Patents by Inventor Weiru Wang

Weiru Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 8-aminoisoquinoline compounds and uses thereof
    Patent number: 11612606
    Abstract: 3-Carbonylamino-8-aminoisoquinoline compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the 3-carbonylamino-8-aminoisoquinoline compounds.
    Type: Grant
    Filed: October 3, 2019
    Date of Patent: March 28, 2023
    Assignee: Genentech, Inc.
    Inventors: Jun Liang, Rohan V. Mendonca, Michael Siu, John Tellis, Weiru Wang, BinQing Wei, Bryan Chan, Edna F. Choo, Joy Drobnick, Lewis J. Gazzard, Timothy Heffron
  • Isoquinolines as inhibitors of HPK1
    Patent number: 11566003
    Abstract: Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: January 31, 2023
    Assignee: Genentech, Inc.
    Inventors: Bryan Chan, Joy Drobnick, Lewis Gazzard, Timothy Heffron, Jun Liang, Sushant Malhotra, Rohan Mendonca, Naomi Rajapaksa, Craig Stivala, John Tellis, Weiru Wang, BinQing Wei, Aihe Zhou, Matthew W. Cartwright, Michael Lainchbury, Emanuela Gancia, Eileen Seward, Andrew Madin, David Favor, Kin Chiu Fong, Yonghan Hu, Andrew Good
  • KRAS SPECIFIC ANTIBODIES AND USES THEREOF
    Publication number: 20220112308
    Abstract: Provided herein are anti-KRas antibodies that bind to mutant KRas-GDP and alkylated mutant KRas-GDP and methods of using the same. Also provide herein are method of screening for KRas inhibitors and methods of measuring binding of KRas to the antibodies described herein.
    Type: Application
    Filed: April 28, 2021
    Publication date: April 14, 2022
    Applicant: Genentech, Inc.
    Inventors: MELINDA M. MULVIHILL, JOHN GERARD QUINN, MICAH STEFFEK, WEIRU WANG, JOHN BRUNING, CHRISTOPHER WILLIAMSON DAVIES, MARIE EVANGELISTA, JAMES THOMAS KOERBER
  • CINNOLINE COMPOUNDS AND USES THEREOF
    Publication number: 20220073520
    Abstract: Cinnoline compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the cinnoline compounds.
    Type: Application
    Filed: March 26, 2021
    Publication date: March 10, 2022
    Applicant: Genentech, Inc.
    Inventors: Sushant Malhotra, Michael Siu, Weiru Wang, BinQing Wei, Aihe Zhou, Bryan K. Chan, Lewis J. Gazzard, Timothy Heffron, Michael Lainchbury, Andrew Madin, Eileen Mary Seward, Matthew W. Cartwright, Emanuela Gancia, David Favor, Kin Chiu Fong, Andrew Good, Yonghan Hu
  • ISOQUINOLINE COMPOUNDS FOR THE TREATMENT OF CANCER
    Publication number: 20210332064
    Abstract: 3-Carbonylaminoisoquinoline compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the 3-carbonylaminoisoquinoline compounds.
    Type: Application
    Filed: April 1, 2021
    Publication date: October 28, 2021
    Applicant: Genentech, Inc.
    Inventors: Jun Liang, Rohan V. Mendonca, Michael Siu, John Tellis, Weiru Wang, BinQing Wei, Bryan Chan, Edna F. Choo, Joy Drobnick, Lewis J. Gazzard, Timothy Heffron
  • Naphthyridines as inhibitors of HPK1
    Patent number: 11034692
    Abstract: Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: June 15, 2021
    Assignee: Genentech, Inc.
    Inventors: Bryan Chan, Blake Daniels, Joy Drobnick, Lewis Gazzard, Timothy Heffron, Malcolm Huestis, Jun Liang, Sushant Malhotra, Rohan Mendonca, Naomi Rajapaksa, Michael Siu, Craig Stivala, John Tellis, Weiru Wang, BinQing Wei, Aihe Zhou, Matthew W. Cartwright, Emanuela Gancia, Graham Jones, Michael Lainchbury, Andrew Madin, Eileen Seward, David Favor, Kin Chiu Fong, Andrew Good, Yonghan Hu, Baihua Hu, Aijun Lu
  • ISOQUINOLINES AS INHIBITORS OF HPK1
    Publication number: 20210163417
    Abstract: Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.
    Type: Application
    Filed: July 6, 2020
    Publication date: June 3, 2021
    Applicant: Genentech, Inc.
    Inventors: Bryan Chan, Joy Drobnick, Lewis Gazzard, Timothy Heffron, Jun Liang, Sushant Malhotra, Rohan Mendonca, Naomi Rajapaksa, Craig Stivala, John Tellis, Weiru Wang, BinQing Wei, Aihe Zhou, Matthew W. Cartwright, Michael Lainchbury, Emanuela Gancia, Eileen Seward, Andrew Madin, David Favor, Kin Chiu Fong, Yonghan Hu, Andrew Good
  • 8-AMINOISOQUINOLINE COMPOUNDS AND USES THEREOF
    Publication number: 20200108075
    Abstract: 3-Carbonylamino-8-aminoisoquinoline compounds of formula (I): variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the 3-carbonylamino-8-aminoisoquinoline compounds.
    Type: Application
    Filed: October 3, 2019
    Publication date: April 9, 2020
    Applicant: Genentech, Inc.
    Inventors: Jun LIANG, Rohan V. MENDONCA, Michael SIU, John TELLIS, Weiru WANG, BinQing WEI, Bryan CHAN, Edna F. CHOO, Joy DROBNICK, Lewis J. GAZZARD, Timothy HEFFRON
  • Naphthyridines as inhibitors of HPK1
    Patent number: 10407424
    Abstract: Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: September 10, 2019
    Assignee: Genentech, Inc.
    Inventors: Bryan Chan, Naomi Rajapaksa, Michael Siu, Craig Stivala, John Tellis, Weiru Wang, BinQing Wei, Aihe Zhou, Matthew W. Cartwright, Emanuela Gancia, Graham Jones, Blake Daniels, Michael Lainchbury, Andrew Madin, Eileen Seward, David Favor, Kin Chiu Fong, Andrew Good, Yonghan Hu, Baihua Hu, Aijun Lu, Joy Drobnick, Lewis Gazzard, Timothy Heffron, Malcolm Huestis, Jun Liang, Sushant Malhotra, Rohan Mendonca
  • NAPHTHYRIDINES AS INHIBITORS OF HPK1
    Publication number: 20180282328
    Abstract: Naphthyridine compounds and their use as inhibitors of HPK1 are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the naphthyridine compounds.
    Type: Application
    Filed: March 30, 2018
    Publication date: October 4, 2018
    Applicant: Genentech, Inc.
    Inventors: Bryan Chan, Blake Daniels, Joy Drobnick, Lewis Gazzard, Timothy Heffron, Malcolm Huestis, Jun Liang, Sushant Malhotra, Rohan Mendonca, Naomi Rajapaksa, Michael Siu, Craig Stivala, John Tellis, Weiru Wang, BinQing Wei, Aihe Zhou, Matthew W. Cartwright, Emanuela Gancia, Graham Jones, Michael Lainchbury, Andrew Madin, Eileen Seward, David Favor, Kin Chiu Fong, Andrew Good, Yonghan Hu, Baihua Hu, Aijun Lu
  • ISOQUINOLINES AS INHIBITORS OF HPK1
    Publication number: 20180282282
    Abstract: Isoquinoline compounds and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibitng HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the isoquinoline compounds.
    Type: Application
    Filed: March 30, 2018
    Publication date: October 4, 2018
    Applicant: Genentech, Inc.
    Inventors: Bryan Chan, Joy Drobnick, Lewis Gazzard, Timothy Heffron, Jun Liang, Sushant Malhotra, Rohan Mendonca, Naomi Rajapaksa, Craig Stivala, John Tellis, Weiru Wang, BinQing Wei, Aihe Zhou, Matthew W. Cartwright, Michael Lainchbury, Emanuela Gancia, Eileen Seward, Andrew Madin, David Favor, Kin Chiu Fong, Yonghan Hu, Andrew Good
  • Nucleic acid molecules encoding for BACE1 antibodies
    Patent number: 9879094
    Abstract: The invention provides antibodies to specific neural proteins and methods of using the same.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: January 30, 2018
    Assignee: Genentech, Inc.
    Inventors: Jasvinder Atwal, Yongmei Chen, Cecilia Pui Chi Chiu, Robert A. Lazarus, Weiru Wang, Ryan J. Watts, Yan Wu, Yingnan Zhang
  • Optically variable security threads and stripes
    Patent number: 9844969
    Abstract: In the field of protection of value documents and value commercial goods, the present disclosure relates to the field of security threads or stripes to be incorporated into or onto security documents, and security documents having security threads or stripes. The security threads or stripes include i) first optically variable layer imparting a first different color impression at different viewing angles, ii) second optically variable layer imparting a second different color impression at different viewing angles, iii) first color constant layer having a color matching color impression of the first or second optically variable layer at a first viewing angle, iv) second color constant layer having a color matching color impression of the first or second optically variable layer at a second viewing angle, and v) a substrate. The layers are jointly visible from one side of the security thread or stripe.
    Type: Grant
    Filed: August 1, 2012
    Date of Patent: December 19, 2017
    Assignees: SICPA HOLDINGS SA, ZHONGCHAO SPECIAL SECURITY TECHNOLOGY CO., LTD., CHINA BANKNOTE SICPA SECURITY INK CO., LTD., CHINA BANKNOTE PRINTING AND MINTING CORPORATION
    Inventors: Gebhard Ritter, Raynald Demange, Pierre Degott, Zhongdong Ye, Yuanqi Wu, Fangyi Sun, Weiru Wang, Xiang Li
  • Optically variable security threads and stripes
    Patent number: 9701152
    Abstract: Security threads or stripes include a substrate and i) a first optically variable layer imparting a first different color impression at different viewing angles, ii) a second optically variable layer imparting a second different color impression at different viewing angles, iii) a first color constant layer having a color matching the color impression of the first or second optically variable layer at a first viewing angle, iv) a second color constant layer having a color matching the color impression of the first or second optically variable layer at a second viewing angle, and v) one or more material-free regions, wherein the first optically variable layer, the second optically variable layer, the first color constant layer, the second color constant layer and the one or more material-free regions are jointly visible from one side of the security thread or stripe.
    Type: Grant
    Filed: August 29, 2012
    Date of Patent: July 11, 2017
    Assignees: SICPA HOLDING SA, CHINA BANKNOTE PRINTING AND MINTING CORPORATION, ZHONGCHAO SPECIAL SECURITY TECHNOLOGY CO., LTD., CHINA BANKNOTE SICPA SECURITY INK CO., LTD.
    Inventors: Gebhard Ritter, Pierre Degott, Zhongdong Ye, Fangyi Sun, Weiru Wang, Chunhua Hu, Xiang Li
  • Peptide inhibitors of BACE1
    Patent number: 9624269
    Abstract: The invention provides peptide inhibitors of BACE1 that bind to the active site in a noncanonical fashion, and methods of use thereof.
    Type: Grant
    Filed: November 20, 2015
    Date of Patent: April 18, 2017
    Assignee: Genentech, Inc.
    Inventors: Robert A. Lazarus, Yingnan Zhang, Weiru Wang
  • METHODS AND COMPOSITIONS FOR NEURAL DISEASE IMMUNOTHERAPY
    Publication number: 20170058049
    Abstract: The invention provides antibodies to specific neural proteins and methods of using the same.
    Type: Application
    Filed: August 11, 2016
    Publication date: March 2, 2017
    Applicant: Genentech, Inc.
    Inventors: Jasvinder Atwal, Yongmei Chen, Cecilia Pui Chi Chiu, Robert A. Lazarus, Weiru Wang, Ryan J. Watts, Yan Wu, Yingnan Zhang
  • PEPTIDE INHIBITORS OF BACE1
    Publication number: 20160304563
    Abstract: The invention provides peptide inhibitors of BACE1 that bind to the active site in a noncanonical fashion, and methods of use thereof.
    Type: Application
    Filed: November 20, 2015
    Publication date: October 20, 2016
    Inventors: Robert A. Lazarus, Yingnan Zhang, Weiru Wang
  • Methods and compositions for neural disease immunotherapy
    Patent number: 9453079
    Abstract: The invention provides antibodies to specific neural proteins and methods of using the same.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: September 27, 2016
    Assignee: Genentech, Inc.
    Inventors: Jasvinder Atwal, Yongmei Chen, Cecilia Pui Chi Chiu, Robert A. Lazarus, Weiru Wang, Ryan J. Watts, Yan Wu, Yingnan Zhang
  • Substituted pyrrolo[2,3-b]pyrazines as serine/threonine kinase inhibitors
    Patent number: 9382257
    Abstract: Compounds having the formula I wherein R1 and R2 are as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: July 5, 2016
    Assignee: Genentech, Inc.
    Inventors: Daniel Burdick, Huifen Chen, Shumei Wang, Weiru Wang
  • Peptide inhibitors of BACE1
    Patent number: 9193766
    Abstract: The invention provides peptide inhibitors of BACE1 that bind to the active site in a noncanonical fashion, and methods of use thereof.
    Type: Grant
    Filed: October 12, 2012
    Date of Patent: November 24, 2015
    Assignee: Genentech, Inc.
    Inventors: Robert A. Lazarus, Yingnan Zhang, Weiru Wang