Patents by Inventor Weiqing HE
Weiqing HE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240118263Abstract: Disclosed are target for screening anti-tumor drug, application use thereof and screening method therefor. Disclosed are a target for screening a drug for treating and/or preventing tumors, the target for screening the drug for treating and/or preventing tumors comprise selenoprotein; and a target for screening a drug for preventing tumor metastasis, the target for screening the drug for preventing the tumor metastasis comprising selenoprotein. Also disclosed is a method for screening a drug for treating and/or preventing tumors or a drug for preventing tumor metastasis, the method comprising: interacting a candidate drug with the selenoprotein; and screening the drug for treating and/or preventing tumors or the drug for preventing tumor metastasis according to an affinity between the candidate drug and the selenoprotein; and the candidate drug with a high affinity with the selenoprotein is taken as a candidate primarily screened drug.Type: ApplicationFiled: October 10, 2020Publication date: April 11, 2024Applicant: SHENYANG FUYANG PHARMACEUTICAL TECHNOLOGY CO., LTD.Inventors: Enhong JIANG, Weiqing HE, Mingyu XIA, Dong WANG, Xundong JIANG, Xiaofeng ZHAO
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Publication number: 20230159971Abstract: The present disclosure provides a spiramycin-producing strain, a carrimycin-producing strain, construction method therefor, use thereof and method for increasing the product yield thereof. The provided spiramycin-producing strain has an inactivated gene Lrp (?lrp-SP); and the strain has a preservation number of CGMCC No.16056. The provided carrimycin-producing strain has an inactivated gene Lrp (?lrp-BT); and the strain has a preservation number of CGMCC No.16055. By inactivating the gene Lrp, the yields of spiramycin and carrimycin are increased; and particularly the yield and proportion of a major component of the carrimycin, that is, 4?-O-isovalerylspiramycin III are significantly increased.Type: ApplicationFiled: December 12, 2019Publication date: May 25, 2023Applicant: SHENYANG FUYANG PHARMACEUTICAL TECHNOLOGY CO., LTD.Inventors: Enhong JIANG, Weiqing HE, Xiaofeng ZHAO, Xunlei JIANG
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Publication number: 20220211735Abstract: A medicament for preventing, alleviating and/or treating fibrosis comprises one of Carrimycin, Isovalerylspiramycin I, Isovalerylspiramycin II and Isovalerylspiramycin III; or a combination of two or three of Isovalerylspiramycin I, Isovalerylspiramycin II and Isovalerylspiramycin III. A combination product for preventing, alleviating and/or treating fibrosis comprises a first drug, an effective component of the first drug comprises one of Carrimycin, Isovalerylspiramycin I, Isovalerylspiramycin II and Isovalerylspiramycin III; or a combination of two or three of Isovalerylspiramycin I, Isovalerylspiramycin II and Isovalerylspiramycin III. It also relates to use of the medicine and combination product in preventing, alleviating and/or treating fibrosis.Type: ApplicationFiled: April 16, 2020Publication date: July 7, 2022Applicant: SHENYANG FUYANG PHARMACEUTICAL TECHNOLOGY CO., LTD.Inventors: Hongwei HE, Enhong JIANG, Weiqing HE, Xundong JIANG
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Patent number: 11000708Abstract: Use of carrimycin in Mycobacterium tuberculosis infection resistance comprises the main steps: measuring the activity of carrimycin in Mycobacterium tuberculosis resistance by adopting an absolute concentration method through taking clinical first-line antituberculotics, i.e., isoniazid and rifampicin as controls. The result indicates that carrimycin has obvious superior activity to clinically-separated Mycobacterium tuberculosis including drug-resistant bacteria compared with those of the clinical first-line control drugs, i.e., the isoniazid and the rifampicin, and use of carrimycin in manufacturing drugs for treating tubercle Bacillus infected diseases are expected to be developed.Type: GrantFiled: December 5, 2016Date of Patent: May 11, 2021Assignee: SHENYANG FUYANG PHARMACEUTICAL TECHNOLOGY CO., LTD.Inventors: Yiguang Wang, Yang Jiang, Xiaofeng Zhao, Weiqing He
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Patent number: 10858659Abstract: The present disclosure provides a biosynthetic gene cluster of carrimycin. The biosynthetic gene cluster comprises 44 gene open reading frames (orf), i.e., 5 orfs (orf10-14) encoding polyketide synthase, 9 orfs (orf1, 4-6, 15 and 36-39) related to polyketone synthesis extension unit and modification, 16 orfs (orf9, 16-22, 24, 26, 28, 29, 33-35 and 41) related to glycosyl synthesis, 6 orfs (orf7, 8, 30-32 and 40) related to glycosyl transfer, 2 orfs (orf3 and 25) related to resistance, 4 orfs (orf2, 23, 27 and 42) possibly related to regulation, a tsr resistance marker gene orf (orf43) and a 4?-mycaroseglucoside isovaleryl transferase gene orf (orf44).Type: GrantFiled: November 24, 2016Date of Patent: December 8, 2020Assignee: SHENYANG FUYANG PHARMACEUTICAL TECHNOLOGY CO., LTD.Inventors: Yiguang Wang, Yang Jiang, Xiaofeng Zhao, Weiqing He, Jianlu Dai
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Patent number: 10769423Abstract: A method, a system and a terminal for identity authentication, and a computer readable storage medium are provided. The method includes: acquiring a human body image of a person to be authenticated, and determining from the human body image a plurality of skeleton key points of the person to be authenticated; converting the skeleton key points into feature data, and combining the feature data to form physique feature information characterizing the person to be authenticated; processing the physique feature information using a physique feature model by inputting the physique feature information into the physique feature model, to obtain a processing result; and recognizing the identity of the person to be authenticated based on the processing result of the physique feature model.Type: GrantFiled: October 5, 2018Date of Patent: September 8, 2020Assignee: Baidu Online Network Technology (Beijing) Co., Ltd.Inventors: Fanping Liu, Weiqing He, Wenbin Xie, Xiangli Chen
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Patent number: 10740636Abstract: A method, a system and a terminal for identity authentication, and a computer readable storage medium are provided. The method for identity authentication includes: acquiring a facial image of a person to be authenticated, and determining from the facial image facial feature information of the person to be authenticated; determining a suspected object using a face authentication platform according to the facial feature information of the person to be authenticated; acquiring a human body image of the person to be authenticated, and determining from the human body image a plurality of skeleton key points of the person to be authenticated; converting the skeleton key points into feature data; and recognizing an identity of the person to be authenticated according to the feature data of the person to be authenticated and information of the suspected object.Type: GrantFiled: October 5, 2018Date of Patent: August 11, 2020Assignee: Baidu Online Nework Technology (Beijing) Co., Ltd.Inventors: Wenbin Xie, Weiqing He, Fanping Liu, Xiangli Chen
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Publication number: 20200163984Abstract: Disclosed are a medicament comprising isovaleryl spiramycin I, II and/or III, and use of isovaleryl spiramycin I, II and/or III in manufacturing medicament for treating and/or preventing tumor and the medicament.Type: ApplicationFiled: July 4, 2018Publication date: May 28, 2020Applicant: SHENYANG FUYANG PHARMACEUTICAL TECHNOLOGY CO., LTD.Inventors: Enhong JIANG, Weiqing HE, Jianlu DAI, Yang JIANG, Xunlei JIANG, Xiaofeng ZHAO
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Publication number: 20190278985Abstract: A method, a system and a terminal for identity authentication, and a computer readable storage medium are provided. The method includes: acquiring a human body image of a person to be authenticated, and determining from the human body image a plurality of skeleton key points of the person to be authenticated; converting the skeleton key points into feature data, and combining the feature data to form physique feature information characterizing the person to be authenticated; processing the physique feature information using a physique feature model by inputting the physique feature information into the physique feature model, to obtain a processing result; and recognizing the identity of the person to be authenticated based on the processing result of the physique feature model.Type: ApplicationFiled: October 5, 2018Publication date: September 12, 2019Applicant: Baidu Online Network Technology (Beijing) Co., Ltd .Inventors: Fanping Liu, Weiqing He, Wenbin Xie, Xiangli Chen
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Publication number: 20190279010Abstract: A method, a system and a terminal for identity authentication, and a computer readable storage medium are provided. The method for identity authentication includes: acquiring a facial image of a person to be authenticated, and determining from the facial image facial feature information of the person to be authenticated; determining a suspected object using a face authentication platform according to the facial feature information of the person to be authenticated; acquiring a human body image of the person to be authenticated, and determining from the human body image a plurality of skeleton key points of the person to be authenticated; converting the skeleton key points into feature data; and recognizing an identity of the person to be authenticated according to the feature data of the person to be authenticated and information of the suspected object.Type: ApplicationFiled: October 5, 2018Publication date: September 12, 2019Applicant: Baidu Online Network Technology (Beijing) Co., Ltd .Inventors: Wenbin Xie, Weiqing He, Fanping Liu, Xiangli Chen
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Publication number: 20190093112Abstract: The present disclosure provides a biosynthetic gene cluster of carrimycin. The biosynthetic gene cluster comprises 44 gene open reading frames (orf), i.e., 5 orfs (orf10-14) encoding polyketide synthase, 9 orfs (orf1, 4-6, 15 and 36-39) related to polyketone synthesis extension unit and modification, 16 orfs (orf9, 16-22, 24, 26, 28, 29, 33-35 and 41) related to glycosyl synthesis, 6 orfs (orf7, 8, 30-32 and 40) related to glycosyl transfer, 2 orfs (orf3 and 25) related to resistance, 4 orfs (orf2, 23, 27 and 42) possibly related to regulation, a tsr resistance marker gene orf (orf43) and a 4?-mycaroseglucoside isovaleryl transferase gene orf (orf44).Type: ApplicationFiled: November 24, 2016Publication date: March 28, 2019Applicant: SHENYANG FUYANG PHARMACEUTICAL TECHNOLOGY CO., LTD.Inventors: Yiguang WANG, Yang JIANG, Xiaofeng ZHAO, Weiqing HE, Jianlu DAI
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Publication number: 20190001160Abstract: Use of carrimycin in mycobacterium tuberculosis infection resistance comprises the main steps: measuring the activity of carrimycin in mycobacterium tuberculosis resistance by adopting an absolute concentration method through taking clinical first-line antituberculotics, i.e., isoniazid and rifampicin as controls. The result indicates that carrimycin has obvious superior activity to clinically-separated mycobacterium tuberculosis including drug-resistant bacteria compared with those of the clinical first-line control drugs, i.e., the isoniazid and the rifampicin, and use of carrimycin in manufacturing drugs for treating tubercle bacillus infected diseases are expected to be developed.Type: ApplicationFiled: December 5, 2016Publication date: January 3, 2019Applicant: SHENYANG FUYANG PHARMACEUTICAL TECHNOLOGY CO., LTD .Inventors: Yiguang WANG, Yang JIANG, Xiaofeng ZHAO, Weiqing HE