Abstract: Disclosed are a new interleukin-2 (IL-2) mutant protein and the use thereof. Compared with wild-type IL-2, the IL-2 mutant protein has improved properties, such as an improved IL-2 receptor binding property and improved druggability. Also provided are a fusion protein, dimer and immunoconjugate comprising the IL-2 mutant protein, nucleic acids encoding the IL-2 mutant protein, the dimer and the immunoconjugate, and a vector and host cell comprising the nucleic acid. Further provided are methods for preparing the IL-2 mutant protein, the fusion protein, the dimer and the immunoconjugate, a pharmaceutical composition containing same, and the therapeutic use thereof.

Abstract: This disclosure relates generally to image processing and specifically to processing panorama images using neural networks to generate depth maps, layouts, semantic maps or the like with reduced distortion and improved continuity. Methods and systems are described for generating such maps by leveraging several essential properties of these panorama images and by using a panorama panel representation and a neural network framework. A panel geometry embedding network is incorporated for encoding both the local and global geometric features of the panels in order to reduce negative impact of panoramic distortion. A local-to-global transformer network is also incorporated for capturing geometric context and aggregating local information within a panel and panel-wise global context.

Abstract: Examples of the present disclosure disclose a memory and an operation method thereof, a memory system and an electronic device. The memory includes a memory cell array and a page buffer, wherein the page buffer is disposed correspondingly to a bit line of the memory cell array and includes: latches which are coupled to the bit line through a sense node of the page buffer; and at least one common data transmission circuit, wherein a first port of the common data transmission circuit is coupled with the sense node and a second port of the common data transmission circuit is coupled with at least two of the latches, wherein the at least two of the latches are configured for data sensing through the common data transmission circuit respectively.

Abstract: The present invention relates to an antibody specifically binding to CD79b and a bispecific antibody specifically binding to CD79b and CD3, nucleic acids encoding the anti-CD79b antibody and the anti-CD79b×CD3 bispecific antibody, vectors comprising the nucleic acids, host cells comprising the nucleic acids or the vectors, and pharmaceutical compositions comprising the antibodies or antigen-binding fragments thereof.

Abstract: According to some aspects, a memory includes a bit line discharge circuit and a bit line coupled to the bit line discharge circuit. The bit line discharge circuit includes a transistor, a control branch, and a first discharge branch. A gate of the transistor is connected with the control branch. One of a source or a drain of the transistor is connected with the first discharge branch. Another of the source or the drain of the transistor is connected with the bit line. The control branch is configured to turn on the transistor. The first discharge branch is configured to discharge the bit line at a set discharge speed when the transistor is turned on.

Abstract: A driving method and driving device for a display panel, and a display device. The driving method includes: in a first driving stage, controlling a data voltage signal input terminal to transmit a voltage corresponding to a data voltage to a gate of a drive transistor; and in a second driving stage, controlling the data voltage signal input terminal to transmit a hold voltage to a source of the drive transistor to couple the voltage of the gate of the drive transistor through the hold voltage of the source of the drive transistor.

Abstract: A method and a system for diagnosing an open circuit (OC) fault of an insulated gate bipolar transistor (IGBT) of a T-type three-level (T23L) inverter under multiple power factors based on instantaneous current distortion are provided. Similar characteristics of current distortion may be caused by an OC fault of a T23L inverter, making it is difficult to locate the fault. The method for diagnosing an OC fault of a grid-connected T23L inverter, can diagnose the OC fault hierarchically; four switch transistors in a phase can be divided into two groups according to the similarity analysis of current distortion under different power factors; group-based fault diagnosis is realized by half cycles in which a zero domain occurs; and then, a specific switching signal is injected to realize equipment-based OC fault diagnosis. The OC fault diagnosis of a T23L inverter is realized without additional hardware circuits.

Abstract: A method of operating a memory device is disclosed. The memory device includes a memory string coupled with a bit line and a common source line. An erase voltage is applied to the bit line and the common source line in an erase operation. The bit line and the common source line are discharged in a discharge operation after the erase operation. A voltage difference between the bit line and the common source line is less than a first predetermined value during a period of the discharge operation.

Abstract: A method, computer program, and computer system is provided for 3D pose graph reconstruction. 3D reconstruction of indoor buildings for VR/AR applications, such as virtual touring, digital museum, and virtual home sale, may be performed based on estimating pose graph and transformation matrix between cameras by recognizing markers on the ground in panorama images. Image data corresponding to one or more views of a first camera is received. One or more markers corresponding to a second camera are identified within the received image data. A pose graph corresponding to the one or more views of the first camera is constructed based on the identified one or more markers, the pose graph comprising at least an edge.

Abstract: A wand includes a hinge configured to pivotally connect first and second wand segments in an extended configuration and a storage configuration. A first locking mechanism locks the wand in extended configuration. A second locking mechanism includes a rod, a sliding lever, a plunger, and a plunger cavity. The plunger is configured to be received in the plunger cavity to lock the wand in the storage configuration. When in the extended configuration, depressing a single actuator pivots the locking arm, causes the hook/pawl to be removed from the locking cavity, and unlocks the wand. When in the storage configuration, depressing the single actuator causes the rod to move in a first direction, causes the sliding rod to move a second direction, and urges the plunger out of the plunger cavity.

Abstract: A fast calibration test system and method for a phased-array antenna, which belongs to the technical field of antenna measurement, relates to a near-field test system, and relates in particular to the fast calibration and a directional diagram test on a phased-array antenna.

Abstract: The present disclosure relates to a method for determining a target spot path, which is applied to a determining system including a shooting device and a locating device that are separate from each other, and a calibration device connected to the shooting device, the method comprising: S1. obtaining a three-dimensional partial image for an affected part and a virtual path located in the three-dimensional partial image; S2. matching a simulated two-dimensional image obtained based on projection of the three-dimensional partial image with a two-dimensional projection image obtained based on the affected part; S3. determining a surgical guide path on the two-dimensional projection image that corresponds to the virtual path according to position information of the virtual path on the simulated two-dimensional image, when the simulated two-dimensional image and the two-dimensional projection image are matched; and/or S4.

Abstract: The present disclosure provides a method for discharging a memory device after an erase operation. The method comprises grounding a source line of the memory device; and switching on a discharge transistor to connect a bit line of the memory device to the source line by maintaining a constant voltage difference between a gate terminal of the discharge transistor and the source line. The method also includes comparing an electrical potential of the source line with a first predetermined value; and floating the gate terminal of the discharge transistor when the electrical potential of the source line is lower than the first predetermined value.

Abstract: The present disclosure relates to a method for efficiently enriching lutein in broccoli sprouts under ?-aminobutyric acid combined with sodium chloride stress. In the present disclosure, Qingfeng broccoli seeds with plump particles, uniform size and germination ability are selected as raw materials; after removing impurities and being disinfected by a NaClO solution, the seeds are sprayed with distilled water for one day, then sprayed with a mixed aqueous solution of NaCl and ?-aminobutyric acid, to obtain broccoli sprouts.

Abstract: In one aspect, compositions and therapeutic use thereof are provided that can inhibit ?-synuclein cell-to-cell transmission. In embodiment, methods are provided to treat a mammal such as a human that is suffering from or susceptible to an ?-synucleinopathy that include administering to the mammal an effective amount of one or more metal nanozymes.

Abstract: The present disclosure provides a method for discharging a memory device after an erase operation. The method comprises grounding a source line of the memory device; and switching on a discharge transistor to connect a bit line of the memory device to the source line by maintaining a constant voltage difference between a gate terminal of the discharge transistor and the source line. The method also includes comparing an electrical potential of the source line with a first predetermined value; and floating the gate terminal of the discharge transistor when the electrical potential of the source line is lower than the first predetermined value.

Abstract: A wand includes a hinge configured to pivotally connect first and second wand segments in an extended configuration and a storage configuration. A first locking mechanism locks the wand in extended configuration. A second locking mechanism includes a rod, a sliding lever, a plunger, and a plunger cavity. The plunger is configured to be received in the plunger cavity to lock the wand in the storage configuration. When in the extended configuration, depressing a single actuator pivots the locking arm, causes the hook/pawl to be removed from the locking cavity, and unlocks the wand. When in the storage configuration, depressing the single actuator causes the rod to move in a first direction, causes the sliding rod to move a second direction, and urges the plunger out of the plunger cavity.

Abstract: The present disclosure discloses a multi-device recording synchronization method and system, and a conference system, and belongs to the field of recording marking. For the problem in the prior art that a device that supports a recording marking function only supports generation and use on a single device, the present disclosure provides a system, including one master and a plurality of slaves. The master is connected to the plurality of slaves. The master operates according to the instruction sent by the slave and broadcasts state information globally. Through a network connection between the master and the slave, the master stores, on the master, recording and marking data sent by the slave, and synchronizes the data between devices, and a multi-device recording marking and synchronization system is applied to a conference system. The present disclosure is very convenient for use and has simple operation logic and low system costs.

Abstract: The present disclosure relates to a method for efficiently enriching lutein in broccoli sprouts under ?-aminobutyric acid combined with sodium chloride stress. In the present disclosure, Qingfeng broccoli seeds with plump particles, uniform size and germination ability are selected as raw materials; after removing impurities and being disinfected by a NaClO solution, the seeds are sprayed with distilled water for one day, then sprayed with a mixed aqueous solution of NaCl and ?-aminobutyric acid, to obtain broccoli sprouts.

Abstract: A printed composite including a substrate layer having an upper substrate surface for printing; an ink layer having an upper ink surface and an opposed lower ink surface, the lower ink surface being disposed on the upper substrate surface; and a protective layer covering the upper ink surface is disclosed. During use, the protective layer prevents the ink layer from being damaged, such as removal or discoloration, as could otherwise happen by exposure to sunscreen location. A method for preparing the printed composite is also provided.