Abstract: Disclosed in the present invention are an aromatic acetylene derivative, a preparation method therefor, a pharmaceutical composition containing the derivative, and the use of the aromatic acetylene derivative or the pharmaceutical composition thereof in medicines. Specifically, disclosed in the present invention are an aromatic acetylene derivative as represented by general formula (A-I), a preparation method therefor and a pharmaceutically acceptable salt thereof, and the use thereof as a therapeutic agent, particularly an LPXC inhibitor, wherein the definition of each substituent in the general formula (A-I) is the same as that in the description.

Abstract: An antigen-binding molecule specifically binding to HGFR and EGFR, and the pharmaceutical use thereof. The antigen-binding molecule can be used for treating tumor-related diseases.

Abstract: Provided are a determination method and apparatus of a main shaft bearing state, an electronic device, and a storage medium. The method includes the following steps: Bearing swing data of a target main shaft bearing at multiple moments within a preset time period are acquired; at least one current data period and current-period bearing swing data in each current data period are determined according to the multiple pieces of bearing swing data; a first abrupt change value and a second abrupt change value are determined according to the current-period bearing swing data in each current data period; and a main shaft bearing state of the target main shaft bearing is determined according to the first abrupt change value and the second abrupt change value.

Abstract: Disclosed are a live broadcast stream pushing method and apparatus, and an electronic device. One specific embodiment of the method comprises: receiving viewing permission setting information, wherein the viewing permission setting information is used for representing viewing permission of viewing a live broadcast stream of a multimedia conference; on the basis of the live broadcast starting state of the multimedia conference and the viewing permission setting information, determining whether to push the live broadcast stream of the multimedia conference to a requester who requests the live broadcast stream; and in response to determining to push the live broadcast stream of the multimedia conference to the requester, pushing the live broadcast stream of the multimedia conference to the requester. According to the embodiment, the flexibility of pushing a live broadcast stream of a multimedia conference is improved.

Abstract: Embodiments of the present application disclose a traffic data self-recovery processing method, including: monitoring an operation result of traffic data synchronization operation of a target system; repeatedly performing the traffic data synchronization operation of the target system until the traffic data synchronization is successful or cumulative number of traffic data synchronization failures exceed a failure frequency threshold, if the monitored operation result is that the traffic data synchronization is failed; clearing the cumulative number if the monitored operation result is that the traffic data synchronization is successful; stopping the traffic data synchronization operation of the target system and sending out a message indicative of the traffic data synchronization failure if the cumulative number of traffic data synchronization failures exceeds the failure frequency threshold, wherein the failure frequency threshold is determined by current network signal intensity of the target system and is

Abstract: Disclosed are a live broadcast stream pushing method and apparatus, and an electronic device. One specific embodiment of the method comprises: receiving viewing permission setting information, wherein the viewing permission setting information is used for representing viewing permission of viewing a live broadcast stream of a multimedia conference; on the basis of the live broadcast starting state of the multimedia conference and the viewing permission setting information, determining whether to push the live broadcast stream of the multimedia conference to a requester who requests the live broadcast stream; and in response to determining to push the live broadcast stream of the multimedia conference to the requester, pushing the live broadcast stream of the multimedia conference to the requester. According to the embodiment, the flexibility of pushing a live broadcast stream of a multimedia conference is improved.

Abstract: A multi-frequency uniformization carrier wave slope random distribution pulse width modulation method, includes: (1) selecting a required random carrier wave sequence and a modulating wave, and after the two are compared, generating a switch device drive signal for pulse width modulation; (2) determining a multiple n of an equivalent carrier frequency f of the random carrier wave sequence, and selecting a main circuit topology; and (3) inputting the switch device drive signal generated in (1) into the main circuit topology of (2) to perform multi-frequency uniformization carrier wave slope random distribution pulse width modulation. The disclosure can improve a frequency domain distribution bandwidth of a harmonic wave without changing the mean and variance of a random carrier wave sequence, and realizes uniform distribution of carrier waves and multiple harmonic peaks near a doubled frequency of the carrier waves in a wider frequency domain.

Abstract: Embodiments of the present application disclose a traffic data self-recovery processing method, including: monitoring an operation result of traffic data synchronization operation of a target system; repeatedly performing the traffic data synchronization operation of the target system until the traffic data synchronization is successful or cumulative number of traffic data synchronization failures exceed a failure frequency threshold, if the monitored operation result is that the traffic data synchronization is failed; clearing the cumulative number if the monitored operation result is that the traffic data synchronization is successful; stopping the traffic data synchronization operation of the target system and sending out a message indicative of the traffic data synchronization failure if the cumulative number of traffic data synchronization failures exceeds the failure frequency threshold, wherein the failure frequency threshold is determined by current network signal intensity of the target system and is

Abstract: A multi-frequency uniformization carrier wave slope random distribution pulse width modulation method, includes: (1) selecting a required random carrier wave sequence and a modulating wave, and after the two are compared, generating a switch device drive signal for pulse width modulation; (2) determining a multiple n of an equivalent carrier frequency f of the random carrier wave sequence, and selecting a main circuit topology; and (3) inputting the switch device drive signal generated in (1) into the main circuit topology of (2) to perform multi-frequency uniformization carrier wave slope random distribution pulse width modulation. The disclosure can improve a frequency domain distribution bandwidth of a harmonic wave without changing the mean and variance of a random carrier wave sequence, and realizes uniform distribution of carrier waves and multiple harmonic peaks near a doubled frequency of the carrier waves in a wider frequency domain.

Abstract: The invention relates to a microarray design of hybrid upconversion nanoparticles on a nanoporous anodized alumina membrane heterogeneous assay for simultaneous detection of multiple oligonucleotides, for example, oligonucleotides from different types of viruses.

Abstract: The invention relates to a microarray design of hybrid upconversion nanoparticles on a nanoporous anodized alumina membrane heterogeneous assay for simultaneous detection of multiple oligonucleotides, for example, oligonucleotides from different types of viruses.