Patents by Inventor Weixian Xi
Weixian Xi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230416435Abstract: A co-polymer includes a plurality of a first monomer including a terminal functional group that is to attach to at least two different primers; a plurality of a second monomer including a second functional group that is different from the terminal functional group, and that is selected from the group consisting of a phenyl group, methoxy propyl, glycosyl, vinyl pyrrolidone, and an imidazole group; and a plurality of a third monomer that is different from the first and second monomers. This co-polymer may be used in a flow cell, and may enhance the clustering efficiency and kinetics.Type: ApplicationFiled: June 6, 2023Publication date: December 28, 2023Inventors: Gianluca Andrea Artioli, Timothy J.N. Beech, Mathieu Lessard-Viger, Rebecca Turk-MacLeod, Brian D. Mather, Weixian Xi, Xavier von Hatten
-
Publication number: 20230102550Abstract: Provided herein are various examples of a method of coupling oligonucleotides to a polymer. The method may include selectively irradiating first inactive moieties in a one or more first region of a polymer with light, while not irradiating second inactive moieties in a one or more second region of the polymer, to generate first active moieties in the one or more first region of the polymer. The method may also include coupling the first active moieties to first oligonucleotides. The method may further include irradiating the second inactive moieties in the one or more second region of the polymer with light to generate second active moieties in the one or more second region of the polymer. The method may also include coupling the second active moieties to second oligonucleotides.Type: ApplicationFiled: July 29, 2022Publication date: March 30, 2023Applicants: ILLUMINA, INC., ILLUMINA CAMBRIDGE LIMITEDInventors: Weixian XI, Tanmay GHONGE, Sahngki HONG, Alexandra SZEMJONOV
-
Publication number: 20230081945Abstract: A polymeric medical device/implant coating is disclosed for the delivery of drugs or therapeutic compounds such as antibiotics over an extended period of time and at levels or concentrations that exceed the MIC. In one embodiment, an antibiotic such as vancomycin is encapsulated in a photo-crosslinked poly(lactide-co-glycolide) (PLGA)-dimethacrylate coating. The drug release profile of this coating was studied and the initial burst was reduced by photo-crosslinking. Due to photo-crosslinking, an additional diffusional resistance was created, which prevented easy diffusion of the drug into the release medium. Moreover, the time required for this coating process is very quick (e.g., around 5 minutes) and makes it compatible for this coating to be applied in the operating room.Type: ApplicationFiled: February 24, 2021Publication date: March 16, 2023Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Nicholas Bernthal, Weixian Xi, Tatiana Segura
-
Publication number: 20230042267Abstract: An example of a kit includes a flow cell, a primer fluid, and a cleaving fluid. The flow cell includes at least one surface functionalized with a polymeric hydrogel including azide functional groups or amine functional groups. The primer fluid includes a plurality of alkyne-containing primers, each alkyne-containing primer having an amino cleavable group attaching a primer sequence of the alkyne-containing primer to an alkyne-containing moiety of the alkyne-containing primer. The cleaving fluid includes a substance that is reactive with the amino cleavable group.Type: ApplicationFiled: June 30, 2022Publication date: February 9, 2023Inventors: Jonathan Mark Boutell, Wayne N. George, Xiaoyu Ma, Xiaolin Wu, Weixian Xi
-
Publication number: 20230016633Abstract: Embodiments of the present application relate to substrate comprising a surface-bound azido functionalized organosilane wherein the substrate is free or substantially free of a hydrogel or a hydrophilic polymer. Methods of preparing such substrate surface for sequencing applications are also disclosed.Type: ApplicationFiled: June 13, 2022Publication date: January 19, 2023Inventors: Xiaoyu Ma, Weixian Xi, Jeffrey S. Fisher, Fei Shen, Wayne N. George, Brian D. Mather
-
Publication number: 20220289876Abstract: In some examples, a method of coupling oligonucleotides to a polymer is provided. Inactive moieties in a first region of a polymer may be selectively irradiated with light, while inactive moieties in a second region of the polymer are not irradiated, to generate first active moieties in the first region of the polymer. The first active moieties may be coupled to first oligonucleotides. The inactive moieties in the second region of the polymer may be irradiated with light to generate second active moieties in the second region of the polymer. The second active moieties may be coupled to second oligonucleotides.Type: ApplicationFiled: March 4, 2022Publication date: September 15, 2022Applicant: ILLUMINA, INC.Inventors: Brian Mather, Weixian Xi
-
Publication number: 20190388583Abstract: A copolymer poly(ethylene glycol)-polyallyl mercaptan (PEG-PAM) material is used as a drug-containing coating for medical implants. In one embodiment, a mixture of multi-arm poly(ethylene glycol) (PEG), polyallyl mercaptan (PAM), a photoinitiator, organic solvent, and one or more drugs, medicaments, or pharmaceutical compounds is applied to a surface of the implant and is exposed to a polymerizing light source to form a PEG-PAM material coating that is formed in situ on the implant. The PEG-PAM coating may be used by surgeons to incorporate antibacterial drugs or the like into coatings that are applied in the operating room setting to medical devices such as orthopedic implants. The type of drug and dosing can be customized during the coating operation and tailored to the patient's needs. PEG-PAM may also be applied as a coating on or within tissue or an injectable gel.Type: ApplicationFiled: January 30, 2018Publication date: December 26, 2019Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventors: Tatiana Segura, Nicolas Bernthal, Weixian Xi
-
Patent number: 10508116Abstract: Disclosed herein are Click Nucleic Acid Polymers (CNA-polymers) that comprise repeating dimer, trimer and tetramer units. The disclosed polymers can be used for antisense applications, for example, in treatment of “trinucleotide repeat disorders, i.e., Huntington's Disease and the like.Type: GrantFiled: October 6, 2017Date of Patent: December 17, 2019Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODYInventors: Christopher N. Bowman, Weixian Xi, Sankha Pattanayak
-
Patent number: 10017510Abstract: Click thiol-X monomers and polymers containing such monomers are disclosed. The clickable sequence controllable monomers include an optionally protected thiol moiety; an optionally protected Michael acceptor moiety; a primary functional side chain and one ore more secondary functional side chains. A clickable sequence controllable monomer, can have the structure: wherein independently Y and Z are atoms having a valence electrons of 3 or more; n is a integer from 0-10; m is a integer from 0-10; x is a integer from 0-10; PFS is a functional group SFSi; SFS2; and SFS3 are independently a combination of hydrogen, hydroxyl, aromatic, amine, carboxyl, and carbonyls, optionally substituted to form hydrophilic, hydrophobic, amphiphilic, or charged (positive or negative or both) side chains; T is an optionally protected thiol; and TCA is an optionally protected thiol-click acceptor. Methods of using such polymers are also disclosed.Type: GrantFiled: February 6, 2015Date of Patent: July 10, 2018Assignee: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATEInventors: Christopher N. Bowman, Christopher J. Kloxin, Weixian Xi, Tao Gong, Sankha Pattanayak
-
Publication number: 20180100036Abstract: Disclosed herein are Click Nucleic Acid Polymers (CNA-polymers) that comprise repeating dimer, trimer and tetramer units. The disclosed polymers can be used for antisense applications, for example, in treatment of “trinucleotide repeat disorders, i.e., Huntington's Disease and the like.Type: ApplicationFiled: October 6, 2017Publication date: April 12, 2018Inventors: Christopher N. Bowman, Weixian Xi, Sankha Pattanayak
-
Patent number: 9879012Abstract: Click nucleic acid monomers and polymers containing such monomers are disclosed. The click nucleic acid monomers include an optionally protected thiol moiety, an optionally protected thiol-click acceptor moiety, and an optionally protected nucleobase (NB), which in some examples is an A, G, T, U, or C nucleobase. In some examples, the click nucleic acid monomer includes a N-vinyl thiol acetamide (VTA) backbone. In other examples the click nucleic acid monomer includes a N-vinyl thiol ethylamine (VTE) backbone. Methods of using such polymers, for example in place of naturally occurring nucleic acid polymer applications, such as DNA or RNA, and synthetic nucleic acid polymer applications, such as PNA or morpholino nucleic acids, are also disclosed.Type: GrantFiled: March 12, 2013Date of Patent: January 30, 2018Assignee: REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATEInventors: Christopher N. Bowman, Christopher J. Kloxin, Weixian Xi
-
Patent number: 9700492Abstract: The invention includes a composition comprising a vinyl sulfone monomer, a thiol monomer, and optionally an isocyanate monomer. The invention further includes a composition comprising a composition comprising the tetra(2-mercapto)silane (SiTSH) monomer and at least one selected from the group consisting of (a) a Michael acceptor, optionally an isocyanate monomer, and optionally at least one catalyst selected from the group consisting of a base, nucleophile, photolabile base, photolabile nucleophile, and mixtures thereof; (b) an ene monomer, and optionally a polymerization photoinitiator. In certain embodiments, once the composition is polymerized, the polymerized system is suitable for use as a dental composite system. In other embodiments, the polymerized system is stable to acidic and basic conditions. In yet other embodiments, the polymerized system forms microparticles. The invention further includes a method of generating a dental polymeric material.Type: GrantFiled: March 6, 2015Date of Patent: July 11, 2017Assignee: The Regents of the University of Colorado, a body corporateInventors: Christopher N. Bowman, Weixian Xi, Shunsuke Chatani, Tao Gong, Devatha P. Nair, Maciej Podgorski
-
Publication number: 20170015667Abstract: Click thiol-X monomers and polymers containing such monomers are disclosed. The clickable sequence controllable monomers include an optionally protected thiol moiety; an optionally protected Michael acceptor moiety; a primary functional side chain and one ore more secondary functional side chains. A clickable sequence controllable monomer, can have the structure: wherein independently Y and Z are atoms having a valence electrons of 3 or more; n is a integer from 0-10; m is a integer from 0-10; x is a integer from 0-10; PFS is a functional group SFSi; SFS2; and SFS3 are independently a combination of hydrogen, hydroxyl, aromatic, amine, carboxyl, and carbonyls, optionally substituted to form hydrophilic, hydrophobic, amphiphilic, or charged (positive or negative or both) side chains; T is an optionally protected thiol; and TCA is an optionally protected thiol-click acceptor. Methods of using such polymers are also disclosed.Type: ApplicationFiled: February 6, 2015Publication date: January 19, 2017Inventors: Christopher N. BOWMAN, Christopher J. KLOXIN, Weixian XI, Tao GONG, Sankha PATTANAYAK
-
Publication number: 20150250687Abstract: The invention includes a composition comprising a vinyl sulfone monomer, a thiol monomer, and optionally an isocyanate monomer. The invention further includes a composition comprising a composition comprising the tetra(2-mercapto)silane (SiTSH) monomer and at least one selected from the group consisting of (a) a Michael acceptor, optionally an isocyanate monomer, and optionally at least one catalyst selected from the group consisting of a base, nucleophile, photolabile base, photolabile nucleophile, and mixtures thereof; (b) an ene monomer, and optionally a polymerization photoinitiator. In certain embodiments, once the composition is polymerized, the polymerized system is suitable for use as a dental composite system. In other embodiments, the polymerized system is stable to acidic and basic conditions. In yet other embodiments, the polymerized system forms microparticles. The invention further includes a method of generating a dental polymeric material.Type: ApplicationFiled: March 6, 2015Publication date: September 10, 2015Inventors: CHRISTOPHER N. BOWMAN, WEIXIAN XI, SHUNSUKE CHATANI, TAO GONG, DEVATHA P. NAIR, MACIEJ PODGORSKI
-
Publication number: 20150057187Abstract: Click nucleic acid monomers and polymers containing such monomers are disclosed. The click nucleic acid monomers include an optionally protected thiol moiety, an optionally protected thiol-click acceptor moiety, and an optionally protected nucleobase (NB), which in some examples is an A, G, T, U, or C nucleobase. In some examples, the click nucleic acid monomer includes a N-vinyl thiol acetamide (VTA) backbone. In other examples the click nucleic acid monomer includes a N-vinyl thiol ethylamine (VTE) backbone. Methods of using such polymers, for example in place of naturally occurring nucleic acid polymer applications, such as DNA or RNA, and synthetic nucleic acid polymer applications, such as PNA or morpholino nucleic acids, are also disclosed.Type: ApplicationFiled: March 12, 2013Publication date: February 26, 2015Inventors: Christopher N. Bowman, Christopher J. Kloxin, Weixian Xi