Abstract: Disclosed herein is a recombinant antibody or a fragment thereof exhibiting binding affinity and specificity toward B7-H3. According to some embodiments of the present disclosure, the recombinant antibody or its fragment comprises a heavy chain variable (VH) domain and a light chain variable (VL) domain respectively having the amino acid sequences of SEQ ID NOs: 7 and 8. Also disclosed herein are an immunoconjugate comprising the recombinant antibody or its fragment, and a method of treating cancers by use of the present immunoconjugate.

Abstract: Disclosed herein are novel single-stranded anti-sense oligonucleotides (ASOs) capable of reducing the transcription of thioredoxin domain containing protein 5 (TXNDC5) mRNA. Also disclosed is use of the single-stranded ASOs as disclosed herein for manufacturing medicaments suitable for treating a disease associated with upregulation of TXNDC5. Accordingly, a pharmaceutical composition comprising the disclosed ASO molecules is provided; as well as a method of treating a subject suffering from TXNDC5-mediated disease via administering to the subject the disclosed single-stranded ASO molecules.

Abstract: A humanized anti-neurotensin receptor 1 (NTSR1) antibody or an antigen-binding fragment thereof. Also, a method for treating, prophylactic treating and/or preventing diseases and/or disorders caused by or related to NTSR1 activity and/or signaling, and a method or kit for detecting NTSR1 in a sample.

Abstract: A method for modifying glycoproteins is provided. The present disclosure also provides a method for producing glycoprotein-payload conjugates, the conjugates produced thereby, and the use thereof.

Abstract: A humanized anti-neurotensin receptor 1 (NTSR1) antibody or an antigen-binding fragment thereof. Also, a method for treating, prophylactic treating and/or preventing diseases and/or disorders caused by or related to NTSR1 activity and/or signaling, and a method or kit for detecting NTSR1 in a sample.

Abstract: The present disclosure provides an immunoconjugate includes an antibody comprising an antigen-binding fragment that specifically binds to an epitope in mesothelin, N-glycan binding domain and an N-glycan; a linker linking to the N-glycan; and a payload A and a payload B conjugated to the linker, respectively; wherein the payload A and the payload B are the same or different. A pharmaceutical composition comprises the immunoconjugate and a method for treating cancer are also provided in the disclosure.

Abstract: An immunoconjugate, comprising an anti-EGFR antibody or a binding fragment thereof, and a kinase inhibitor.

Abstract: The present disclosure provides an immunoconjugate includes an antibody comprising an antigen-binding fragment that specifically binds to an epitope in mesothelin, N-glycan binding domain and an N-glycan; a linker linking to the N-glycan; and a payload A and a payload B conjugated to the linker, respectively; wherein the payload A and the payload B are the same or different. A pharmaceutical composition comprises the immunoconjugate and a method for treating cancer are also provided in the disclosure.

Abstract: An immunoconjugate having the Formula Ab-[L1-(A-L2-B)m]n, wherein: (a) Ab is an antibody or a binding fragment thereof; (b) L1 and L2 are each independently a linker, wherein L1 and L2 are the same or different and wherein L1 links to L2; (c) A is a target-protein ligand/binder; (d) B is a ubiquitin ligase ligand/binder, and (e) n and m are independently integers from 1 to 8. The target protein includes kinase, G protein-coupled receptors, transcription factor, phosphatases, and RAS superfamily members.

Abstract: An immunoconjugate, comprising an anti-EGFR antibody or a binding fragment thereof, and a kinase inhibitor.

Abstract: A method for reconstructing a stereoscopic image stream from a plurality of compressed frames is provided. Each compressed frame consists of a merged image formed by juxtaposing a sampled image frame of a left image and a sampled image frame of a right image. Each sampled image frame has half a number of original pixels disposed at intersections of a plurality of horizontal lines and a plurality of vertical lines in a staggered quincunx pattern in which original pixels surround missing pixels. Each missing pixel is reconstructed according to at least 5 horizontal pixel pairs and 3 vertical pixel pairs in a compressed frame.

Abstract: The present disclosure provides a method for adjusting 3-D images converted from 2-D images by using a human visual model. Steps of the method include inputting a 2-D image, dividing the 2-D image into a plurality of blocks, forming a matrix of blocks, obtaining a depth value of each of the plurality of blocks, adjusting the depth value of each of the plurality of blocks according to a position of each of the plurality of blocks, obtaining adjusted depth information of the 2-D image, wherein the adjusted depth information comprises an adjusted depth value of each of the plurality of blocks of the 2-D image, and using depth image based rendering (DIBR) to generate a set of 3-D images according to the adjusted depth information and the 2-D image.

Abstract: A method for reconstructing a stereoscopic image stream from a plurality of compressed frames is provided. Each compressed frame consists of a merged image formed by juxtaposing a sampled image frame of a left image and a sampled image frame of a right image. Each sampled image frame has half a number of original pixels disposed at intersections of a plurality of horizontal lines and a plurality of vertical lines in a staggered quincunx pattern in which original pixels surround missing pixels. Each missing pixel is reconstructed according to at least 5 horizontal pixel pairs and 3 vertical pixel pairs in a compressed frame.