Patents by Inventor Wei-Ting Sun

Wei-Ting Sun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250197501
    Abstract: Disclosed herein is a recombinant antibody or a fragment thereof exhibiting binding affinity and specificity toward B7-H3. According to some embodiments of the present disclosure, the recombinant antibody or its fragment comprises a heavy chain variable (VH) domain and a light chain variable (VL) domain respectively having the amino acid sequences of SEQ ID NOs: 7 and 8. Also disclosed herein are an immunoconjugate comprising the recombinant antibody or its fragment, and a method of treating cancers by use of the present immunoconjugate.
    Type: Application
    Filed: December 19, 2023
    Publication date: June 19, 2025
    Inventors: Chu-Bin LIAO, Chen-Jei HONG, Shih-Chong TSAI, Chien-Yu LIN, Yu-Ping CHOU, Cheng-Chou YU, Wei-Ting SUN
  • Publication number: 20250066793
    Abstract: Disclosed herein are novel single-stranded anti-sense oligonucleotides (ASOs) capable of reducing the transcription of thioredoxin domain containing protein 5 (TXNDC5) mRNA. Also disclosed is use of the single-stranded ASOs as disclosed herein for manufacturing medicaments suitable for treating a disease associated with upregulation of TXNDC5. Accordingly, a pharmaceutical composition comprising the disclosed ASO molecules is provided; as well as a method of treating a subject suffering from TXNDC5-mediated disease via administering to the subject the disclosed single-stranded ASO molecules.
    Type: Application
    Filed: December 28, 2022
    Publication date: February 27, 2025
    Inventors: Ying-Shuan LAILEE, Chia-Wei LIU, Chi-Tang WANG, Pei-Yi TSAI, Chung-Hsiun WU, King LAM, Wei-Ting SUN, Kai-Chien YANG, Hung-Jyun HUANG
  • Patent number: 12091454
    Abstract: A humanized anti-neurotensin receptor 1 (NTSR1) antibody or an antigen-binding fragment thereof. Also, a method for treating, prophylactic treating and/or preventing diseases and/or disorders caused by or related to NTSR1 activity and/or signaling, and a method or kit for detecting NTSR1 in a sample.
    Type: Grant
    Filed: December 28, 2022
    Date of Patent: September 17, 2024
    Assignees: DEVELOPMENT CENTER FOR BIOTECHNOLOGY, NATIONAL HEALTH RESEARCH INSTITUTES
    Inventors: Cheng-Chou Yu, Shu-Ping Yeh, Chao-Yang Huang, Szu-Liang Lai, Shih-Liang Hsiao, Mei-Ling Hou, Tzung-Jie Yang, Wei-Ting Sun, Liang-Yu Hsia, Andrew Yueh, Chiung-Tong Chen, Ren-Huang Wu, Pei-Shan Wu, Han-Shu Hu, Tzu-Chin Wu, Jia-Ni Tian
  • Publication number: 20240238432
    Abstract: A method for modifying glycoproteins is provided. The present disclosure also provides a method for producing glycoprotein-payload conjugates, the conjugates produced thereby, and the use thereof.
    Type: Application
    Filed: December 29, 2023
    Publication date: July 18, 2024
    Inventors: Shih-Hsien CHUANG, Yu-Wei LAI, Cheng-Chou YU, Shu-Ping YEH, Jin-Yu WANG, Shih-Chong TSAI, Wei-Ting SUN, Chin-Yi Huang
  • Publication number: 20240218062
    Abstract: A humanized anti-neurotensin receptor 1 (NTSR1) antibody or an antigen-binding fragment thereof. Also, a method for treating, prophylactic treating and/or preventing diseases and/or disorders caused by or related to NTSR1 activity and/or signaling, and a method or kit for detecting NTSR1 in a sample.
    Type: Application
    Filed: December 28, 2022
    Publication date: July 4, 2024
    Applicants: DEVELOPMENT CENTER FOR BIOTECHNOLOGY, NATIONAL HEALTH RESEARCH INSTITUTES
    Inventors: CHENG-CHOU YU, SHU-PING YEH, CHAO-YANG HUANG, SZU-LIANG LAI, SHIH-LIANG HSIAO, MEI-LING HOU, TZUNG-JIE YANG, WEI-TING SUN, LIANG-YU HSIA, ANDREW YUEH, CHIUNG-TONG CHEN, REN-HUANG WU, PEI-SHAN WU, HAN-SHU HU, TZU-CHIN WU, JIA-NI TIAN
  • Patent number: 11998613
    Abstract: The present disclosure provides an immunoconjugate includes an antibody comprising an antigen-binding fragment that specifically binds to an epitope in mesothelin, N-glycan binding domain and an N-glycan; a linker linking to the N-glycan; and a payload A and a payload B conjugated to the linker, respectively; wherein the payload A and the payload B are the same or different. A pharmaceutical composition comprises the immunoconjugate and a method for treating cancer are also provided in the disclosure.
    Type: Grant
    Filed: June 4, 2021
    Date of Patent: June 4, 2024
    Assignee: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
    Inventors: Shih-Hsien Chuang, Wei-Ting Sun, Ying-Shuan Lailee, Chun-Liang Lai, Wun-Huei Lin, Win-Yin Wei, Shih-Chong Tsai, Cheng-Chou Yu, Chao-Yang Huang
  • Patent number: 11384150
    Abstract: An immunoconjugate, comprising an anti-EGFR antibody or a binding fragment thereof, and a kinase inhibitor.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: July 12, 2022
    Assignees: Development Center for Biotechnology, Tunghai University
    Inventors: Shih-Hsien Chuang, Wei-Ting Chao, Wei-Ting Sun, Hui-Jan Hsu, Wun-Huei Lin
  • Publication number: 20210386866
    Abstract: The present disclosure provides an immunoconjugate includes an antibody comprising an antigen-binding fragment that specifically binds to an epitope in mesothelin, N-glycan binding domain and an N-glycan; a linker linking to the N-glycan; and a payload A and a payload B conjugated to the linker, respectively; wherein the payload A and the payload B are the same or different. A pharmaceutical composition comprises the immunoconjugate and a method for treating cancer are also provided in the disclosure.
    Type: Application
    Filed: June 4, 2021
    Publication date: December 16, 2021
    Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
    Inventors: SHIH-HSIEN CHUANG, WEI-TING SUN, YING-SHUAN LAILEE, CHUN-LIANG LAI, WUN-HUEI LIN, WIN-YIN WEI, SHIH-CHONG TSAI, CHENG-CHOU YU, CHAO-YANG HUANG
  • Publication number: 20210015942
    Abstract: An immunoconjugate having the Formula Ab-[L1-(A-L2-B)m]n, wherein: (a) Ab is an antibody or a binding fragment thereof; (b) L1 and L2 are each independently a linker, wherein L1 and L2 are the same or different and wherein L1 links to L2; (c) A is a target-protein ligand/binder; (d) B is a ubiquitin ligase ligand/binder, and (e) n and m are independently integers from 1 to 8. The target protein includes kinase, G protein-coupled receptors, transcription factor, phosphatases, and RAS superfamily members.
    Type: Application
    Filed: January 9, 2019
    Publication date: January 21, 2021
    Applicant: Development Center for Biotechnology
    Inventors: Shih-Hsien Chuang, Chu-Bin Liao, Wei-Ting Sun, Chen-Hsien Liang, Wun-Huei Lin, Chun-Liang Lai, Her-Sheng Lin
  • Publication number: 20200190199
    Abstract: An immunoconjugate, comprising an anti-EGFR antibody or a binding fragment thereof, and a kinase inhibitor.
    Type: Application
    Filed: December 13, 2017
    Publication date: June 18, 2020
    Inventors: Shih-Hsien Chuang, Wei-Ting Chao, Wei-Ting Sun, Hui-Jan Hsu, Wun-Huei Lin
  • Patent number: 8526714
    Abstract: A method for reconstructing a stereoscopic image stream from a plurality of compressed frames is provided. Each compressed frame consists of a merged image formed by juxtaposing a sampled image frame of a left image and a sampled image frame of a right image. Each sampled image frame has half a number of original pixels disposed at intersections of a plurality of horizontal lines and a plurality of vertical lines in a staggered quincunx pattern in which original pixels surround missing pixels. Each missing pixel is reconstructed according to at least 5 horizontal pixel pairs and 3 vertical pixel pairs in a compressed frame.
    Type: Grant
    Filed: January 13, 2011
    Date of Patent: September 3, 2013
    Assignee: Himax Media Solutions, Inc.
    Inventor: Wei-Ting Sun
  • Publication number: 20120308115
    Abstract: The present disclosure provides a method for adjusting 3-D images converted from 2-D images by using a human visual model. Steps of the method include inputting a 2-D image, dividing the 2-D image into a plurality of blocks, forming a matrix of blocks, obtaining a depth value of each of the plurality of blocks, adjusting the depth value of each of the plurality of blocks according to a position of each of the plurality of blocks, obtaining adjusted depth information of the 2-D image, wherein the adjusted depth information comprises an adjusted depth value of each of the plurality of blocks of the 2-D image, and using depth image based rendering (DIBR) to generate a set of 3-D images according to the adjusted depth information and the 2-D image.
    Type: Application
    Filed: June 2, 2011
    Publication date: December 6, 2012
    Applicant: HIMAX MEDIA SOLUTIONS, INC.
    Inventor: Wei-Ting Sun
  • Publication number: 20120183201
    Abstract: A method for reconstructing a stereoscopic image stream from a plurality of compressed frames is provided. Each compressed frame consists of a merged image formed by juxtaposing a sampled image frame of a left image and a sampled image frame of a right image. Each sampled image frame has half a number of original pixels disposed at intersections of a plurality of horizontal lines and a plurality of vertical lines in a staggered quincunx pattern in which original pixels surround missing pixels. Each missing pixel is reconstructed according to at least 5 horizontal pixel pairs and 3 vertical pixel pairs in a compressed frame.
    Type: Application
    Filed: January 13, 2011
    Publication date: July 19, 2012
    Inventor: Wei-Ting Sun