Abstract: The present invention provides a method for preparing an additive-free cell-wall-broken granule of a Chinese medicinal material. The cell-wall-broken granule is obtained by medicinal material concocting and grinding, first cell-wall-breaking and grinding, screening, second wall-breaking and grinding, mixing, pelleting, and granulating and sieving. The obtained granule has a moderate tightness, a relatively rapid dissolution and diffusion and a good uniformity, overcoming problems of a difficulty of dissolution and diffusion and a poor uniformity of the existing cell-wall-broken granules.

Abstract: The present invention provides a method for preparing an additive-free cell-wall-broken granule of a Chinese medicinal material. The cell-wall-broken granule is obtained by medicinal material concocting and grinding, first cell-wall-breaking and grinding, screening, second wall-breaking and grinding, mixing, pelleting, and granulating and sieving. The obtained granule has a moderate tightness, a relatively rapid dissolution and diffusion and a good uniformity, overcoming problems of a difficulty of dissolution and diffusion and a poor uniformity of the existing cell-wall-broken granules.

Abstract: Frames of a video frame sequence capturing one or more skin regions of a body are provided to a first neural network. The first neural network generates respective appearance representations based on the frames. An appearance representation generated based on a particular frame is indicative of a spatial distribution of a physiological signal across the particular frame. Simultaneously with providing the frames to the first neural network, the frames are also provided to a second neural network. The second neural network determines the physiological signal based on the frames. Determining the physiological signal by the second neural network includes applying the appearance representations, generated by the first neural network, to outputs of one or more layers of the second neural network to emphasize regions, in the frames, that exhibit relatively stronger presence of the physiological signal and deemphasize regions, in the frames, that exhibit relatively weaker presence of physiological signal.

Abstract: Compositions and methods for enriching glycocompounds are disclosed which can comprise a glycocompound bound to a boronic acid compound which can be conjugated to a dendrimer.

Abstract: Frames of a video frame sequence capturing one or more skin regions of a body are provided to a first neural network. The first neural network generates respective appearance representations based on the frames. An appearance representation generated based on a particular frame is indicative of a spatial distribution of a physiological signal across the particular frame. Simultaneously with providing the frames to the first neural network, the frames are also provided to a second neural network. The second neural network determines the physiological signal based on the frames. Determining the physiological signal by the second neural network includes applying the appearance representations, generated by the first neural network, to outputs of one or more layers of the second neural network to emphasize regions, in the frames, that exhibit relatively stronger presence of the physiological signal and deemphasize regions, in the frames, that exhibit relatively weaker presence of physiological signal.

Abstract: Rhein analogues that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such rings system by facilitate non-covalent binding of the compounds to the DNA complex, such as by intercalation. In some embodiment, the compounds contain a flat or planar ring system as described above and one or more substituents which are alkylating moieties, electrophilic groups or Michael acceptors or groups which contain one or more alkylating moieties, electrophilic groups and/or Michael acceptors. The compounds described herein can also contain one more functional groups to improve the solubility of the compounds.

Abstract: Compositions and methods for enriching glycocompounds are disclosed which can comprise a glycocompound bound to a boronic acid compound which can be conjugated to a dendrimer.

Abstract: Inhibitors of SecA, and methods of making and using thereof, are described herein. The compounds described herein can be used to treat or prevent microbial infections, such as bacterial infections.

Abstract: Inhibitors of SecA, and methods of making and using thereof, are described herein. The compounds described herein can be used to treat or prevent microbial infections, such as bacterial infections.

Abstract: Rhein analogues that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such rings system by facilitate non-covalent binding of the compounds to the DNA complex, such as by intercalation. In some embodiment, the compounds contain a flat or planar ring system as described above and one or more substituents which are alkylating moieties, electrophilic groups or Michael acceptors or groups which contain one or more alkylating moieties, electrophilic groups and/or Michael acceptors. The compounds described herein can also contain one more functional groups to improve the solubility of the compounds.

Abstract: Inhibitors of SecA, and methods of making and using thereof, are described herein. The compounds described herein can be used to treat or prevent microbial infections, such as bacterial infections.