Abstract: A nanoparticle comprising an outer surface comprising a plasma membrane derived from a cell that can be infected with a respiratory virus, including a human lung epithelial cell expressing ACE-2 receptor. Methods of manufacture and use for preventing or treating viral infections, such as coronavirus infection in a subject in need are disclosed.

Abstract: Provided is a self-assembling peptide, a preparation method, the self-assembling peptide formulations and use, and it is related to the field of biotechnology. The self-assembling peptide provided by the present disclosure has a general formula as shown in AC-Pro-X1-X3-X2-X3-X1-X3-X2-Pro-amide. Through experiments, the inventors of the present disclosure found that the self-assembling peptide provided by the present disclosure, because solubility is high and difficulty of synthesis and purification is less compared with a traditional self-assembling peptide, is more feasible for industrial production, and even cheaper to produce. In mass synthesis and purification, the number of purification decreases, the single purification amount increases, the purity of a crude peptide can reach 90% or more, and the cost is greatly reduced.

Abstract: Provided is a method of manufacturing fiber with aligned porous structure, an apparatus, and applications of the fiber. The apparatus comprises: a fiber extrusion unit, a freezing unit, and a collection unit for collecting the frozen fibers, wherein fibers extruded from the fiber extrusion unit pass through the freezing unit. Continuous and large scale preparation of such fiber with aligned porous structure is achieved by combining directional freezing and solution spinning.

Abstract: The present disclosure relates to devices, e.g, extracorporeal blood purification (EBP) devices, which comprise a cartridge or sorbent comprising a cellular membrane derived from a cell. The present disclosure also relates methods for removing or reducing a substance, e.g, an undesirable substance, from a fluid, e.g, a subject’s blood, using the devices or EBP devices.

Abstract: The invention utilizes swelling and fusion effects of graphene oxide in a solvent to implement cross-linked bonding of a graphene material itself and materials such as polymers, metal, paper, glass, carbon materials, and ceramics. The present invention not only overcomes the shortcoming in traditional adhesives of residual formaldehyde, but also has short drying time, high bonding strength and high corrosion resistance. The present invention is widely applied in the fields of aviation, aerospace, automobiles, machinery, construction, chemical, light industry, electronics, electrical appliances, and daily life, etc.

Abstract: The present invention relates to processes and systems for preparing nanoparticles, cellular or viral membranes and/or cellular or viral membrane coated nanoparticles using or comprising, inter alia, a multi-inlet vortexing reactor, tangential flow filtration (TFF) and/or a high shear fluid processor such as a microfluidizer (or a microfluidizer processor). The present invention also relates to the nanoparticles, cellular or viral membranes and/or cellular or viral membrane coated nanoparticles prepared by the present processes and systems, and the uses and/or applications of the nanoparticles, cellular or viral membranes and/or cellular or viral membrane coated nanoparticles.

Abstract: The present invention relates to processes and systems for preparing nanoparticles, cellular or viral membranes and/or cellular or viral membrane coated nanoparticles using or comprising, inter alia, a multi-inlet vortexing reactor, tangential flow filtration (TFF) and/or a high shear fluid processor such as a microfluidizer (or a microfluidizer processor). The present invention also relates to the nanoparticles, cellular or viral membranes and/or cellular or viral membrane coated nanoparticles prepared by the present processes and systems, and the uses and/or applications of the nanoparticles, cellular or viral membranes and/or cellular or viral membrane coated nanoparticles.

Abstract: The present disclosure relates to nanoparticles containing cellular membrane and uses thereof. The nanoparticle comprises an interior compartment (or an inner core) and an outer surface (or shell) comprising a cellular membrane derived from a cell, said interior compartment (or an inner core) not providing a solid support to said cellular membrane in said outer surface (or shell). The present disclosure also relates to processes of making the nanoparticles. The present disclosure further relates to compositions comprising the nanoparticles and methods of using the nanoparticles.

Abstract: Disclosed in the present disclosure are a self-fused graphene fiber and a method of preparing the same. Dried graphene oxide fibers are soaked in a solvent to swell and then the fibers are pulled out and coalesced. After being dried, the graphene oxide fibers are fused together, and then are further reduced to obtain a self-fused graphene fiber. The entire self-fusion process can be quickly finished within one minute without adding any additional binder. The operation is simple and time-saving. The process is environmentally friendly; the bond strength is high, and the excellent properties such as outstanding mechanical strength and electrical conductivity of the graphene fibers themselves can be maintained. The present disclosure has great research and application value for further preparation of two-dimensional graphene fabrics or three-dimensional network bulks with excellent performance.

Abstract: A biomimetic oxygen delivery carrier is provided by employing natural cell membrane as a stabilizer for fluorocarbon nanoemulsions. The resulting formulation exhibits a high capacity for delivering oxygen and can be used to successfully resuscitate subjects in need due to for example hemorrhagic shock. This natural-synthetic platform can alleviate the impact of blood shortages in clinical settings among other uses.

Abstract: The present invention relates to processes and systems for preparing nanoparticles, cellular or viral membranes and/or cellular or viral membrane coated nanoparticles using or comprising, inter alia, a multi-inlet vortexing reactor, tangential flow filtration (TFF) and/or a high shear fluid processor such as a microfluidizer (or a microfluidizer processor). The present invention also relates to the nanoparticles, cellular or viral membranes and/or cellular or viral membrane coated nanoparticles prepared by the present processes and systems, and the uses and/or applications of the nanoparticles, cellular or viral membranes and/or cellular or viral membrane coated nanoparticles.

Abstract: A nanoparticle comprising an outer surface comprising a plasma membrane derived from a cell that can be infected with a respiratory virus, including a human lung epithelial cell expressing ACE-2 receptor. Methods of manufacture and use for preventing or treating viral infections, such as coronavirus infection in a subject in need are disclosed.

Abstract: The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the above compositions for decreasing or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject. The exemplary toxin is a biological toxin such as a viral, bacterial, fungal, plant or animal toxin.

Abstract: The present invention relates to viral or cellular membrane coated nanostructures. Nanostructure networks, nanoscaffolds and articles of manufacture comprising the nanostructure, and uses thereof, are also provided. The present invention also relates to methods for anchoring, attaching and/or growing a target cell. Target cells, constituent(s) of the target cells, target substances made by the target cells or culture medium of the target cells prepared by the present methods, and uses thereof, are also provided.

Abstract: The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the above compositions for decreasing or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject. The exemplary toxin is a biological toxin such as a viral, bacterial, fungal, plant or animal toxin.

Abstract: The present invention relates to viral or cellular membrane coated nanostructures. Nanostructure networks, nanoscaffolds and articles of manufacture comprising the nanostructure, and uses thereof, are also provided. The present invention also relates to methods for anchoring, attaching and/or growing a target cell. Target cells, constituent(s) of the target cells, target substances made by the target cells or culture medium of the target cells prepared by the present methods, and uses thereof, are also provided.

Abstract: Provided is a method of manufacturing fiber with aligned porous structure, an apparatus, and applications of the fiber. The apparatus comprises: a fiber extrusion unit, a freezing unit, and a collection unit for collecting the frozen fibers, wherein fibers extruded from the fiber extrusion unit pass through the freezing unit. Continuous and large scale preparation of such fiber with aligned porous structure is achieved by combining directional freezing and solution spinning.

Abstract: The invention utilizes swelling and fusion effects of graphene oxide in a solvent to implement cross-linked bonding of a graphene material itself and materials such as polymers, metal, paper, glass, carbon materials, and ceramics. The present invention not only overcomes the shortcoming in traditional adhesives of residual formaldehyde, but also has short drying time, high bonding strength and high corrosion resistance. The present invention is widely applied in the fields of aviation, aerospace, automobiles, machinery, construction, chemical, light industry, electronics, electrical appliances, and daily life, etc.

Abstract: The present invention provides for compositions comprising a polymeric hydrogel impregnated with a toxin-absorbing or binding nanoparticle. The present invention also provides for the use of the above compositions for decreasing or neutralizing the effect of a toxin, or for treating or preventing an infection by a microbe that produces a toxin, in a subject. The exemplary toxin is a biological toxin such as a viral, bacterial, fungal, plant or animal toxin.

Abstract: A virtual machine shared by tenants triggers an accept wrapper for an accept operation. The virtual machine, in response to the accept operation bound to a particular address call for binding a particular tenant to a particular IP address and a shared port, creating a first socket to listen to a particular IP address assigned to a particular tenant and creating a second socket to listen to another port. The virtual machine, in response to a connection occurring on the first socket, creating a first thread and forwarding the first thread to the accept wrapper from the particular IP address and in response to the connection occurring on the second socket, creating a second thread and forwarding the second thread to the accept wrapper from the another port. The virtual machine returns at least one of the first thread and the second thread in response to the accept operation call.