Abstract: A system using global and local-aware denoising framework for commonsense knowledge graph noise detection is provided. The system includes an input receiver, a triple encoder, a global noise detector, a local noise detector, and a comprehensive evaluation scorer. The triple encoder receives the CSKG information from the input receiver and extract semantic information from free-text formatted nodes in the CSKG information, so as to obtain structured triples. The global noise detector identifies high-frequency patterns through rule mining and uses a rule encoder to generalize learned rules and guide noise detection. The local noise detector utilizes the structured triples output by the triple encoder to aggregate neighboring triple information around both the head and tail nodes via graph networks. The comprehensive evaluation scorer provides a comprehensive score based on global noise detection and local noise detection, so as to indicate a noise level for the CSKG information.

Abstract: A focused ultrasound treatment system has: a focused ultrasound unit configured to emit focused ultrasound waves to a focal region to perform treatment; an ultrasound imaging unit configured to, after treatment emit imaging ultrasonic waves to an imaging region and receive corresponding echoes, and image a corresponding vascular blood flow image on the basis of the echo; a region planning and parameter adjustment unit configured to re-delineate a focal region on the basis of the vascular blood flow image and to re-adjust a treatment parameter of the focused ultrasound unit so as to be used to next treat the re-delineated focal region. The imaging region contains the focal region.

Abstract: An optical fiber with wide bandwidth and high gain in an O+E band and a regulation method thereof are disclosed. The optical fiber includes a core and a cladding (0). The core includes a first loose layer (1), a first core layer (2), a second loose layer (3), a second core layer (4) and an inner core (5) from outside to inside. The first loose layer (1) and the second loose layer (3) are made of a silica material doped with high-refractive-index GeO2 and P2O5. In the first core layer (2) and the second core layer (4), Al2O3, bismuth oxide and PbO are sequentially doped. The gain performance of the optical fiber is controlled by adjusting doping molar ratios of Al2O3, bismuth oxide and PbO. The co-doped silica optical fiber maintains fiber gains exceeding 15 dB in a wavelength range of 1260 to 1460 nm.

Abstract: A record of authorization including user information is received and appended to a blockchain. The record of authorization authorizes access by a third-party application to the user information for an access duration. The user information is encrypted by a group key and access duration is based on a change to the group key. The group key comprises a public/private key pair, and the access duration is implemented by an authorization group of nodes having the group key. The group key corresponds to either a valid group key at or near the start of the access duration, that enables decryption of a message in the record of authorization that includes the user information, or an incompatible group key at or after the end of the access duration, that does not enable decryption of the message in the record of authorization that includes the user information.

Abstract: A record of authorization including user information is received and appended to a blockchain. The record of authorization authorizes access by a third-party application to the user information for an access duration. The user information is encrypted by a group key and access duration is based on a change to the group key. The group key comprises a public/private key pair, and the access duration is implemented by an authorization group of nodes having the group key. The group key corresponds to either a valid group key at or near the start of the access duration, that enables decryption of a message in the record of authorization that includes the user information, or an incompatible group key at or after the end of the access duration, that does not enable decryption of the message in the record of authorization that includes the user information.

Abstract: A cyber-physical energy optimization control system for a hybrid electric vehicle includes an information layer which is configured to realize vehicle and road condition information collection, hybrid control unit (HCU) threshold optimization and threshold wireless update loading, and an optimized object plug-in hybrid electric bus (PHEB) as a physical layer.

Abstract: The invention provides a process for production of trans-dibenzoxenopyrrole compounds, in which reduction, leaving group conversion, hydrogenation and methylation are carried out in that order. The process of the invention allows trans-dibenzoxenopyrrole compounds to be produced by a simpler procedure than conventional processes. The invention further provides novel compounds obtained as intermediates in the process, and a process for their production.

Abstract: The present invention provides a process for producing an aromatic unsaturated compound of the formula (4) wherein Ar represents an optionally substituted aromatic group or an optionally substituted heteroaromatic group, and Y represents an electron withdrawing group, which comprises reacting (a) a compound of the formula (1) Ar—H??(1) wherein Ar has the same meaning as defined above with (b) a compound of the formula (2) wherein Y has the same meaning as defined above, and Z represents a lower alkoxy, or a compound of the formula (3) wherein Y and Z have the same meanings as defined above, in the presence of (c) an acid or a compound which generates a mineral acid by its hydrolysis.

Abstract: The invention provides a process for production of trans-dibenzoxenopyrrole compounds, in which reduction, leaving group conversion, hydrogenation and methylation are carried out in that order. The process of the invention allows trans-dibenzoxenopyrrole compounds to be produced by a simpler procedure than conventional processes. The invention further provides novel compounds obtained as intermediates in the process, and a process for their production.

Abstract: The invention provides a process for efficiently producing optically active mirtazapine. Specifically, a process for production of optically active mirtazapine wherein an RS mixture of mirtazapine is optically resolved with optically active tartaric acid in the presence of a solvent. More specifically, a process for production of optically active mirtazapine, characterized by making an RS mixture of mirtazapine contact with optically active tartaric acid in the presence of a solvent, and preferentially crystallizing the optically active mirtazapine salt. The solvent is preferably a mixed solvent consisting of a water-soluble organic solvent and water, and more preferably a mixed solvent consisting of a C1-3 alcohol and water.

Abstract: The present invention provides a process for producing an aromatic unsaturated compound of the formula (4) wherein Ar represents an optionally substituted aromatic group or an optionally substituted heteroaromatic group, and Y represents an electron withdrawing group, which comprises reacting (a) a compound of the formula (1) Ar—H??(1) wherein Ar has the same meaning as defined above with (b) a compound of the formula (2) wherein Y has the same meaning as defined above, and Z represents a lower alkoxy, or a compound of the formula (3) wherein Y and Z have the same meanings as defined above, in the presence of (c) an acid or a compound which generates a mineral acid by its hydrolysis.

Abstract: The present invention provides a process for producing an aromatic unsaturated compound of the formula (4) wherein Ar represents an optionally substituted aromatic group or an optionally substituted heteroaromatic group, and Y represents an electron withdrawing group, which comprises reacting (a) a compound of the formula (1) Ar—H??(1) wherein Ar has the same meaning as defined above with (b) a compound of the formula (2) wherein Y has the same meaning as defined above, and Z represents a lower alkoxy, or a compound of the formula (3) wherein Y and Z have the same meanings as defined above, in the presence of (c) an acid or a compound which generates a mineral acid by its hydrolysis.

Abstract: The present invention provides a process for producing an aromatic unsaturated compound of the formula (4) wherein Ar represents an optionally substituted aromatic group or an optionally substituted heteroaromatic group, and Y represents an electron withdrawing group, which comprises reacting (a) a compound of the formula (1) Ar—H??(1) wherein Ar has the same meaning as defined above with (b) a compound of the formula (2) wherein Y has the same meaning as defined above, and Z represents a lower alkoxy, or a compound of the formula (3) wherein Y and Z have the same meanings as defined above, in the presence of (c) an acid or a compound which generates a mineral acid by its hydrolysis.

Abstract: An epoxytriazole derivative (V) useful as an intermediate for anti-fungal agents and an intermediate therefor having high quality can be produced economically and efficiently by the following industrial means. A compound of the following formula (I) is reacted with trimethyloxosulfonium salt and the like in the presence of a base to give compound (II), this compound is converted to compound (IV), and this compound is reacted with 1,2,4-triazole in the presence of a base. wherein Ar is a phenyl group optionally substituted by 1 to 3 halogen atom(s) or trifluoromethyl group, R is a hydrogen atom or lower alkyl group, and X is a leaving group.

Abstract: An epoxytriazole derivative (V) useful as an intermediate for anti-fungal agents and an intermediate therefor having high quality can be produced economically and efficiently by the following industrial means. A compound of the following formula (I) is reacted with trimethyloxosulfonium salt and the like in the presence of a base to give compound (II), this compound is converted to compound (IV), and this compound is reacted with 1,2,4-triazole in the presence of a base. wherein Ar is a phenyl group optionally substituted by 1 to 3 halogen atom(s) or trifluoromethyl group, R is a hydrogen atom or lower alkyl group, and X is a leaving group.

Abstract: An epoxytriazole derivative (V) useful as an intermediate for anti-fungal agents and an intermediate therefor having high quality can be produced economically and efficiently by the following industrial means. A compound of the following formula (I) is reacted with trimethyloxosulfonium salt and the like in the presence of a base to give compound (II), this compound is converted to compound (IV), and this compound is reacted with 1,2,4-triazole in the presence of a base.

Abstract: An epoxytriazole derivative (V) useful as an intermediate for anti-fungal agents and an intermediate therefor having high quality can be produced economically and efficiently by the following industrial means. A compound of the following formula (I) is reacted with trimethyloxosulfonium salt and the like in the presence of a base to give compound (II), this compound is converted to compound (IV), and this compound is reacted with 1,2,4-triazole in the presence of a base.

Abstract: A process for preparing a piperazine derivative represented by the formula (V): comprising reacting 1-methyl-3-phenylpiperazine with 2-chloro-3-cyanopyridine in an aprotic polar organic solvent in the presence of a base and an alkali metal halide. The piperazine derivative and its oxalate are compounds useful as preparation intermediates of mirtazapine.