoparticles as obtainable or obtained according to the inventive process, as well as to the use of a zeolite containing nanoparticles per se.

Abstract: The disclosure provides an articular fossa prosthesis and an articular prosthesis with the articular fossa prosthesis. An outer cup of the articular fossa prosthesis is disposed in a target skeleton, a lining is disposed in the outer cup, an articular head structure may be movably disposed in the lining, a first communicating passage communicated with an articular capsule is disposed on the outer cup, a second communicating passage communicated with the articular capsule is disposed on the lining, and the first communicating passage is communicated with the second communicating passage to guide a synovial fluid to a contact surface between the lining and the articular head structure.

Abstract: The present invention discloses a metal-ceramic composite joint prosthesis and applications and a manufacturing method thereof. The joint prosthesis comprises a metal body and a ceramic body, wherein the metal body is integrally formed and comprises a porous structure layer, a boundary layer and a root-like layer, the boundary layer is located between the porous structure layer and the root-like layer, the root-like layer comprises a plurality of root-like filament clusters connected to the boundary layer but not in contact with one another, each root-like filament cluster comprises a main root perpendicularly connected to the boundary layer and a plurality of fibrous roots connected to the lateral side of the main root, the fibrous roots extend obliquely towards the side away from the boundary layer, and the ceramic body covers the root-like filament clusters and is formed on the boundary layer.