Abstract: Disclosed is an apparatus for enriching and screening a target object such as a cell, bacteria or biomolecule from a sample. The apparatus includes a plurality of multi-channel mesh bodies arranged in parallel, and each multi-channel mesh body includes a mesh body formed by intersecting a plurality of threads, a plurality of screen pores formed by intersecting the plurality of threads, and a capturing layer formed on the mesh body. The capturing layer includes a capturing material specifically binding with the target object.

Abstract: Disclosed is a hierarchical management method and system for a terminal device. The terminal device comprises at least one control system, and at least one peripheral apparatus, which is connected to the control system. In the method, when a terminal device receives a wake-up signal during dormancy, a control system corresponding to the wake-up signal is woken up, and the control system in a wake-up state grades an operation mode of the control system according to a data load; and according to the operation mode, a peripheral apparatus that needs to perform data processing is woken up.

Abstract: A sample mounting device for direct tensile test of rock mass is provided, which includes a first positioning stage, a second positioning stage, a first support piece, a second support piece, and a screw drive mechanism. The second positioning stage is arranged above the first positioning stage and capable of moving up and down, and cushion blocks for gluing with the rock mass are coaxially and detachably arranged at opposite ends of the first positioning stage and the second positioning stage, and a rock mass mounting area is formed between the two cushion blocks. A screw of the screw drive mechanism includes a first thread segment and a second thread segment with opposite thread directions. The first support piece is connected with the first thread segment through a nut seat, and the second support piece is connected with the second thread segment through a nut seat.

Abstract: The present invention relates to chimeric antigen receptor (CAR)-T cells, and particularly, although not exclusively, to anti-T-cell receptor (TCR) V-beta CARs, and to their use in immunotherapy, and for treating, preventing or ameliorating cancer, such as T-cell lymphomas, various microbial infections, such as HIV and TB, and also autoimmune disease. The invention is especially concerned with the use of CAR-engineered mucosal-associated invariant T (MAIT) cells, and to novel methods for stimulating, isolating and expanding highly purified MAIT cells, which can then be engineered into such CAR-MAIT cells. The invention extends to genetic constructs per se, and to their use in generating the CAR-MAIT cells, and to transduced CAR-MAIT cells per se. The invention also extends to various medical uses of the constructs and transduced CAR-MAIT cells, and to pharmaceutical compositions comprising these constructs and CAR-MAIT cells.

Abstract: The present invention relates to chimeric antigen receptor (CAR)-T cells, and particularly, although not exclusively, to their use in immunotherapy, and for treating, preventing or ameliorating cancer, such as T-cell lymphomas, various microbial infections, such as HIV and TB, and also autoimmune disease. The invention is especially concerned with the use of CAR-engineered mucosal-associated invariant T (MAIT) cells, and to novel methods for stimulating, isolating, and expanding highly purified MAIT cells, which can then be engineered into such CAR-MAIT cells. The invention is also concerned with methods for expansion of MAIT cells in vitro.

Abstract: The present invention relates to chimeric antigen receptor (CAR)-T cells, and particularly, although not exclusively, to anti-CD4 CARs, and to their use in immunotherapy, and for treating, preventing or ameliorating cancer, such as T-cell lymphomas, various microbial infections, such as HIV and TB, and also autoimmune disease. The invention is especially concerned with the use of CAR-engineered mucosal-associated invariant T (MAIT) cells, and to novel methods for stimulating, isolating and expanding highly purified MAIT cells, which can then be engineered into such CAR-MAIT cells. The invention extends to genetic constructs per se, and to their use in generating the CAR-MAIT cells, and to transduced CAR-MAIT cells per se. The invention also extends to various medical uses of the constructs and transduced CAR-MAIT cells, and to pharmaceutical compositions comprising these constructs and CAR-MAIT cells.

Abstract: A method is disclosed for manufacturing a high dielectric constant metal gate of NMOS and PMOS, comprising: step 1, forming an interface layer; step 2, forming a high dielectric constant layer; step 3, performing decoupled plasma nitridation; step 4, performing plasma nitridation annealing with a temperature set below a preset first temperature to reduce the number of oxygen vacancies in the high dielectric constant layer; step 5, forming a P-type work function metal layer; step 6, removing the P-type work function metal layer from the region of the gate structure of the NMOS; step 7, forming an N-type work function metal layer, wherein metal atoms of the N-type work function metal layer of a first NMOS diffuses laterally from an interface to the P-type work function metal layer of adjacent first PMOS and are fixed at the oxygen vacancies by forming a dipole; and step 8, forming the metal gate.

Abstract: The present invention relates to a novel FXR agonist having a pyrazine structure, a preparation method therefor and the use thereof, and in particular relates to a compound as represented by the following general formula (I), or a hydrate, a solvate or a pharmaceutically acceptable salt thereof or a resolved single isomer thereof, which has the effect of treating non-alcoholic fatty liver disease.

Abstract: Disclosed is a hierarchical management method and system for a terminal device. The terminal device comprises at least one control system, and at least one peripheral apparatus, which is connected to the control system. In the method, when a terminal device receives a wake-up signal during dormancy, a control system corresponding to the wake-up signal is woken up, and the control system in a wake-up state grades an operation mode of the control system according to a data load; and according to the operation mode, a peripheral apparatus that needs to perform data processing is woken up.

Abstract: A seesaw-type feeding device for collecting solid materials suspended in a flow field includes a suspension assembly, a material collection assembly, a joint hinge, two anti-collision blocks and an escapement shaking assembly, wherein the latter three of which are located between the suspension assembly and the material collection assembly. The suspension assembly includes a V-shaped floating body and at least three fixed bottom anchors. The material collection assembly includes a collection pocket net, a material container, a delivery part, and an annular water discharging screen mesh. The escapement shaking assembly is located behind the V-shaped floating body and faces the material collection assembly. The material collection assembly is able to shake relatively to the fluid in the flow field, and the escapement shaking assembly drives the material collection assembly to shake.

Abstract: The application discloses a method of applying the stress memorization technique in making the semiconductor device which includes: step 1: forming a front gate structure on a silicon wafer having front and back surfaces; step 2: forming sidewalls including a first silicon nitride sidewall, a first silicon nitride layer corresponding to the first silicon nitride sidewall covering a first polysilicon layer on the wafer's back surface; step 3: growing a second silicon nitride layer on the wafer's front surface; step 4: etching the silicon nitride after stress transfer is completed, including: step 41: performing front single-wafer wet etching; step 42: performing batch wet etching to completely remove the second silicon nitride layer and reduces the thickness of the first silicon nitride layer on the back surface; step 5: completing the subsequent process. The application can improve the wafer flatness for improved photolithography for back-end-of-line processes and thereby increasing product yield.

Abstract: Provided are a display module, a display device and a driving method of the display module. The display module includes: a display panel, where the display panel includes a display area and a non-display area, a substrate, and a plurality of sub-pixels and a power line disposed on the substrate; a flexible circuit board, where the flexible circuit board is bound to the substrate in the non-display area and includes a power bus electrically connected to the power line; a driver chip including at least one detection pin and at least one control pin; and a voltage detection circuit including a first detection terminal, a second detection terminal, an output terminal and a control terminal.

Abstract: The application discloses a method of applying the stress memorization technique in making the semiconductor device which includes: step 1: forming a front gate structure on a silicon wafer having front and back surfaces; step 2: forming sidewalls including a first silicon nitride sidewall, a first silicon nitride layer corresponding to the first silicon nitride sidewall covering a first polysilicon layer on the wafer's back surface; step 3: growing a second silicon nitride layer on the wafer's front surface; step 4: etching the silicon nitride after stress transfer is completed, including: step 41: performing front single-wafer wet etching; step 42: performing batch wet etching to completely remove the second silicon nitride layer and reduces the thickness of the first silicon nitride layer on the back surface; step 5: completing the subsequent process. The application can improve the wafer flatness for improved photolithography for back-end-of-line processes and thereby increasing product yield.

Abstract: Provided is an apparatus for enriching and screening a target object such as a cell, bacteria or biomolecule from a sample, comprising a plurality of multi-channel mesh bodies arranged in parallel, each multi-channel mesh body comprising a mesh body formed by intersecting a plurality of threads, a plurality of screen pores formed by intersecting the plurality of threads, and a capturing layer formed on the mesh body. The capturing layer comprises a capturing material specifically binding with the target object, and the screen pores of two adjacent layers of multi-channel mesh bodies are partially staggered. The present invention improves the capture rate of the target object in the case of ensuring high flux.

Abstract: Provided are a display module, a display device and a driving method of the display module. The display module includes: a display panel, where the display panel includes a display area and a non-display area, a substrate, and a plurality of sub-pixels and a power line disposed on the substrate; a flexible circuit board, where the flexible circuit board is bound to the substrate in the non-display area and includes a power bus electrically connected to the power line; a driver chip including at least one detection pin and at least one control pin; and a voltage detection circuit including a first detection terminal, a second detection terminal, an output terminal and a control terminal.

Abstract: The present disclosure provides a method for separating soluble organic matter in petroleum coke, including: drying the petroleum coke to obtain pretreated petroleum coke; extracting the pretreated petroleum coke sequentially with petroleum ether, carbon disulfide, ethanol, acetone-carbon disulfide mixture and tetrahydrofuran to obtain an extract and the treated petroleum coke, wherein the extract includes soluble organic matter. The method provided by the present disclosure employs extractants with different polarities, i.e., petroleum ether, carbon disulfide, ethanol, acetone-carbon disulfide mixture and tetrahydrofuran, to extract petroleum coke sequentially, so as to detect the composition of the soluble organic matter in petroleum coke at the molecular level, realizing the separation of soluble organic matter in petroleum coke at the macro molecular level, as well as the determination of molecular structure of soluble organic matter in petroleum coke by modern detection processes.

Abstract: The present invention relates to the uses of sesquiterpene lactone compounds and their derivatives in preparing drugs. It belongs to the field of drug technology, specifically relates to the uses of the compounds of Formula (I) in preparing the drugs, especially the uses in preparing the drugs to treat rheumatoid arthritis and treat cancers through inhibiting cancer stem cells.

Abstract: The present disclosure provides a method for separating soluble organic matter in petroleum coke, including: drying the petroleum coke to obtain pretreated petroleum coke; extracting the pretreated petroleum coke sequentially with petroleum ether, carbon disulfide, ethanol, acetone-carbon disulfide mixture and tetrahydrofuran to obtain an extract and the treated petroleum coke, wherein the extract includes soluble organic matter. The method provided by the present disclosure employs extractants with different polarities, i.e., petroleum ether, carbon disulfide, ethanol, acetone-carbon disulfide mixture and tetrahydrofuran, to extract petroleum coke sequentially, so as to detect the composition of the soluble organic matter in petroleum coke at the molecular level, realizing the separation of soluble organic matter in petroleum coke at the macro molecular level, as well as the determination of molecular structure of soluble organic matter in petroleum coke by modern detection processes.

Abstract: Provided are Universal Serial Bus (USB) wireless network card configuration methods, a host, a USB wireless network card and a communication system. A host enters a configuration mode after connecting with a USB wireless network card, acquires, in the configuration mode, configured interface combination information including each function interface configured by a user, and then sends the configured interface combination information to the USB wireless network card.

Abstract: Provided are a USB device, a communication system and a method thereof for work mode switching, where the method for work mode switching of the USB device includes: a USB device is inserted into a host, wherein the USB device is configured with single disk device information and at least one type of work mode information; the single disk device information is sent to the host by the USB device, wherein the single disk device information includes installation information as per which the host installs a function management module; and a work mode is selected by the USB device according to a configuration instruction issued by the function management module of the host and configured as a current valid work mode.