Abstract: A geosteering method and apparatus, and a storage medium, where the method includes: acquiring first well trajectory information of a target well, and first geological information and second geological information of the target well; determining, by using a plane where a first well trajectory is located as a steering profile, a geological structure line of a first class geological layer corresponding to the first geological information on the steering profile, and determining, by using the geological structure line of the first class geological layer as a reference and based on the second geological information, a geological structure line of a second class geological layer corresponding to the second geological information on the steering profile, so as to obtain a geosteering model of the target well; and using the geosteering model to perform geosteering on actual drilling of the target well.

Abstract: Provided is a heterocycle substituted ketone derivative, the structure of which is as shown in formula (I). Further provided are a pharmaceutically acceptable salt of the derivative, a stereoisomer thereof, a pharmaceutical composition and the medicinal use thereof.

Abstract: The present invention provides a mutant IDH inhibitor in dimeric or multimeric form. Specifically, the present invention provides a compound of formula I, Da-Wa-L-Wb-db??(I) or a pharmaceutically acceptable salt thereof. The compound of the present invention has excellent inhibitory activity against mutant IDH1.

Abstract: The present application is applicable to the field of integrated circuit technology, and provides a data writing method, system, apparatus, device and medium for an integrated circuit chip. The data writing method is applied to a writer, the integrated circuit chip is electrically connected with the writer through a power-supply positive terminal and a power-supply negative terminal, and the data writing method includes: sending a data writing order to the integrated circuit chip, where the data writing order is configured to instruct the integrated circuit chip to enter a data writing mode after receiving the data writing order; and performing data writing to the integrated circuit chip by controlling an electrical parameter of an input voltage of the power-supply positive terminal or the power-supply negative terminal of the integrated circuit chip after the integrated circuit chip enters the data writing mode.

Abstract: The present invention provides a class of compounds inhibiting TDG activity. Specifically, the present invention provides a compound having a novel structure as shown in formula I. The small molecule inhibitor of the present invention has an excellent inhibitory effect on TDG.

Abstract: The present invention relates to a pyrimido five-membered heterocyclic compound and use thereof as a mutant IDH2 inhibitor. Specifically, disclosed in the present invention are a pyrimido five-membered heterocyclic compound capable of serving as a mutant IDH2 inhibitor, or a stereoisomer or a tautomer, or a pharmaceutically acceptable salt, a hydrate or a solvate thereof. The present invention also relates to a pharmaceutical composition comprising the compound, and use thereof in the preparation of a medicament for preventing and/or treating a disease mediated by mutant IDH2.

Abstract: Disclosed are a substituted phenylpropenylpyridine derivative, a preparation method therefor and the use thereof as a PD-1/PD-L1 inhibitor. In particular, disclosed are a compound of formula (I) or a pharmaceutically acceptable salt, stereoisomer, solvate, or prodrug thereof, a preparation method therefor and the use thereof. The definition of each group in the formula is detailed in the description and claims.

Abstract: The present application is applicable to the field of integrated circuit technology, and provides a data writing method, system, apparatus, device and medium for an integrated circuit chip. The data writing method is applied to a writer, the integrated circuit chip is electrically connected with the writer through a power-supply positive terminal and a power-supply negative terminal, and the data writing method includes: sending a data writing order to the integrated circuit chip, where the data writing order is configured to instruct the integrated circuit chip to enter a data writing mode after receiving the data writing order; and performing data writing to the integrated circuit chip by controlling an electrical parameter of an input voltage of the power-supply positive terminal or the power-supply negative terminal of the integrated circuit chip after the integrated circuit chip enters the data writing mode.