Abstract: Provided are compounds of Formula (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: A preparation method for high-strength and low-modulus ?-type Si-containing titanium alloy involves: preparing an alloy component with, in atomic percentage, 60-70% of Ti, 10-20% of Nb, 5-15% of Zr, 1-10% of Ta and 1-5% of Si and using sponge titanium, sponge zirconium, a tantalum-niobium intermediate alloy and silicon as raw materials, and then uniformly smelting the alloy components to obtain a solidified ingot; then, subjecting the resulting ingot to plastic deformation with a deformation temperature of 800-900° C. and a deformation rate of 60-80%, and water-quenching same to room temperature; and finally, heating the resulting test sample to a recrystallization temperature, maintaining the temperature for 1-4 h, and carrying out an annealing treatment and air-cooling same to room temperature to obtain the high-strength and low-modulus ?-type Si-containing titanium alloy. The resulting titanium alloy is more suitable for use as a medical implant material.

Abstract: A partial pressure tool for real-time measurement and adjustment of pressure and viscosity and a measurement method thereof. The partial pressure tool includes an outer cylinder and adjustable annular throttling grooves, and the adjustable annular throttling grooves are split-type grooves vertically and successively installed on an inner wall of the outer cylinder at equal intervals. Four single throttling grooves are adjacent to each other and arranged concentrically on a circumferential surface. A viscometer is installed on a surface of an arc-shaped inner plate in a tail-end adjustable annular throttling groove. The viscometer is connected to an induction board through a transmission line. The arc-shaped inner plate in the tail-end adjustable annular throttling groove is provided with a pressure sensor and a torque sensor, and the pressure sensor and the torque sensor both are connected to the induction board. The induction board is connected to a DSP control module.

Abstract: A high-strength dual-scale structure titanium alloy, a preparation method therefor, and an application thereof, belonging to the technical field of alloy processing. The composition system of the titanium alloy is Ti—Nb—Cu—Co—Al, the atomic percentage of the various elements being 58˜70% Ti, 9˜16% Nb, 4˜9% Cu, 4˜9% Co, and 2˜8% Al. The microstructure comprises a dual-scale coexistence of micro-crystal isometric bcc ?-Ti and ultra-fine crystal isometric bcc ?-Ti, and a dual-scale coexistence of micro-crystal strip fcc CoTi2 and ultra-fine crystal isometric fcc CoTi2, or an ultra-fine crystal strip fcc CoTi2 twin crystal is distributed along a boundary of a dual-scale substrate, the dual-scale substrate being a nano needle-shaped martensite a? phase dispersed within micro-crystal bcc ?-Ti. The mechanical properties of the titanium alloy are significantly improved, and the titanium alloy may be used in fields such as aerospace and aviation, weaponry and sports equipment.

Abstract: A partial pressure tool for real-time measurement and adjustment of pressure and viscosity and a measurement method thereof. The partial pressure tool includes an outer cylinder and adjustable annular throttling grooves, and the adjustable annular throttling grooves are split-type grooves vertically and successively installed on an inner wall of the outer cylinder at equal intervals. Four single throttling grooves are adjacent to each other and arranged concentrically on a circumferential surface. A viscometer is installed on a surface of an arc-shaped inner plate in a tail-end adjustable annular throttling groove. The viscometer is connected to an induction board through a transmission line. The arc-shaped inner plate in the tail-end adjustable annular throttling groove is provided with a pressure sensor and a torque sensor, and the pressure sensor and the torque sensor both are connected to the induction board. The induction board is connected to a DSP control module.

Abstract: The present invention belongs to the field of titanium alloy materials, and disclosed are a high-strength and low-modulus ?-type Si-containing titanium alloy, a preparation method therefor and the use thereof. The preparation method involves: preparing an alloy component with, in atomic percentage, 60-70% of Ti, 10-20% of Nb, 5-15% of Zr, 1-10% of Ta and 1-5% of Si and using sponge titanium, sponge zirconium, a tantalum-niobium intermediate alloy and silicon as raw materials, and then uniformly smelting the alloy component to obtain a solidified ingot; then, subjecting the resulting ingot to high temperature plastic deformation with a deformation temperature of 800-900° C.

Abstract: A vegetable washing method capable of separating and splitting impurities and a machine therefor. The method comprises putting fruit and vegetable into a washing basket, then driving the wash basket to rotate by an electric motor so as to force water flow to circulate repeatedly, as a result separating the impurities and the vegetable. The method has the following three technical features of A, B and C, or at least has one of them. A. using a method for preventing the impurities thrown outside the washing basket together with the water from circularly falling into the basket again together with the water to gradually purify the vegetable in the basket; B. using a vortex center draining method to discharge the sewage and impurities; C. using a method for making the vegetable in the washing basket periodically centripetal and centrifugal motion to flip and turn the placement angle of the vegetable in the basket.

Abstract: Methods of pre-methylation of foreign DNA to improve genetic transformation in cyanobacterium. Two Type II methyltransferase-encoding genes, i.e., M (sll0729) and C (slr0214), were cloned from the chromosome of Synechocystis sp. PCC 6803 (hereafter Synechocystis 6803) and expressed in E. coli that harbors the integrative plasmid pBS-SPtK or pJU105. After pre-methylation in E. coli, the integrative plasmids were extracted and used for transformation of Synechocystis 6803. The results showed that expression of slr0214 in the integrative-plasmid-harboring E. coli cells before DNA preparation resulted in orders of magnitude higher efficiency in the following integrative transformation of Synechocystis 6803.

Abstract: Construction and expression of synthetic pathways to produce (S) or (R)-3-hydroxybutyrate (3HB) as enantiomerically-pure products by genetically engineering cyanobacterium Synechocystis sp. PCC 6803. Under optimized growth conditions, the pathway employing phaA and phaB from R. eutropha was the most effective, producing up to 533.4±5.5 mg/l (R)-3HB after 21 days photosynthetic cultivation. For the first time, the feasibility and high efficiency of producing 3HB using solar energy and CO2 as sole energy and carbon sources by engineered cyanobacteria is demonstrated.

Abstract: Construction and expression of synthetic pathways to produce (S) or (R)-3-hydroxybutyrate (3HB) as enantiomerically-pure products by genetically engineering cyanobacterium Synechocystis sp. PCC 6803. Under optimized growth conditions, the pathway employing phaA and phaB from R. eutropha was the most effective, producing up to 533.4±5.5 mg/l (R)-3HB after 21 days photosynthetic cultivation. For the first time, the feasibility and high efficiency of producing 3HB using solar energy and CO2 as sole energy and carbon sources by engineered cyanobacteria is demonstrated.

Abstract: A high-strength dual-scale structure titanium alloy, a preparation method therefor, and an application thereof, belonging to the technical field of alloy processing. The composition system of the titanium alloy is Ti—Nb—Cu—Co—Al, the atomic percentage of the various elements being 58˜70% Ti, 9˜16% Nb, 4˜9% Cu, 4˜9% Co, and 2˜8% Al. The microstructure comprises a dual-scale coexistence of micro-crystal isometric bcc ?-Ti and ultra-fine crystal isometric bcc ?-Ti, and a dual-scale coexistence of micro-crystal strip fcc CoTi2 and ultra-fine crystal isometric fcc CoTi2, or an ultra-fine crystal strip fcc CoTi2 twin crystal is distributed along a boundary of a dual-scale substrate, the dual-scale substrate being a nano needle-shaped martensite ?? phase dispersed within micro-crystal bcc ?-Ti. The mechanical properties of the titanium alloy are significantly improved, and the titanium alloy may be used in fields such as aerospace and aviation, weaponry and sports equipment.

Abstract: Construction and expression of synthetic pathways to produce (5) or (R)-3-hydroxybutyrate (3HB) as enantiomerically-pure products by genetically engineering cyanobacterium Synechocystis sp. PCC 6803. Under optimized growth conditions, the pathway employing phaA and phaB from R. eutropha was the most effective, producing up to 533.4±5.5 mg/l (R)-3HB after 21 days photosynthetic cultivation. For the first time, the feasibility and high efficiency of producing 3HB using solar energy and CO2 as sole energy and carbon sources by engineered cyanobacteria is demonstrated.

Abstract: A vegetable washing method capable of separating and splitting impurities and a machine therefor. The method comprises putting fruit and vegetable into a washing basket, then driving the wash basket to rotate by an electric motor so as to force water flow to circulate repeatedly, as a result separating the impurities and the vegetable. The method has the following three technical features of A, B and C, or at least has one of them. A. using a method for preventing the impurities thrown outside the washing basket together with the water from circularly falling into the basket again together with the water to gradually purify the vegetable in the basket; B. using a vortex center draining method to discharge the sewage and impurities; C. using a method for making the vegetable in the washing basket periodically centripetal and centrifugal motion to flip and turn the placement angle of the vegetable in the basket.

Abstract: Methods of pre-methylation of foreign DNA to improve genetic transformation in cyanobacterium. Two Type II methyltransferase-encoding genes, i.e., M (sll0729) and C (slr0214), were cloned from the chromosome of Synechocystis sp. PCC 6803 (hereafter Synechocystis 6803) and expressed in E. coli that harbors the integrative plasmid pBS-SPtK or pJU105. After pre-methylation in E. coli, the integrative plasmids were extracted and used for transformation of Synechocystis 6803. The results showed that expression of slr0214 in the integrative-plasmid-harboring E. coli cells before DNA preparation resulted in orders of magnitude higher efficiency in the following integrative transformation of Synechocystis 6803.

Abstract: The present invention relates to an optical fluorescence dual sensor comprising a probe for sensing pH, a probe for sensing oxygen, an intra-reference probe and a matrix. The present invention also relates to methods of preparing an optical fluorescence dual sensor and methods of using them.

Abstract: The present invention provides methods and systems for organizing complex and disparate data. More specifically, the present invention provides methods and systems for organizing complex and disparate data into coherent data sets. Coherent data sets resulting from the methods and systems of the present invention serve as models for biological systems. Methods and systems for integrating data and creating coherent data sets are useful for numerous biological applications, such as, for example, determining gene function, identifying and validating drug and pesticide targets, identifying and validating drug and pesticide candidate compounds, profiling drug and pesticide compounds, producing a compilation of health or wellness profiles, determining compound site(s) of action, identifying unknown samples, and numerous other applications in the agricultural, pharmaceutical, forensic, and biotechnology industries.

Abstract: The present invention provides methods and systems for organizing complex and disparate data. More specifically, the present invention provides methods and systems for organizing complex and disparate data into coherent data sets. Coherent data sets resulting from the methods and systems of the present invention serve as models for biological systems. Methods and systems for integrating data and creating coherent data sets are useful for numerous biological applications, such as, for example, determining gene function, identifying and validating drug and pesticide targets, identifying and validating drug and pesticide candidate compounds, profiling drug and pesticide compounds, producing a compilation of health or wellness profiles, determining compound site(s) of action, identifying unknown samples, and numerous other applications in the agricultural, pharmaceutical, forensic, and biotechnology industries.

Abstract: The present invention provides methods and systems for organizing complex and disparate data. More specifically, the present invention provides methods and systems for organizing complex and disparate data into coherent data sets. Coherent data sets resulting from the methods and systems of the present invention serve as models for biological systems. Methods and systems for integrating data and creating coherent data sets are useful for numerous biological applications, such as, for example, determining gene function, identifying and validating drug and pesticide targets, identifying and validating drug and pesticide candidate compounds, profiling drug and pesticide compounds, producing a compilation of health or wellness profiles, determining compound site(s) of action, identifying unknown samples, and numerous other applications in the agricultural, pharmaceutical, forensic, and biotechnology industries.

Abstract: The present invention provides methods and systems for organizing complex and disparate data. More specifically, the present invention provides methods and systems for organizing complex and disparate data into coherent data sets. Coherent data sets resulting from the methods and systems of the present invention serve as models for biological systems. Methods and systems for integrating data and creating coherent data sets are useful for numerous biological applications, such as, for example, determining gene function, identifying and validating drug and pesticide targets, identifying and validating drug and pesticide candidate compounds, profiling drug and pesticide compounds, producing a compilation of health or wellness profiles, determining compound site(s) of action, identifying unknown samples, and numerous other applications in the agricultural, pharmaceutical, forensic, and biotechnology industries.

Abstract: The present invention provides methods and systems for organizing complex and disparate data. More specifically, the present invention provides methods and systems for organizing complex and disparate data into coherent data sets. Coherent data sets resulting from the methods and systems of the present invention serve as models for biological systems. Methods and systems for integrating data and creating coherent data sets are useful for numerous biological applications, such as, for example, determining gene function, identifying and validating drug and pesticide targets, identifying and validating drug and pesticide candidate compounds, profiling drug and pesticide compounds, producing a compilation of health or wellness profiles, determining compound site(s) of action, identifying unknown samples, and numerous other applications in the agricultural, pharmaceutical, forensic, and biotechnology industries.