Abstract: Provided is an anti-HER3 antibody drug conjugate, specifically comprising an antibody moiety, an intermediate linker moiety, and a cytotoxic drug moiety which are linked together. The provided antibody drug conjugate achieves excellent anti-tumor activity or/and better safety. The provided antibody drug conjugate can be used for the treatment of cancer.

Abstract: Methods and apparatuses of encoding a video stream encoded using video point cloud coding include obtaining a source point cloud; generating an occupancy map including one or more pixels based on the source point cloud, an occupancy value associated with each pixel being a non-binary value; encoding the occupancy map to generate an encoded occupancy map, wherein a block of the encoded occupancy map corresponds to the one or more pixels of the occupancy map; selecting an occupancy value of the block based on the one or more pixels; and generating an encoded video stream based on the selected occupancy value.

Abstract: This disclosure relates generally to image processing and specifically to processing panorama images using neural networks to generate depth maps, layouts, semantic maps or the like with reduced distortion and improved continuity. Methods and systems are described for generating such maps by leveraging several essential properties of these panorama images and by using a panorama panel representation and a neural network framework. A panel geometry embedding network is incorporated for encoding both the local and global geometric features of the panels in order to reduce negative impact of panoramic distortion. A local-to-global transformer network is also incorporated for capturing geometric context and aggregating local information within a panel and panel-wise global context.

Abstract: A method of encoding a current picture includes based on a first determination indicating that the padding is not applied, encoding the plurality of sub-regions without padding; based on the first determination indicating that the padding is applied, making a second determination that the padding comprises wrap-around padding; based on the second determination indicating that the padding does not comprise wrap-around padding, applying repetition padding to the plurality of sub-regions; based on the second determination indicating that the padding comprises the wrap-around padding, obtaining an offset value from the picture partitioning information and encoding the plurality of sub-regions based on the wrap-around padding and the offset value; generating picture partitioning information based on the first determination and the second determination; and encoding the current picture based on the encoded plurality of sub-regions and the picture partitioning information.

Abstract: Methods and apparatuses of encoding a video stream using video point cloud coding include obtaining a source point cloud; obtaining a geometry-reconstructed point cloud, wherein the geometry-reconstructed point cloud is reconstructed using lossy coding; obtaining a target point included in the geometry-reconstructed point cloud; performing at least one of a forward K-dimensional (KD)-tree search to determine a first plurality of points of the source point cloud which are nearest neighbors to the target point, and a backward KD-tree search to determine a second plurality of points of the source point cloud for which the target point is a nearest neighbor; determining an average color value based on at least one of a first average color value of the first plurality of points and a second average color value of the second plurality of points; selecting a color value for the target point based on the average color value; and generating an encoded video stream based on the selected color value.

Abstract: A method for 3D human model reconstruction and animation includes receiving a two-dimensional (2D) image of a human, segmenting the 2D image into a foreground with the human and a background without the human in the 2D image, generating a parametric model comprising a pose, a shape, and one or more rigging parameters based on the human in the foreground, predicting a textured three-dimensional (3D) model using implicit surface reconstruction of the human in the foreground, aligning the parametric model and the textured 3D model using a 3D registration, and generating a textured 3D clothed human model based on the aligned parametric model and the predicted textured 3D model.

Abstract: A phosphate compound of a trifluoromethyl-substituted sulfonamide compound for selectively inhibiting anti-apoptotic protein BCL-2, a preparation method therefor, a pharmaceutical composition containing the compound, and the use thereof in the treatment of anti-apoptotic protein BCL-2-related diseases, such as cancer.

Abstract: A method, computer program, and computer system is provided for 3D pose graph reconstruction. 3D reconstruction of indoor buildings for VR/AR applications, such as virtual touring, digital museum, and virtual home sale, may be performed based on estimating pose graph and transformation matrix between cameras by recognizing markers on the ground in panorama images. Image data corresponding to one or more views of a first camera is received. One or more markers corresponding to a second camera are identified within the received image data. A pose graph corresponding to the one or more views of the first camera is constructed based on the identified one or more markers, the pose graph comprising at least an edge.

Abstract: Reconstructing a coded current picture for video decoding including decoding picture partitioning information corresponding to the current picture; determining whether padding is applied to sub-regions of the current picture using the picture partitioning information; based on determining that padding is not applied, decoding the sub-regions without padding the sub-regions; based on determining that padding is applied, determining whether the padding includes wrap-around padding using the picture partitioning information; based on determining that the padding does not include wrap-around padding, applying repetition padding to the sub-regions, and decoding the sub-regions using the repetition padding; based on determining that the padding includes wrap-around padding, applying the wrap-around padding to the sub-regions, and decoding the sub-regions using the wrap-around padding; and reconstructing the current picture based on the decoded sub-regions.

Abstract: Methods and apparatuses of encoding a video stream using video point cloud coding include obtaining a source point cloud; generating a geometry map and a texture map based on the source point cloud; generating a reconstructed geometry map and a reconstructed texture map using lossy coding without using recoloring, wherein a resolution of the reconstructed geometry map is same as a resolution of the reconstructed texture map; obtaining a point of the source point cloud corresponding to a geometry pixel of the geometry map and a texture pixel of the texture map; selecting a color of the texture pixel based on a color of the obtained point; and generating an encoded video stream based on the selected color, the geometry map, and the texture map.

Abstract: The present disclosure is related to compositions and processes of preparation of a radiotherapeutic hydrogel that includes anionic cytotoxic radioactive agents, cationic biopolymer or the cationic biopolymer-based NP/MP, and biopolymer hydrogel. In some embodiments, the radiotherapeutic hydrogel can be potentially applied as a new approach of SIRT as adjuvant treatment (e.g., via a local administration) to selectively kill the residual cancers.

Abstract: Provided is an antibody drug conjugate, specifically comprising a therapeutic antibody moiety, an intermediate linker moiety and a cytotoxic drug moiety which are linked. The therapeutic antibody moiety is an antibody against an HER2 target. The cytotoxic drug moiety is a camptothecin topoisomerase I inhibitor. The cytotoxic drug moiety or the linker-cytotoxic drug moiety is modified by means of deuterium substitution. The antibody drug conjugate can be used for the prevention or treatment of cancers.

Abstract: A method, computer program, and computer system is provided for coding video data. Video data including a reference view and a current view is received. A co-located block in the reference view is identified for a current block in the current view. A predicted block vector is calculated based on an offset vector between the current block and the co-located block, and a disparity vector between the co-located block and the reference block in the reference view. The video data is encoded/decoded based on the calculated predicted block vector.

Abstract: A catalyst for residue suspended bed hydrocracking and a preparation method and application thereof are disclosed. The catalyst is obtained by mixing a VIM or VIIIB group transition metal salt solution with a ferric salt solution, conducting parallel-flow precipitation with an alkaline solution, adding a silicon source, and then conducting aging, washing, drying, and calcination. The catalyst has a stable structure and excellent hydrogenation activity. When used in a residue suspended bed hydrocracking reaction, the yield of liquid is up to 91 wt %, the yield of gasoline and diesel oil is up to 60 wt %, and both the yield of gas and the yield of coke are low. The catalyst has a good application prospect in residue suspended bed hydroconversion process.

Abstract: A method for 3D human model reconstruction and animation includes receiving a two-dimensional (2D) image of a human, segmenting the 2D image into a foreground with the human and a background without the human in the 2D image, generating a parametric model comprising a pose, a shape, and one or more rigging parameters based on the human in the foreground, predicting a textured three-dimensional (3D) model using implicit surface reconstruction of the human in the foreground, aligning the parametric model and the textured 3D model using a 3D registration, and generating a textured 3D clothed human model based on the aligned parametric model and the predicted textured 3D model.

Abstract: A plurality of two-dimensional (2D) images of the scene is received. Geometric information and semantic information of each of the plurality of 2D images is determined. The geometric information indicates a detected line and a reference direction in the respective 2D image. The semantic information includes classification information of pixels in the respective 2D image. A layout estimation associated with the respective 2D image of the scene is determined based on the geometric information and the semantic information of the respective 2D image. A combined layout estimation associated with the scene is determined based on a plurality of the determined layout estimations associated with the plurality of 2D images of the scene. The Manhattan layout associated with the scene is generated based on the combined layout estimation. The Manhattan layout includes at least a three-dimensional (3D) shape of the scene that includes wall faces orthogonal with respect to each other.

Abstract: A crystal of a trifluoromethyl/chloro disubstituted sulfonamide selective BCL-2 inhibitor, specifically related to a crystal of a compound of formula I, a preparation method therefor, and use thereof in preventing and treating diseases related to anti-apoptotic protein BCL-2, such as cancers.

Abstract: Aspects of the disclosure include methods, apparatuses, and non-transitory computer-readable storage mediums for generating a three-dimensional (3D) geometry of a room from a panorama image of the room. An apparatus includes processing circuitry that determine two-dimensional (2D) positions of wall corner points of the room in the panorama image based on a user input. Each wall corner point is in one of a floor plane or a ceiling plane of the room. The processing circuitry calculates 3D positions of the wall corner points based on the 2D positions of the wall corner points, a size of the panorama image, and a distance between the floor plane and a capture position of a device capturing the panorama image, determines a room layout based on an order of the wall corner points, and generates the 3D geometry based on the room layout and the 3D positions of the wall corner points.

Abstract: Aspects of the disclosure include methods, apparatuses, and non-transitory computer-readable storage mediums for generating a floor plan from a point cloud model. An apparatus includes processing circuitry that receives an input three-dimensional point cloud corresponding to a three-dimensional space. The processing circuitry determines a plurality of wall planes in the received input three-dimensional point cloud. The processing circuitry generates a plurality of line segments. Each line segment is generated by projecting a respective wall plane of the plurality of wall planes to a floor plane in the three-dimensional space. The processing circuitry represents the plurality of wall planes in the three-dimensional space using the plurality of line segments in a two-dimensional space corresponding to the floor plan. The processing circuitry adjusts the plurality of line segments in the two-dimensional space to improve the floor plan.

Abstract: Methods and apparatuses of encoding a video stream encoded using video point cloud coding include obtaining a source point cloud; generating an occupancy map including one or more pixels based on the source point cloud, an occupancy value associated with each pixel being a non-binary value; encoding the occupancy map to generate an encoded occupancy map, wherein a block of the encoded occupancy map corresponds to the one or more pixels of the occupancy map; selecting an occupancy value of the block based on the one or more pixels; and generating an encoded video stream based on the selected occupancy value.