Patents by Inventor Weiqing SUN

Weiqing SUN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240080679
    Abstract: An elastic cooperative inference architecture and method for UAV cluster can dynamically update the scheduling policy according to the status of each node, and can deal with the failure of some nodes. In addition, the elastic cooperative inference architecture and method can process larger scale complex models on the embedded devices with limited performance carried by UAVs by means of cooperative inference, so as to improve the accuracy of intelligent applications. At the same time, the elastic cooperative inference architecture and method can adaptively update the allocation strategy when some nodes are unavailable or recovered, and improve the survivability of UAV cluster through elastic coordination.
    Type: Application
    Filed: November 2, 2022
    Publication date: March 7, 2024
    Applicant: NANJING UNIVERSITY OF AERONAUTICS AND ASTRONAUTICS
    Inventors: Chao DONG, Yuben QU, Hao SUN, Feiyu WU, Weiqing REN, Qihui WU, Lei ZHANG
  • Publication number: 20220296781
    Abstract: The present application provides an injectable temperature-sensitive composite hydrogel containing adipose-derived mesenchymal stem cells, and a preparation method and application thereof. The present application includes: preparing hydroxypropyl chitin from chitin through modification, preparing a composite with collagen and sodium hyaluronic, constructing the injectable temperature-sensitive composite hydrogel, loading adipose-derived mesenchymal stem cells of New Zealand rabbit and Genipin, and finally forming in-situ the injectable temperature-sensitive composite hydrogel containing adipose-derived mesenchymal stem cells at the physiological temperature.
    Type: Application
    Filed: May 31, 2021
    Publication date: September 22, 2022
    Inventors: Qiang Zhang, Mengjun Hu, Feifei Wu, Wei Huang, Weiqing Sun
  • Patent number: 11214656
    Abstract: A preparation method of a cross-linked sodium hyaluronate gel is disclosed, which including: preparing an alkaline aqueous solution of hyaluronic acid: formulating a sodium hyaluronate alkali liquor with the concentration of 10-30% g/ml; and carrying out a cross-linking reaction: the cross-linking agent used in the cross-linking reaction being divinyl sulfone or 1,4-butanediol diglycidyl ether, the cross-linking reaction being carried out in an alkaline aqueous solution of hyaluronic acid, the reaction temperature of the cross-linking reaction being 20-40° C., the time of the cross-linking reaction being 4-8 h, and the like. The method of this invention has many advantages, such as easily available raw materials, mild reaction conditions, high cross-linking efficiency, simple process and post-treatment, and easy operation.
    Type: Grant
    Filed: December 29, 2019
    Date of Patent: January 4, 2022
    Assignees: Hangzhou Singclean Medical Products Co., Ltd, Zhejiang University of Science and Technology
    Inventors: Zhiguo Zhang, Yange Suo, Wei Huang, Weiqing Sun
  • Patent number: 11098168
    Abstract: Related to is the field of polymer materials, and particularly related to are a method for preparing cross-linked hyaluronic acid gel and a cross-linked hyaluronic acid gel prepared by the method. Under an alkaline condition, a disulfide cross-linking agent is dropwise added into an alkaline solution of hyaluronic acid for cross-linking reaction, and after the reaction is completed, dialysis and freeze drying are carried out to obtain the cross-linked hyaluronic acid gel. A new disulfide cross-linking agent N,N-bis(acroloyl)cystamine is introduced, and it effectively solves degradation regulating problems of cross-linked hyaluronic acid; the disulfide bond ratio is controllable, which can effectively improve a cross-linking modification degree ratio in the cross-linked hyaluronic acid, thereby solving the problem of difficult degradation of highly cross-linked hyaluronic acid gel in the past. The cross-linked material has potential applications in aspects of drug carriers and tissue engineering scaffolds.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: August 24, 2021
    Assignee: Hangzhou Singclean Medical Products Co., Ltd.
    Inventors: Jin Zeng, Weiwei Wang, Weiqing Sun
  • Publication number: 20210154363
    Abstract: The present disclosure provides a preparation method of a collagen melanocyte complex and use of the collagen melanocyte complex. The collagen material is a scaffold material with good biocompatibility, mechanical properties, and degradation performance, which is prepared based on tissue engineering technology. The present disclosure relates to the preparation of a collagen scaffold and the construction of a collagen melanocyte complex. Melanocytes on the scaffold material have higher cell activity and better melanin secretion ability. The collagen melanocyte complex avoids the loss of cell suspension during cell transplantation and provides a good three-dimensional growth environment for cells. The collagen melanocyte complex prepared by the present disclosure can be used in patients with vitiligo or patients with pigment deficiency and epidermal damage.
    Type: Application
    Filed: March 30, 2020
    Publication date: May 27, 2021
    Inventors: Jin Zeng, Caili Ma, Weiqing Sun, Wei Huang
  • Publication number: 20200407516
    Abstract: A preparation method of a cross-linked sodium hyaluronate gel is disclosed, which including: preparing an alkaline aqueous solution of hyaluronic acid: formulating a sodium hyaluronate alkali liquor with the concentration of 10-30% g/ml; and carrying out a cross-linking reaction: the cross-linking agent used in the cross-linking reaction being divinyl sulfone or 1,4-butanediol diglycidyl ether, the cross-linking reaction being carried out in an alkaline aqueous solution of hyaluronic acid, the reaction temperature of the cross-linking reaction being 20-40° C., the time of the cross-linking reaction being 4-8 h, and the like. The method of this invention has many advantages, such as easily available raw materials, mild reaction conditions, high cross-linking efficiency, simple process and post-treatment, and easy operation.
    Type: Application
    Filed: December 29, 2019
    Publication date: December 31, 2020
    Inventors: Zhiguo Zhang, Yange Suo, Wei Huang, Weiqing Sun
  • Patent number: 10865256
    Abstract: Disclosed is a method for preparing cross-linked hyaluronic acid-based cell scaffold material. The hyaluronic acid-based cell scaffold is obtained by subjecting a hyaluronic acid and a disulfide cross-linking agent to an amidation reaction, followed by dialysis-freeze drying. The cell scaffold has abundant pores, good mechanical strength which ensures that the scaffold does not rupture in transplantation, and good biocompatibility. The method is advantageous in that the raw material is easy to obtain, the reaction condition is moderate, and the process is simple. Cross-linked networks of the prepared hydrogel contain disulfide bonds, which can quickly split into single chains at the presence of small molecular glutathione. The hyaluronic acid-based cell scaffold has flexibly controllable mechanical property, disaggregation ability, and swelling property, and therefore has wide applications in facilitating cartilage injury repair, skin repair, cell culture, etc.
    Type: Grant
    Filed: March 1, 2019
    Date of Patent: December 15, 2020
    Assignee: Hangzhou Singclean Medical Products Co., Ltd.
    Inventors: Jin Zeng, Weiqing Sun
  • Publication number: 20200095383
    Abstract: Related to is the field of polymer materials, and particularly related to are a method for preparing cross-linked hyaluronic acid gel and a cross-linked hyaluronic acid gel prepared by the method. Under an alkaline condition, a disulfide cross-linking agent is dropwise added into an alkaline solution of hyaluronic acid for cross-linking reaction, and after the reaction is completed, dialysis and freeze drying are carried out to obtain the cross-linked hyaluronic acid gel. A new disulfide cross-linking agent N,N-bis(acroloyl)cystamine is introduced, and it effectively solves degradation regulating problems of cross-linked hyaluronic acid; the disulfide bond ratio is controllable, which can effectively improve a cross-linking modification degree ratio in the cross-linked hyaluronic acid, thereby solving the problem of difficult degradation of highly cross-linked hyaluronic acid gel in the past. The cross-linked material has potential applications in aspects of drug carriers and tissue engineering scaffolds.
    Type: Application
    Filed: June 27, 2019
    Publication date: March 26, 2020
    Inventors: Jin Zeng, Weiwei Wang, Weiqing Sun
  • Publication number: 20190270829
    Abstract: Disclosed is a method for preparing cross-linked hyaluronic acid-based cell scaffold material. The hyaluronic acid-based cell scaffold is obtained by subjecting a hyaluronic acid and a disulfide cross-linking agent to an amidation reaction, followed by dialysis-freeze drying. The cell scaffold has abundant pores, good mechanical strength which ensures that the scaffold does not rupture in transplantation, and good biocompatibility. The method is advantageous in that the raw material is easy to obtain, the reaction condition is moderate, and the process is simple. Cross-linked networks of the prepared hydrogel contain disulfide bonds, which can quickly split into single chains at the presence of small molecular glutathione. The hyaluronic acid-based cell scaffold has flexibly controllable mechanical property, disaggregation ability, and swelling property, and therefore has wide applications in facilitating cartilage injury repair, skin repair, cell culture, etc.
    Type: Application
    Filed: March 1, 2019
    Publication date: September 5, 2019
    Inventors: Jin Zeng, Weiqing Sun
  • Publication number: 20190055368
    Abstract: A method of preparing a single-phase modified sodium hyaluronate gel, comprising preparing a sodium hyaluronate solution with a mass fraction between 5% to 15% in an alkaline condition at a pH value between 11 to 14, wherein the sodium hyaluronate has a molecular weight between 1.5 million to 4 million Daltons; adding a cross-linking agent to a solution of step (1), wherein the cross-linking agent and the sodium hyaluronate has a molar ratio between 9% to 15%; rapidly mixing for 20 to 40 minutes to form a gel; allowing to stand after subjecting to a water bath at constant temperature; dialyzing with a dialysis membrane to remove un-reacted cross-linking agent and hydroxide ion; homogenizing; and adding a mobile phase and mixing sufficiently to obtain a high viscosity stabilized single-phase modified sodium hyaluronate gel.
    Type: Application
    Filed: June 29, 2018
    Publication date: February 21, 2019
    Inventors: Xijiang Feng, Yan Chen, Weiqing Sun
  • Patent number: 9861722
    Abstract: Disclosed is a method for preparing an oxidized cellulose hemostatic product, including using a sodium hydroxide solution with the concentration of 1 to 5% to pre-process a cellulose product; after removing lignins or impurities on the fiber surface, using an alkaline solution to activate the fiber surface further; after the activating treatment, using demin-water for washing until it is neutral and drying the obtained cellulose product in air to obtain a raw material; using a sodium hydroxide solution with the concentration of 5 to 20% as a solvent; adding the cellulose product, carbamide and ZnO that are 3 to 10%, 2% and 2% of the sodium hydroxide solution respectively.
    Type: Grant
    Filed: July 4, 2016
    Date of Patent: January 9, 2018
    Assignees: Hangzhou Singclean Medical Products Co., Ltd, Zhejiang University of Science and Technology
    Inventors: Zhiguo Zhang, Yange Suo, Wei Huang, Weiqing Sun
  • Patent number: 9720431
    Abstract: A method for optimizing the flexible constraints of an electric power system includes a step S1 of expressing the total power generation cost of the electric power system by using the sum of quadratic functions of active power outputs of all generator sets in the system and constructing an objective function, a step S2 of selecting a multi-dimensional flexible optimization model or a flexible power generation cost optimization model according to the practical situation of the electric power system and the practical purpose of optimization, a step S3 of determining the operating conditions of the electric power system, and a step S4 of carrying out load flow calculation.
    Type: Grant
    Filed: August 27, 2014
    Date of Patent: August 1, 2017
    Assignee: SHANGHAI JIAO TONG UNIVERSITY
    Inventors: Chengmin Wang, Weiqing Sun, Tao Yi, Hongzhong Li, Yong Liu, Jianmin Duan, Dingyao Xiao
  • Publication number: 20170182203
    Abstract: Disclosed is a method for preparing an oxidized cellulose hemostatic product, including using a sodium hydroxide solution with the concentration of 1 to 5% to pre-process a cellulose product; after removing lignins or impurities on the fiber surface, using an alkaline solution to activate the fiber surface further; after the activating treatment, using demin-water for washing until it is neutral and drying the obtained cellulose product in air to obtain a raw material; using a sodium hydroxide solution with the concentration of 5 to 20% as a solvent; adding the cellulose product, carbamide and ZnO that are 3 to 10%, 2% and 2% of the sodium hydroxide solution respectively.
    Type: Application
    Filed: July 4, 2016
    Publication date: June 29, 2017
    Inventors: Zhiguo Zhang, Yange Suo, Wei Huang, Weiqing Sun
  • Publication number: 20170183813
    Abstract: Disclosed are an apparatus and a method for preparing hemostatic gauze with high stability and absorptivity. The apparatus includes a tank body, a tank cover matching the tank body, stainless steel plates within the tank body, an ultrasonic generator under the tank body, a feed pipe and a liquid outlet, where the tank cover is arranged with an air inlet and an air outlet, and the feed pipe, the air inlet, the air outlet and the liquid outlet are all equipped with a valve respectively.
    Type: Application
    Filed: July 4, 2016
    Publication date: June 29, 2017
    Inventors: Zhiguo Zhang, Yange Suo, Wei Huang, Weiqing Sun
  • Publication number: 20150355655
    Abstract: A method for optimizing the flexible constraints of an electric power system includes a step S1 of expressing the total power generation cost of the electric power system by using the sum of quadratic functions of active power outputs of all generator sets in the system and constructing an objective function, a step S2 of selecting a multi-dimensional flexible optimization model or a flexible power generation cost optimization model according to the practical situation of the electric power system and the practical purpose of optimization, a step S3 of determining the operating conditions of the electric power system, and a step S4 of carrying out load flow calculation.
    Type: Application
    Filed: August 27, 2014
    Publication date: December 10, 2015
    Inventors: Chengmin WANG, Weiqing SUN, Tao YI, Hongzhong LI, Yong LIU, Jianmin DUAN, Dingyao XIAO